SARS-CoV-2 evolved since 2019 to evade human biological defenses. Obviously. But not just how it’s been known previously. Also to evade our *Hardwired* human biolog. That is - Not to just evade our prior immune responses - but actually to better evade eliciting a robust response by our naive B cells. Looking at prepandemic cryopreserved samples, @jbloom_lab showed a 3x difference in the fraction of naive B cells responsive to the original Wuhan spike RBD protein compared to more contemporary Omicron lineages. This isn’t a simple “evade prior elicited antibody response” as we all understand This is actually - the virus mutates to help avoid detection altogether by humans - uniquely by evading aspects of the human germline encoded naive B cells responsive repertoire. They look at mice, for example, and saw no difference in ability of naive B cells to respond to the different variants Altogether it points to a world where we not only have immune imprinting to impair protection, plus the “regular” virus mutation to avoid existing immunity, but now mutation specifically to avoid hardwired human biology.