Husband, Dad, Professor/Director. Chemical Biology, Drug Discovery, TPD, PROTACs, Molecular Glues, ADCs, Proteomics, & AI/ML. We do 💻🧪🧬 🐁 Views are my own.
Houston, TX
Joined February 2011
- Tweets684
- Following831
- Followers742
- Likes2.4K
Jin Wang 王津 retweeted
#AI-based structural modeling can guide chemists early for compound optimization, well before experiments reveal how a compound works. @JinWangLab, H Lin et al @bcmhouston @BCMCancerCenter @SandboxAQ @NatureComms #BCMPostdoc #MolecularGlues #Therapy bcm.edu/news/ai-structure-pr…
Jin Wang 王津 retweeted
A team of scientists at Baylor College of Medicine @bcmhouston and the tech company @SandboxAQ has developed a method for discovering #molecularGlues. @JinWangLab, H Lin et al @BCMCancerCenter @NatureComms #BCMPostdoc #Therapy cen.acs.org/pharmaceuticals/… @genengnews
When the sucking kicker missed the FG, I knew it would the same script!! Why can’t #OSU get a legitimate kicker!!!
Jin Wang 王津 retweeted
The @JinWangLab, H Lin et al developed a new analytical tool to optimize the potency and selectivity of drugs. #drugDesign @NatureComms @GENbio genengnews.com/topics/drug-d…
Congrats again to Yang Gao and the entire team for their pioneering research! Stay tuned for more of our work on this exciting target.
Interestingly, using the biochemical assays developed in this publication, we tested ZYS-1 (which I noted last week is not a genuine ADAR1 inhibitor) and confirmed it fails to inhibit ADAR1 even at concentrations as high as 1 mM.
Yang is a truly exceptional structural biologist, and I'm privileged to collaborate with his team on this target. Building on these mechanistic insights, we're making excellent progress developing ADAR1-targeted therapeutics.
This research elegantly demonstrates that ADAR1's activity depends not only on sequence but also on RNA-duplex length and structure. These findings are particularly significant given the enzyme's critical role in regulating innate immune responses.
Their recent Molecular Cell publication, "Biochemical Profiling and Structural Basis of ADAR1-mediated RNA Editing," provides atomic-resolution insights into how ADAR1 interacts with endogenous RNA substrates.
Congratulations to Xiangyu Deng and Yang Gao at @RiceUniversity for their outstanding work unraveling the complexities of RNA editing! Biochemical profiling and structural basis of ADAR1-mediated RNA editing: Molecular Cell cell.com/molecular-cell/full…
This underscores the need for target-specific assay validation in drug discovery. Join the conversation and read our full preprint for a detailed discussion. #ADAR1 #DrugDiscovery #RNAEditing #CancerResearch #AssayValidation
Our results revealed that ZYS-1 does not inhibit ADAR1 activity at concentrations up to 1 mM, challenging previous conclusions based solely on binding data.
In our study, we employed a rigorously validated ADAR1-specific biochemical assay that directly quantifies inosine formation on physiological dsRNA substrates.
Wang et al. used an ADA assay, which is designed to measure free inosine, not inosine incorporated within dsRNA. This calls into question the assay’s suitability for ADAR1 activity.
ADAR1 is a key RNA-editing enzyme that converts adenosine to inosine in dsRNA—a process essential for modulating innate immunity and a highly pursued target in cancer therapy.
Excited to share our new preprint on @biorxivpreprint , where we challenge the claim that ZYS-1 is a potent ADAR1 inhibitor, as reported by Wang et al. in @NatureCancer. Re: Concerns Regarding the Validation of ZYS-1 as a Bona Fide ADAR1 Inhibitor biorxiv.org/content/10.1101/…
Jin Wang 王津 retweeted
The NIH funds 4,400 active projects totaling $2.5 billion in Texas, much of it in Houston.
These cuts violate the law, hurt people, and undermine the very system of scientific research & groundbreaking advancements that we are so proud happen in #TX07.
houstonchronicle.com/politic…
Jin Wang 王津 retweeted
Today, we at OpenAI launched Deep Researcher and I wanted to share a deeply personal story about how amazing this tool is and how it will change the world. Trigger warning, related to cancer....1/9
Jin Wang 王津 retweeted
Excited to share that the AlphaFold 3 model code and weights are now available for academic use.
Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmind/a… 1/2
