PhD candidate in the @inflammasomelab investigating ✨inflammasomes✨💅 | @IMBatUQ | he/him
Brisbane, Queensland
Joined September 2022
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Ever wondered how NLRP12 can drive autoinflammation? 👀
In our latest work, we show that NLRP12 is an endogenous inhibitor of NLRP3 inflammasome formation, but disease-causing NLRP12 mutants lose this capacity 🤯
New exciting work from the @inflammasomelab just out! Congratulations to @JaredCoombs_ , @DrAlinaZ , @CarolineLHolley and others! NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome | Science Signaling science.org/doi/10.1126/scis…
Jared Coombs retweeted
Non-alcoholic fatty liver disease (NAFLD) affects ~30-40% of adults
NAFLD progresses through stages - the latest stage that's still reversible is NASH (nonalcoholic steatohepatitis)
There have been no drug therapies for NASH - until three recent trials
🧵
Jared Coombs retweeted
It is out! 🚨 Phosphorous-free bacterial lipids can switch between pro- and anti-inflammatory depending on context!🔬 #Immunology #LipidBiology @PelegrinPablo @inflammasomelab
A big thanks to the reviewers and editors. It was a laborious but smooth process🥳
Jared Coombs retweeted
easy breezy beautiful... covergirl 💅
Issue 13 is complete!
Explore our ToC here: journals.biologists.com/jcs/…
Our cover image shows a bead sprouting assay of HUVECs expressing a c-Src mutant (magenta). The cells exhibit irregular blood vessel formation with actin in green & DAPI in blue. From @TEssebier et al. journals.biologists.com/jcs/…
ALT Journal of Cell Science cover
Jared Coombs retweeted
Researchers have discovered how the 'on-switch' for the body's inflammation machinery can get stuck, paving way for potential treatments for rare genetic inflammatory diseases. 🔗 bit.ly/4ahPE67
Prof Kate Schroder (@inflammasomelab),@JaredCoombs_,Dr Alina Zamoshnikova
Jared Coombs retweeted
Nice to see the review written by @_KateLawlor , me and the X-less James Vince on the nuts, bolts and consequences of MLKL and GSDM lytic cell death out now in @ImmunityCP
Check it out with a free download at:
authors.elsevier.com/c/1il2a… – at Melbourne, Victoria
Jared Coombs retweeted
Studying mice and cells from patients with an autoinflammatory condition, a team finds the #inflammasomes NLRP3 and NLRP6—but not NLRP12—initiate formation of ASC specks and that NLRP12 may suppress NLRP3. @IMBatUQ @inflammasomelab @JaredCoombs_ scim.ag/5Dx
Huge congratulations to everyone who contributed to this work over the years, especially the brilliant @DrAlinaZ and @inflammasomelab 👏👏👏
@IMBatUQ
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Jared Coombs retweeted
Delighted to share a new methods paper from @CarolineLHolley and @inflammasomelab for Live Imaging of Pyroptosis in Primary Murine Macrophages!
link.springer.com/protocol/1…
Jared Coombs retweeted
Excited to share a method developed by @S_Emming @inflammasomelab and our friends at Quench Bio for Quantifying Cell Death Induced by the NLRC4 Inflammasome!
link.springer.com/protocol/1…
Jared Coombs retweeted
Research highlight: @jazzy_yup, @S_Emming & Prof Kate Schroder @inflammasomelab comment on work from Zhang et al. providing key insight into regulatory mechanisms governing NLRP1 activation and potential for structure-based anti-inflammatory drug design bit.ly/47ufFyl
Jared Coombs retweeted
We start the Inclusivi-Tea Time event series every first Monday of the month 10:30 on the rooftop @IMBatUQ A simple formula for IMB members from diverse career stages, paths, marginalised backgrounds, and identities build connections and empower each other. ☕ paid by @EMCRA_IMB
Jared Coombs retweeted
"In these times when we have a lot of problems to solve, we can't afford to waste talent."
Hear chemistry laureate Michael Levitt speak about the importance of diversity.
#NobelPrize
Jared Coombs retweeted
Congratulations to Prof Kate Schroder (@inflammasomelab), winner of the IMB Inflazome Translation Award 🏆 and Dr Harrison Madge, winner of the Ignite Innovation Award 📷 at this week's Research Engagement Dinner.
Jared Coombs retweeted
To our First Australians: I’m sorry. As a country, Australia should have done better for you today.
Jared Coombs retweeted
We are so grateful to be able to host A/Prof @FZMarques yesterday and today at @IMBatUQ! Not only did we hear about her incredible research on the gut #microbiota and #hypertension, we also discovered ways to champion diversity in science. Thank you once again for visiting 🙏
Jared Coombs retweeted
During the twentieth century, women’s education levels continuously increased, and in most high-income countries they are now substantially higher than for men. Claudia Goldin – awarded the 2023 prize in economic sciences – demonstrated that access to the contraceptive pill played an important role in accelerating this revolutionary change by offering new opportunities for career planning.
#NobelPrize
Jared Coombs retweeted
Can your research be a work of art?
We're excited to announce our Paint n Sip event on Friday 13 October, hosted in the lead up to the Jo Underhill Art Competition! Starting from 4pm on the QBP Rooftop, all supplies will be provided, just bring your best idea! See you there!
Jared Coombs retweeted
At @EMCRA_IMB we are thrilled to host @FZMarques for a workshop entitled: Advocating for #genderequity –what you can do to drive #change. This is gonna be all about strategies, not just chatting! Register here: form.jotform.com/23261760128… @IMBatUQ
