neuropath trainee @JHUPath @HopkinsMedicine | studying #brainmetastasis
Baltimore, MD 🦀
Joined June 2013
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Happy to share our latest paper exploring the correlation between ASXL1 mutations and H3K27me3 loss in a spectrum of CNS tumors.
link.springer.com/article/10…
Kevin Y Zhang retweeted
"Tails and Holes" (and eccentric & double nuclei) - All seen in a single case of "Melanoma" aspirated from a pancreatic lesion. (EUS-FNA)
Kevin Y Zhang retweeted
The TME @AACR meeting is focusing on how the systemic macroenvironment affects the local microenvironment to regulate cancer. A great start with an exciting Keynote by Ashani Weeraratna on the connection between aging, fibroblasts, and immune cells.
#AACRTumorenviron24
Kevin Y Zhang retweeted
Happy to share our final paper of 2024. This one in Cell Reports was led by @laura_hueser who wanted to know if exosomes from aged fibroblasts could impact melanoma. She is a meticulous scientist and took on a challenging project. This will be the paper I hold up to other… 1/2
Researchers alongside Dr. Ashani Weeraratna (@AshaniTW) report that aged fibroblast-derived extracellular vesicles play an important role in promoting a tumor-permissive microenvironment in #melanoma. #OpenAccess
🔗 @CellReports | bit.ly/4gpDLiz
Kevin Y Zhang retweeted
In a study published in @CellPressNews, researchers from Fox Chase Cancer Center and Johns Hopkins Kimmel Cancer Center showed changes that occur with age in male skin fibroblasts contributed to an increase in the spread of melanoma cells: bit.ly/3ZgEw7s @Yash_Chhabra
Kevin Y Zhang retweeted
So excited to share this enormous piece of work with you! Led by @YashChhabra while he was here at @JohnsHopkinsBMB (he’s now an assistant professor @FoxChaseCancer ). A thread!!
cell.com/cell/abstract/S0092…
Kevin Y Zhang retweeted
Here in Acta Neuropathologica, @KevinZhangMD+ describes ASXL1 inactivation and reduced H3K27me3 in CNS tumors via a retrospective patient cohort
These findings can be used to potentially validate personalized therapeutic approaches similar to myeloid malignancies
Kevin Y Zhang retweeted
In the August issue: The Interplay Between #ExtracellularMatrix Remodeling and Cancer Therapeutics. bit.ly/3M91iX0 @Prakash_UTwente @ShakedYuval @UTwente @TechnionLive.
Kevin Y Zhang retweeted
In this week’s podcast episode, Stanford neuro-oncologist Michelle Monje @michelle_monje explains how many deadly tumors depend on the nervous system’s electrical activity to grow and spread, presenting an exciting new line of attack for oncology research. neuroscience.stanford.edu/ne…
Immense gratitude to @last_name_lucas and the entire team: @jonathandudley @Karisa_Schreck @JordinaRT_md @BettegowdaMDPHD @NeuroEyepath
Kevin Y Zhang retweeted
Our opinion piece is out today, "The origin of novel traits in cancer"! Do the phenotypes come first and only later are they locked in by genetic or epigenetic changes? Insights from evolutionary biology are super useful for understanding cancer! cell.com/trends/cancer/abstr… #S_Frank
Kevin Y Zhang retweeted
Dr. Charles Eberhart (@NeuroEyepath) has spent 15 years researching pediatric brain tumors to identify new therapies that will improve post-treatment outcomes. Visit giving.jhu.edu/story/pediatr… to learn more about Dr. Eberhart, @JHUPath, and support for his work. #FacultyFriday
ALT A dark blue graphic with a headshot of Dr. Charles Eberhart, the Charlotte Wilson and Margaret Whitener Professor of Ophthalmology, and a quote from Dr. Eberhart that reads, "There is great potential for philanthropy to move the needle in targeting the disease and developing new cell-based models for drug testing."
Kevin Y Zhang retweeted
Great start to the weekend! Beautiful night for a water taxi cruise in the Baltimore Inner harbor with our #pathology residents @JHUpath! #pathX #pathtwitter #pathmatch #pathmatch25 #wellness @BmoreWaterTaxi
Kevin Y Zhang retweeted
See here how brain tumor cells dynamically recruit neurons during cancer progression with rabies-based retrograde tracing! #CancerNeuroscience #FluorescenceFriday
Kevin Y Zhang retweeted
Remarkable case of a tumor-to-tumor #metastasis, where a lung #cancer metastasized into a #meningioma. #pathology #neuropath #PathTwitter
Kevin Y Zhang retweeted
Neuropathologic Features and Underlying Medical Disease States of Spontaneous Subdural Hematomas in Adults: A Hospital Autopsy Case Series From a Single Tertiary Center
@ArchivesPath @AnnieAWu @KevinZhangMD @JoshuaDMateri @cjvand @cherrycyho
pubmed.ncbi.nlm.nih.gov/3906…
Kevin Y Zhang retweeted
Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️
nature.com/articles/s41586-0… @Gustavo_SFranca
Kevin Y Zhang retweeted
CSF with an “epithelioid” malignancy. Although, the first differential would be a metastatic adenocarcinoma (lung or breast), the findings here are consistent with metastasis from the patient’s known “melanoma”. (cytospin)
Kevin Y Zhang retweeted
What kind of metastatic brain tumor is this? (Hint: look at the nucleoli.) #pathology #neuropath #pathtwitter
