Studying how organs form & making artificial kidneys. Group leader at the Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research.
Joined February 2020
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Nils Lindstrom retweeted
Synthetic Organizers Aid Creation of Reproducible Kidney Organoids from Stem Cells
Synthetic organizers provide a way to control formation of #kidneyorganoids as more reliable models for studying disease, evaluating potential therapies
@LindstromLab @USC
hubs.li/Q04nBGTy0
Nils Lindstrom retweeted
Kidney cells from stem cells. Yep, it's happening.
Nils Lindström, PhD, of the @LindstromLab at @USCStemCell explains the process of turning stem cells into organoids, a pathway to identifying new treatments for kidney disease.
Nils Lindstrom retweeted
How do you break symmetry along a cell planar axis? Of course WNT/BMP/FGF/NOTCH compete and talk. Each nephron is like an embryo patterning along its AP axis. @LindstromLab @USCStemCell
doi.org/10.1101/2025.03.29.6…
Nils Lindstrom retweeted
Pleased to be sharing this chapter written with Nils @LindstromLab for Current Topics in Developmental Biology! Here we dive into how #nephrons establish proximal-distal patterning during #KidneyDevelopment & what this means for #StemCell-derived nephrons: authors.elsevier.com/a/1kWLp…
Nils Lindstrom retweeted
Check out Mark Corkins’ collaborative preprint with @AdRoMora from our lab and MaryAnne Achieng from @LindstromLab using comparative single-cell sequencing and in situ to create this beautiful spatial model of the developing adult frog kidney!
biorxiv.org/content/10.1101/…
Nils Lindstrom retweeted
The outer ear is a mammalian innovation but where did it come from? In our study in @Nature, @MathiThiru95 and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. nature.com/articles/s41586-0…
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Nils Lindstrom retweeted
tldr: we identify a new organizer activity in vivo in human developing kidney, noticed the lack of said organizing activity in kidney organoids and reconstituted the organizer action in vitro via synthetic organizers - longer thread on bluesky!
@LindstromLab
Nils Lindstrom retweeted
Genes aren’t the sole driver instructing cells to build multicellular structures. In a paper in @NatureComms, @USCStemCell scientist @LeonardoMorsut and @Caltech computational biologist Matt Thomson characterize the influence of cell density. stemcell.keck.usc.edu/exerti…
Nils Lindstrom retweeted
I am excited to share our work discovering neuro-endothelial cells (NECs) - a subtype of #endothelial cells that regulate #brain and #kidney blood flow and #immune balance - now available online! Movie: NECs (green) in the mouse motor cortex #vasculature. biorxiv.org/content/10.1101/…
Nils Lindstrom retweeted
How similar is kidney development in humans and in lab mice that form the foundation of basic medical research? In a new study published in @Dev_Cell, @USCStemCell scientists probe this question. @AndyMcMahonLab @LindstromLab @KeckSchool_USC stemcell.keck.usc.edu/study-…
Nils Lindstrom retweeted
We have two 1-year positions with a 1-year renewal option available for clinical trainees interested in conducting research related to stem cell biology and/or regenerative medicine in one of the leading labs @USCStemCell. @KeckSchool_USC stemcell.keck.usc.edu/2024-c…
Nils Lindstrom retweeted
A new @USCStemCell study, led by Zhongwei Li's Lab (@LiLab_Kidney), introduces a new and improved way to grow the cells that give rise to the kidney’s filtration system. @AndyMcMahonLab @LindstromLab @ukrocharity @CellPressNews @NIH_CommonFund stemcell.keck.usc.edu/usc-le…
Nils Lindstrom retweeted
Celebrating #WorldKidneyDay with @ukrocharity and Zhongwei Li’s lab @USCStemCell and @KeckSchool_USC. @LiLab_Kidney and colleagues @AndyMcMahonLab, @LindstromLab and @JPetiPeterdi are progressing on generating a transplantable kidney from human stem cells to replace dialysis.
Nils Lindstrom retweeted
To democratize access to lab-grown organ-like structures known as organoids and other advanced stem cell and transcriptomic technologies, @USCStemCell will launch the CIRM ASCEND Center. @CIRMnews stemcell.keck.usc.edu/3-95-m…
Nils Lindstrom retweeted
Through their KidneyX prize, Dr. Nils Lindström @LindstromLab and his team at the University of Southern California are advancing the next generation of functional artificial kidneys using stem cells. Watch to learn more youtu.be/eoANNmUtrHs?si=ULie…
Nils Lindstrom retweeted
USC's Department of Stem Cell Biology and Regenerative Medicine (stemcell.keck.usc.edu/) is recruiting outstanding tenured faculty in the broad areas of developmental and stem cell biology and regenerative medicine. To apply, visit usccareers.usc.edu/job/los-a…
Nils Lindstrom retweeted
Super excited to share our new paper Unified Mouse and Human Kidney Single-Cell Expression Atlas Reveal Commonalities and Differences in Disease States by Jianfu Zhou journals.lww.com/jasn/abstra…
Nils Lindstrom retweeted
Everyone speaks about AKI, few speak about AKD, but many pts develop AKD w/o AKI. AKD +/- AKI has important consequences on mortality and subsequent CKD.
Incidence and prognosis of AKI versus AKD among 71,041 inpatients academic.oup.com/ckj/article…
Nils Lindstrom retweeted
Important concepts because low nephron no is a 🔝RF for HTN, proteinuria of any cause, pre-eclampsia, DKD, progression of CKD, AKI/CKD transition etc etc.
Nephrons develop by log2 , so most come from the last rounds of branching = last wks of pregnancy @valerie_luyckx
