@KingLabIPD

News from the King Lab @UW. Part of @UWproteindesign and @UWBiochemistry. Some assembly required.

 Seattle, WA
kinglab.ipd.uw.edu
Joined June 2018
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Last week, Grace Hendricks successfully defended her dissertation and earned her PhD!
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🚨 new paper alert 🚨 Here we demonstrate increased anti-RBS neutralizing responses elicited by stabilized influenza H5 immunogens: bit.ly/4u8UxJl
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Yesterday Dane Zambrano successfully defended her thesis on hybrid lipid-protein nanoparticles! Excellent work Dr. Dane!!
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🚨new paper alert🚨 Here, we show how recently developed ML tools can be leveraged to design self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the oligomeric building blocks. Read more @PNASNews: doi.org/10.1073/pnas.2409566…
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Couldn't have asked for a lovelier day to break ground in our new lab downtown!🌞
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Thanks to Aia, Syed, Dixie, and James for joining us this summer as Rosetta Commons Undergraduate Researchers! We loved working with you these past 10 weeks and wish you the best as you head back home!
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🚨 new paper alert 🚨 We present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances! This project was led by Dr. Sanela Rankovic is out now in Nature Materials: tinyurl.com/yj8t476d
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Congrats on graduating Priya! After working in the lab for 3 years on vaccine adjuvants targeting the CD40 signaling pathway in germinal centers, she earned a Distinguished Researcher in Biochemistry award! Now she's off to work on flu vaccines at NIAID’s Vaccine Research Center.
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There's a new doctor in town, Cameron Criswell defended her PhD thesis last week! 🥳 Congratulations on all your hard work Dr. Criswell!
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Our very own Grace Hendricks gave an excellent talk about her work on mRNA-launched nanoparticles at the Keystone Symposium on Vaccinology in Washington, DC today!
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On Monday, the lab celebrated "Cinco de Cara" in honor of @chao_cara successfully defending her PhD thesis! 🥂 In addition to making MERS vaccines, Cara is a beloved member of the lab who often shares tasty baked goods and infectious laughter. Congratulations, Dr. Chao!
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Enjoying the blue skies in Seattle today 🌞
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Congratulations to Dr. Marti Tooley! 🍾 On Tuesday, Marti defended her PhD thesis, a real tour de force of protein design and immunology. We are SO proud of Marti and very grateful for the crucial role she has played in cultivating such a welcoming lab culture. Cheers! 🥂
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Hard to believe it has already been three weeks since Naveen defended his PhD thesis!! 🥳 To celebrate, the lab visited a nearby farm for some quality time with baby goats and highland cows🐐🐮
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The peer-reviewed version of Chloe's manuscript is now online @NatureComms! Check it out here: rdcu.be/d8dij.
King Lab
@KingLabIPD6 Sep 2024
Protein-based agonists generated from our de novo protein minibinder pipeline bind to human #TLR3 with nanomolar affinities. This collaborative project was led by recently graduated Dr. Chloe Adams and is out now on @biorxivpreprint: biorxiv.org/content/10.1101/…

De novo design of protein minibinder agonists of TLR3

Toll-like Receptor 3 (TLR3) is a pattern recognition receptor that initiates antiviral immune responses upon binding double-stranded RNA (dsRNA). Several nucleic acid-based TLR3 agonists have been...

biorxiv.org
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Huge congratulations to freshly minted, Dr. Mark Langowski! 🍾 On Tuesday, Mark defended his thesis entitled "Computational Design of Vaccines against Plasmodium falciparum Malaria." Mark is a scientific powerhouse, and we are so incredibly proud of him!
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One of the many King lab maxims:
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