The Lehtiö Lab retweeted
Tutkijamme ovat onnistuneet kehittämään yhdisteen, joka estää koronaviruksen lisääntymisen ihmissoluissa. Yhdiste on tuoreiden tutkimustulosten perusteella erittäin lupaava aihio koronaviruslääkkeiden kehitykseen.
#UniOulu #koronavirus @LabLehtio
oulu.fi/fi/uutiset/oulun-yli…
Mac1 inhibitor represses #SARSCoV2 replication! #PARP #drugdiscovery @FehrLab
doi.org/10.1021/acs.jmedchem…
Our paper on oligomerization of DTX3L E3 ubiquitin ligase and how this allows DTX3L-PARP9 compex to recognize ADP-ribosylated proteins is now online in Protein Science. Structure was solved with sulphur SAD @DiamondLightSou #PARP #BiocenterOulu #UniOulu
dx.doi.org/10.1002/pro.4945
Our paper on #PARP HPF1 interaction inhibitors and assay is now online. Mainly some validation with full-length enzyme and activity added to the preprint version.
nature.com/articles/s41598-0…
Small contribution from us to a collaborative study on the design of new small molecule inhibitors. Naturally using #PARP as an example. #fbmm #biocenteroulu
onlinelibrary.wiley.com/doi/…
The Lehtiö Lab retweeted
@UniOulu @LabLehtio tekemälle #parp lääkeaihiokeksinnölle on myönnetty #patentti Euroopassa. Kyseessä on pienimolekyylinen kemiallinen yhdiste, joka tehostaa syövän hoitoa, kun sitä annetaan soluille yhdessä solumyrkkyjen kanssa.
➡ Lue lisää - linkki kommenteissa
#oulu
A doctoral researcher position available in our team focusing on mono-ART's and their complexes. #PARP #fbmm #structuralbiology
oulunyliopisto.varbi.com/en/…
How does #DTX3L oligomerize and why is it needed? A preprint about this is online #fbmm #biocenteroulu #PARP
doi.org/10.1101/2023.11.29.5…
A different kind of preprint. This is about the MSc crystallography course we organize in Oulu. Actually at the moment the R-factors start to be below 20% for some students :) #fbmm #biocenteroulu @UniOulu
doi.org/10.35542/osf.io/6g7f…
A preprint is available about the HTS assay to find inhibitors for #PARP HPF1 interaction developed and carefully optimized by @SaurabhSinghDh8 . We even found some early hit molecules.
#drugdiscovery #FBMM #BiocenterOulu @SuomenAkatemia
doi.org/10.1101/2023.11.14.5…
How DTX3L-PARP9 complex can bind dual ADP-ribosylated peptides? Nice collaboration paper with @LeidenADPr and Paschal team.
#BiocenterOulu #PARP #FBMM
pubs.acs.org/doi/10.1021/acs…
Saurabh is representing our team! The course is likely extremely nice based on the programme and the picture.
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We have 3 doctoral researcher positions available in projects studying human mono-ADP-ribosyltransferases. These are funded by the #BiocenterOulu spearhead project and by the Research Council of Finland. @SuomenAkatemia
@UniOulu #PARP #FBMM
oulunyliopisto.varbi.com/en/…
A preprint now available for the macrodomain inhibitor which inhibits coronavirus replication. Great collaboration between teams from @UniOulu, @UnivOfKansas and @McDanielCollege #PARP #Drugdiscovery #SARSCoV2
doi.org/10.1101/2023.08.28.5…
The paper on the FRET-assay and discovery of DTX3L E3 ligase inhibitors is now published. Congrats and big thanks especially to Carlos! #BiocenterOulu #UniOulu #drugdiscovery #LifelongHealth
doi.org/10.1016/j.slasd.2023…
The Lehtiö Lab retweeted
Lloyd Ruddockille tutkimuksen kaupallistaminen näyttäytyi pitkään Tähtien sodasta tutun pimeän puolen kaltaisena pahana voimana. Nyt hän kertoo työskennelleensä jo yli vuosikymmenen ajan yritysten kanssa yhteistyössä. Mikä sai mielen muuttumaan?
#UniOulu oulu.fi/fi/uutiset/akateemin…
The Lehtiö Lab retweeted
We had an incredible time at the PARP2023 advanced course! 🌟 Engaging talks, thought-provoking discussions, and inspiring connections made. Already reminiscing about the fantastic moments! Looking forward to reconnecting with all of you in Strasbourg 2025. #PARP2023
