We💙membrane proteins! Using biochem, structural bio & C.elegans to study cell-cell communication, physiology & behavior, pain sensing & more @cornellmolmed
Ithaca, NY
Joined October 2021
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Could not be more exciting to share our latest findings about the mechanism of ATP release via the Pannexin 1 ion channel! Check it out 👉 The C-terminal activating domain promotes pannexin 1 channel opening | PNAS pnas.org/doi/10.1073/pnas.24…
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Our structural studies revealed that when exposed, the cytoplasmic domain, dubbed the c-terminal activating domain (CAD) can compete with the N-terminus to occupy a cytosolic pocket, which forces the N-terminus to reorient into the pore.
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We analyzed the electrostatic free energy of the cytosolic NTD, finding a positively charged region inside the pore that could accumulate negatively charged anions like ATP. In the reoriented NTD conformation this negative region is diminished reducing accumulation of ions there.
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Kawate lab retweeted
When nematodes become nemaTUBE holders 🪱🧪 (thanks for the nematode @korethegenius and the pun @jacqueline_ehr !)
🚨🚨check it out!! We got 3D models of our C.elegans localization studies!! 🪱@sarahkcodd
Congrats to our department-mates! We’ve been eagerly following this story at our @CornellMolMed seminars & so excited to see it out!
Check out our latest paper about glutaminase filament on @NatureComms! In this paper, we used #CryoEM and light scattering to show that the filament formation of glutaminase is coupled with its activity. nature.com/articles/s41467-0…
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Kawate lab retweeted
Its #LabFeatureFriday! Head over to our LinkedIn to learn more about Graduate Student @jacqueline_ehr and her work in the @KawateLab here at @cornellvet
bit.ly/3OQlej5
ALT Jacqueline Ehrlich smiling in front of an Apple desktop displaying images of her research.
We got our Philly (fill-y lol) ! Always a pleasure to share our work with the #BPS community. Headed back to 📍Ith feeling inspired & refreshed 💆♀️
Kawate lab is en route to #BPS2024! Let’s talk about Pannexins at Toshi’s platform session on Tuesday & @jacqueline_ehr poster presentation on Monday 🤜🤛
Kawate lab retweeted
Hear me out … a jewelry store that sells diamonds in the shape of your protein crystals
Kawate lab retweeted
Sometimes you have to purify proteins late on Friday night and sometimes your coworkers turn it into a pizza and dance party 🫶
Kawate lab retweeted
It looks like my proteins are having a meeting in the middle of my grid … a macromolecular assembly if you will
#NewProfilePic Our new logo makes its debut! Can anyone identify the membrane protein that Toshi used as his design inspiration??
Kawate lab retweeted
The @KawateLab is recruiting new students! Visit kawatelab.org/ to learn more about the research they do in Structure and Molecular Mechanisms, Physiology and Behavior, and Painometer Development.
We had a great time getting to know the incoming @CornellMBG students at the departmental retreat yesterday! We’re recruiting new students to the Kawate Lab in the department of @CornellMolMed. Join us if membrane proteins, C. elegans, or structural biology could be your thing!
