Improving and individualizing medicine through translational systems biology. Mass spectrometry, Multi-Omics, Diagnostics. Mayo Clinic. Views are personal.
Rochester, MN
Joined October 2022
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Akhilesh Pandey Lab retweeted
That's a wrap on #HUPO2026 Singapore! 🎉 Congrats to Katherine Madden (🥇 Poster Competition), Elena Kratz (runner-up) & Kathrin Korff (Thesis Competition runner-up). And to alumni Jesper Olsen, Akhilesh Pandey & Florian Rosenberger, & to Judith Steen, on their HUPO awards! 👏
Thank you to every speaker who shared their research, every delegate and every partner.
This congress would not have been possible without you. Together, we've pushed the field of proteomics forward in ways that will echo well beyond Singapore.
See you next year in Italy!
#HUPO2026 #Proteomics
Just out in Journal of Inherited Metabolic Disease @JIMD_Editors: our study on multiplexed mass spectrometry-based glycoproteomics of serum proteins in SRD5A3-CDG, a disorder of dolichol synthesis. We found hypoglycosylation across the serum glycoproteome. onlinelibrary.wiley.com/doi/…
Significant decrease in N-glycopeptides was seen in haptoglobin, ceruloplasmin and albumin among others. These site-specific glycopeptide changes may provide new biomarkers and insights into SRD5A3-CDG pathophysiology. Led by Anu Jain @Dr_Anu_Jain from our team.
Excited to share our latest work demonstrating an imaging mass spectrometry workflow combining #MALDI with #IHC. We deployed photocleavable mass tag-conjugated antibodies to analyze spatial distribution of ER, PR, and HER2 proteins in breast cancer analyticalsciencejournals.on…
This method enables detection of multiple clinically relevant markers at once in a single #FFPE section. It is concordant with IHC and offers new possibilities for multiplexed spatial biomarker resolution. Led by Kiran K. Mangalaparthi @mkirankumar89 and Daigo Gunji from our team
Excited about our research now published in Molecular Genetics & Metabolism! N-linked glycosylation of albumin is altered in congenital disorders of glycosylation with #biomarker potential. #CDG linkinghub.elsevier.com/retr…
Albumin carries N-glycans at two non-canonical sites: N68, N123. We show changes in albumin glycopeptides consistent with biochemical defects in type I, II and mixed type CDG. These new targets may complement transferrin testing in diagnosis and monitoring. #RareDisease #MassSpec
Congratulations to Kishore Garapati @kilroykishore Anu Jain @Dr_Anu_Jain Neha Joshi @Salvation_007 and others from our team and to our collaborators!
Published in the American Journal of Hematology @AjHematology: our work on multiple #myeloma showing Genomic Proximity Mapping can confirm FISH findings and also detect clinically relevant structural variants, CNVs, ploidy changes onlinelibrary.wiley.com/doi/…
These extra findings (IGH rearrangements, TP53 loss, 1q gain, chromothripsis) can alter risk stratification and treatment decisions. Proximity mapping may improve diagnosis and enable more precise, mutation-guided therapy. Led by Richard Kandasamy @richardKumaranK from our team
Excited to share our research on the mu chain of hemoglobin published in Blood Red Cells & Iron @BloodPortfolio! Once considered a pseudogene, we show that HBM encodes a protein that is produced in gestation at levels similar to embryonic globins sciencedirect.com/science/ar…
Using targeted mass spectrometry-based measurement of all hemoglobin chains, we discovered that the levels of #hemoglobin mu chain are increased in patients with alpha thalassemia where the HBM gene is spared from deletion, indicating a compensatory role and #biomarker potential
Happy to share our study on a novel approach for targeted measurements of post-translational modifications of single cells published in Journal of Proteome Research @JProteomeRes and led by @DongGimun from our team doi.org/10.1021/acs.jproteom…
We present a targeted strategy combining tandem mass tag multiplexing with SureQuant-based triggered MS/MS using super heavy TMT-labeled peptides as triggers, enabling robust quantitation of histone PTMs with improved analytical throughput #Singlecellproteomics
Excited to share our new study published in Blood Cancer Journal @BloodCancerJnl! Using @OlinkProteomics we profiled bone marrow plasma from #MultipleMyeloma & monoclonal gammopathy of undetermined significance patients to uncover specific protein signatures #MyelomaResearch
Immune proteins rise with severity while metabolic proteins rise early, and are potential #biomarkers for early detection of plasma cell disorders. Led by Joel-Sean Hsu @hsu_joelsean and Richard Kandasamy @richardKumaranK from our group nature.com/articles/s41408-0…
Akhilesh Pandey Lab retweeted
.@MayoCancerCare researchers will present their latest radiation oncology findings at the 2025 American Society for Radiation Oncology (ASTRO) Annual Meeting, scheduled to be held Sept. 27–Oct. 1 at the Moscone Center in San Francisco.
Learn more: newsnetwork.mayoclinic.org/d…
Congratulations to Kishore for presenting our glycoproteomics work in congenital disorders of glycosylation at the Ehlers Symposium & BMB Research Retreat at Mayo Clinic — and for winning a Best Poster Award! 🏆 Exciting recognition for outstanding science! @kilroykishore
Shoutout to Joel-Sean Hsu from our team for presenting our ongoing research on IMiDs in multiple myeloma at the Ehlers Symposium & BMB Research Retreat at Mayo Clinic. Grateful for the opportunity to share our work and connect with the community 🧑🔬🧪
