@LabReuben

official twitter account of the Shaw Lab at the Salk Institute in La Jolla anti-cancer anti-diabetes anti-aging aey oh let’s go.

 La Jolla, CA
salk.edu/scientist/reuben-shaw/
Joined January 2020
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  • Followers1.5K
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Shaw Lab August Journal Club. Taking the new paper from @YanxiangGuo panel by panel. Still so much to learn about LKB1, and you can’t beat good discussions and lunch together! nature.com/articles/s41467-0…
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Replying to @KurianLab
The plan is ~5 min. But actually it goes according with the group interest in the discussion
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biorxiv.org/content/10.1101/…
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nature.com/articles/s41467-0…

Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization...

Nature Communications - Semaglutide is used for glucose control and weight reduction. Here, the authors show that it enhances myocardial metabolism by targeting Creb5/NR4a1, protecting against...

nature.com
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nature.com/articles/s41586-0…

Krause corpuscles are genital vibrotactile sensors for sexual behaviours

Nature - Krause corpuscles of the clitoris and penis are highly sensitive mechanical vibration detectors that mediate sexually dimorphic mating behaviours in mice.

nature.com
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Some of the papers discussed:
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Shaw lab August Rapid Fire Journal Club. Each one briefly talks about a cool paper read in the last month. Lots of learning, fun & new ideas!! We talked glutamine metabolism, GLP-1, cancer metabolism. But anything interesting that was read is valid, even Krause corpuscles!
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The Shaw Lab welcomed the new members and celebrated the great So Cal summer in the Annual Shaw Lab picnic. Great time together at San Dieguito park last weekend!! #CancerResearch #ShawLab #SummerFun @salkinstitute
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🎇Congratulations to Salk Professor Ronald Evans for winning this year's Japan Prize in Medical Science and Pharmaceutical Science for his groundbreaking discovery of nuclear hormone receptors! @JapanPrizeAward #JapanPrize #scientificbreakthrough salk.edu/news-release/salk-i…
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The spring issue of Inside Salk features a profile of Reuben Shaw @LabReuben & his 2003 discovery that led to a job offer from the Salk Institute. Today Shaw is a professor and director of Salk's National Cancer Institute (NCI)-designated Cancer Center. bit.ly/3ID16Ox
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Salk Prof Reuben Shaw @LabReuben, first author Nazma Malik, and team discovered the protein FNIP1 links cellular powerhouse damage to repair during metabolic stress, w/ broad disease implications spanning from #diabetes to #cancer to #neurodegeneration bit.ly/3H0z8LF
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with accompanying music from 20 years ago that match the mood - Brand New "The Quiet Things That No One Ever Knows" youtu.be/qgtkPKZ2OPk

Brand New - The Quiet Things That No One Ever Knows (Official Video)

Brand New's official music video for 'The Quiet Things That No One ...

youtube.com
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This paper is the last* piece of the puzzle answering: How does AMPK sense mitochondrial stress and ultimately replace damaged mitochondria with shiny new ones?
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New paper from the Shaw lab- star postdoc @NazmaInzais bookends a series of papers from our lab over the last 12 years Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1 science.org/doi/10.1126/scie…

Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1

The energy-sensing protein kinase AMPK also regulates organelle biogenesis.

science.org
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