Is quantification, not instrumentation, what holds mass spec imaging back in food safety testing? This week: wastewater drug monitoring, siRNA methods, RAFA 2026 previews and more. 📚 Catch up: hubs.li/Q04C7Sl10 #LCGC #Chromatography

Your “100% Arabica” coffee might secretly have Robusta hiding in it. Nicolai Zederkopff Ballin breaks down how chromatography catches food fraud using maximum tolerable levels. Read here ➡️ hubs.li/Q04C7SRH0 #LCGC #FoodFraud

siRNA method development went from about two weeks to about three days. Ed Ahearne of AstraZeneca is using automation, ML and Bayesian optimization to go further. 🧬 See how: hubs.li/Q04BY-940 #LCGC #Chromatography

Acetonitrile or methanol, which one wins for your separation? Michael Dong compares their chromatographic properties in the latest installment. Watch it here: hubs.li/Q04BT_Q-0 #LCGC #HPLC

Can MSI show exactly where a contaminant sits inside food, without staining? Laura Righetti says yes, but quantification, not instrumentation, is still what keeps it out of routine food safety testing. Find out what else she thinks here: hubs.li/Q04BTpMG0 #LCGC #MassSpec

Nearly half of Australians aged 14+ have tried an illegal drug. Richard Bade and Malcolm McLeod explain how LC–MS/MS detects drug trends in wastewater. 🔬 See how it works: hubs.li/Q04BK0Ph0 #LCGC #Chromatography

Building an LC pressure troubleshooting app used to take coding skills. Dwight Stoll says LLMs have “obliterated” that barrier. 🛠️ See the free tool: hubs.ly/Q04BKT8b0 #LCGC #HPLC

Can AI really take over peptide method development? Piotr Alvarez says it could compress months of work into weeks, or even days, with software next running column & mobile-phase screening on its own. Watch here➡️ hubs.li/Q04BLHhx0 #LCGC #GLP1

What stands in the way of reversed-phase success in drug analysis? Michael Dong tackles it in part 5 of his HPLC video series. 🎥 Watch the video: hubs.li/Q04BxMtT0 #LCGC #HPLC

This week’s best of LCGC: greener affinity chromatography, AI and machine learning in separation science, GLP-1 peptide robustness, and food nontarget screening. 📚 Catch up on the top stories: hubs.li/Q04Bpf9l0 #LCGC #Chromatography

Is separation science well suited to AI & ML, or are we forcing the fit? Gert Desmet returns for part 2 of AI ML Now, exploring whether the field should move past black-box AI toward physics-informed ML. Watch here ➡️ hubs.li/Q04BnXKc0 #LCGC #Chromatography

Why are buffers most often used in Mobile Phase A for pharmaceutical HPLC? Michael Dong explains in part 4 of his HPLC video series. 🎥 Watch the video: hubs.li/Q04BgtWV0 #LCGC #HPLC

Food samples can yield thousands of unidentified chemical features. Anneli Kruve explains how MS2-derived molecular fingerprints are helping labs prioritize which ones are actually worth investigating. Read more here ➡️ hubs.li/Q04BgwFK0 #LCGC #Chromatography

AI and ML are reshaping separation science, but how much is real progress vs. hype? Gert Desmet opens our new series AI ML Now by tackling common misconceptions about what AI/ML can actually do for chromatographers. Watch here ➡️ hubs.li/Q04B7rrz0 #LCGC #Chromatography

Can you trust concentrations estimated without authentic standards? Jan Christensen on predicted response factors in non-targeted screening and why training data is the challenge. 🎥 Watch the interview: hubs.li/Q04B6GM70 #LCGC #Chromatography

Part 2 is here. Novartis’s Martina Lioi explains how pairing denaturing ion-pair HILIC with RP gives complementary separation for impurities in fatty acid-conjugated siRNAs. Watch part 2 here ➡️ hubs.li/Q04B032k0 #LCGC #Chromatography

Environmental samples can wreck even sensitive detection methods. Jan Christensen explains how multidimensional chromatography cuts ion suppression by separating salts & coeluting compounds from target analytes. Watch it here ➡️ hubs.li/Q04z_K3X0 #LCGC #Chromatography

Why do GLP-1 peptide methods fail to transfer between labs? Dwell volume, TFA prep, and flow rate and temperature choices all play a role in peptide robustness. 💬 Read the panel’s take: hubs.li/Q04zW1-Z0 #LCGC #Chromatography

Can affinity chromatography go green? David Hage, Sanduni Heenkenda & Zoe Zingler of the University of Nebraska-Lincoln on how green chemistry principles are reshaping the technique. Dive in here➡️ hubs.li/Q04zW2qJ0 #LCGC #GreenChemistry

Kinjal Bhatt and Ina Varfaj on what a successful career in chromatography really looks like: energizing work and personal balance, not just publications and promotions. Find out what else they thought right here➡️ hubs.li/Q04zQnp60 #LCGC #WomenInChromatography