@LabWilhelm

Research group studying metabolic and dietary control of mucosal immunology - led by Dr. Christoph Wilhelm at the University of Bonn

 University of Bonn
ukbonn.de/42256BC8002AF3E7/direct/ag-wilhelm-klinische-chemie-und-klinische-pharmakologi
Joined December 2019
  • Tweets242
  • Following443
  • Followers1.1K
23Media
Wilhelm Lab retweeted
Cell Metabolism@Cell_MetabolismSep 23
New! Online now: Adipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic health dlvr.it/TVcSWf
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Wilhelm Lab retweeted
SchabbauerLab@SchabbauerLMay 18
We are excited to see our beloved study on Macrophage Arginine metabolism in Neuroinflammation published today in #NatureImmunology. nature.com/articles/s41590-0…. It is time to celebrate 🍷🍻🥂

Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation

Nature Immunology - Kerndl and colleagues identify that arginase 1-expressing monocyte-derived cells mediate arginine catabolism and detrimental effects during experimental autoimmune...

nature.com
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Wilhelm Lab retweeted
Wen Zhang@wenzhang1120Feb 12
Honored to see our recent Nature study on neuro-epithelial circuits in anti-helminth immunity highlighted in this excellent News & Views. Many thanks to the authors @LabWilhelm for the thoughtful synthesis. doi.org/10.1038/s41590-026-0…
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A nice write-up from Nature Immunology about our recent paper! nature.com/articles/s41590-0…

Tuft cells feel the pain

Nature Immunology - Type 2 immunity in the gut is regulated by an interplay between epithelial and immune cells. A recent Nature paper shows that pain receptors amplify this response by promoting...

nature.com
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Wilhelm Lab retweeted
Immunity@ImmunityCP10 Dec 2025
Online now: Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation dlvr.it/TPlGbt

Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic...

Immune cells must modulate their metabolism to adapt to tissue constraints. Wientjens et al. show that allergen-induced ILC2s and Th2 cells require cysteine-driven glutathione synthesis to prevent...

cell.com
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Thrilled to announce that our #SFB1454 got funding @UniBonn @IIIBonn #Metaflammation
DFG public | @[email protected]@dfg_public25 Nov 2024
Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten: ➡️dfg.de/de/service/presse/pre…
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Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation @Fer_NK_nando @TimMcCulloch nature.com/articles/s41467-0…
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🚨 last weeks 🚨 1 phd position available in our Lab ! If you are interested in tumor immunology and immunometabolism contact us … info 👇 … 🙏 RT
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Wilhelm Lab retweeted
Mackay Lab@LMackayLab15 Oct 2024
1/ 🚨 Hot off the press! 🚨Our new paper, led by @ObersAndreas & @maxevrard, is now live in @ImmunityCP! 🧬 Curious how CD8+ tissue-resident memory T cells (TRM) adopt their fate in different organs? Let’s dive in! 🧵👇 authors.elsevier.com/c/1jw~j…
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Not the first and likely not the last review on tuft cells. But for sure the most recent one, published in @NatRevGastroHep: Kalle and @XiaogangFeng did a great job summarizing recent findings related to tuft cells nature.com/articles/s41575-0… full-text access: rdcu.be/dVaOi
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We are looking for a highly motivated PhD Student! 🤩 If you are passionate about science and interested in tumor immunology and metabolism… join us in Bonn! 👩🏻‍🔬👨‍🔬 please share🙏
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We describe that Il-9 and Il-21 have partially overlapping and synergistic effects in asthma. Check out doi.org/10.1016/j.jaci.2024.… Nice collab with @BenjaminMedoff in MGH and @argenxglobal Revive Il-9 !
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Very proud of our discovery: a heat-induced CNS plasticity mechanism that drives heat tolerance. I had hoped for it to come out 2 years ago, but I tried too hard with @nature and after several rounds of revisions they rejected it – see/judge yourself. biorxiv.org/content/10.1101/…

Thermally-induced neuronal plasticity that mediates heat tolerance

Heat acclimation is an adaptive process that improves physiological performance and supports survival in the face of increasing environmental temperatures. Understanding the underlying mechanisms...

biorxiv.org
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Wilhelm Lab retweeted
Brenner Lab@Brenner_Lab9 Jul 2024
Excited to share our new publication @Cell_Metabolism! GSH in Th17 cells is crucial for gut barrier integrity, controls mitochondrial ROS & transcription, ATP & links to IL-22 translation. Huge thanks to Lynn Bonetti @LIH_Luxembourg & our collaborators. cell.com/cell-metabolism/ful…

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

Bonetti et al. show that glutathione’s (GSH) control of mitochondrial reactive oxygen species (ROS) in Th17 cells is critical to maintain intestinal barrier integrity during bacterial gastrointesti...

cell.com
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Wilhelm Lab retweeted
Dr Becs@ScientistBecs14 Jun 2024
Thrilled to have this story out online @ImmunityCP!! Together with @SunLab_Official, we highlight how dietary fasting improves NK cell anti-tumor immunity and examine the tissue-specific processes that drive these improved responses 🧵cell.com/immunity/fulltext/S…

Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity

Dietary restriction is associated with improved elimination of cancer cells, and fasting regimens are being tested in clinical settings in combination with cancer therapies. Using a cyclic fasting...

cell.com
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nature.com/articles/s42255-0… Excited to share our new paper on the discovery of MCT1 as a mediator of succinate uptake into brown adipocytes. We propose local plasma membrane pH gradients regulate systemic regulation by succinate.
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You are a PhD or a junior PostDoc? Participate to the 2024 ENII SUMMER SCHIOL on ADVANCED IMMUNOLOGY! #sardinia #immunology – at Bonn, Germany
Bruno Silva-Santos@BSilva_Santos13 Feb 2024
For PhD students and junior post-docs: registration is open until 1st March for the best Summer School in Immunology ;) See you in Sardinia :)
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Curious how mice decide which ambient temperature they prefer? Our new preprint does not have all the answers to this question but the study of @hummuscience uncovers differential roles of two temperature-sensitive TRP ion channels in decision making👇 biorxiv.org/content/10.1101/…

Diverging roles of TRPV1 and TRPM2 in warm-temperature detection

The accurate perception of innocuous temperatures, particularly those experienced as pleasantly warm, is essential for achieving thermal comfort and maintaining thermoregulatory balance. Warm-sensi...

biorxiv.org
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Excited to share our research that describes a variety of mechanisms that CD4+ T cells can employ to target melanoma!
Science Immunology@SciImmunology19 Jan 2024
A new study describes how some CD4 T cells can exhibit killer behavior against melanoma, more closely resembling their cousins, CD8 T cells. @egbawden Learn more: scim.ag/5A8
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We are very happy to share our review on methodologies to investigate the host-pathogen interaction from a metabolic perspective .. amazing collaboration with @Demangel_Lab … doi.org/10.1016/j.micinf.202…
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