Scientist and professor. Follow for science, health, and academic reform • dr.jason.locasale@gmail

Raleigh, NC
Joined March 2015
Jason Locasale retweeted
So true.
After you are abandoned by a trusted institution and publicly shamed, the headlines and mobs eventually fade. What you are left with is isolation. People who claimed to be your friends abandon you. Very few will say anything positive about you. People generally pretend you are dead. Others dismiss or worse take credit for your work and try to write you out of history. Vultures swoop in from every direction. This is what happens when fourth-rate administrators make decisions affecting people’s livelihoods without concern for what they are doing to their lives. These are scientists who were among the best in the world at what they did. They passed up careers in pharma, finance, tech and administration that could have paid them vastly more for their skills. When I was younger, people in my programs who gave up on science early went on to make fortunes on Wall Street, in biotech, and in Silicon Valley. Those who stayed pursued their passion for the love of it at the cost of millions of dollars. When an administrator steps in and dismantles that life’s work, far more than a job is erased. Laboratories take years to build, and scientific problems take years to develop and eventually solve. Experiments, research materials, collaborations, and accumulated expertise cannot simply be restarted somewhere else. The field keeps moving while your work is stopped. The time lost is also the time lost that could have been spent making money - that part a court will never be able to figure out because juries are ordinary people not dedicated scientists. Then comes the gaslighting. People assume it must have been your fault because an institution like MIT or Duke is supposedly so trustworthy and meritorious that it would never do this to someone who was not guilty. Institutional prestige is a substitute for examining the evidence. I recently attended a meeting on academic freedome at MIT where Dorian Abbot’s name kept coming up as their fallen hero. They cited a cancelled lecture of his at MIT as their rallying cray. It was treated as an institutional catastrophe. It was insane. David was an afterthought among people supposedly concerned about the climate at MIT and self-appointed to change the culture there. They simply believed MIT’s PR messaging that they have always been focused on merit despite some small missteps like the canceling of a controversial lecture. I had to point out repeatedly that MIT is not the MIT they attended 30–50 years ago. The priorities reflected in its newer hires and leadership have moved far from the scientific excellence they associate with it.
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Jason Locasale retweeted
Replying to @LocasaleLab
There are some who would say that medical training is not long enough to learn all that is required to be a knowledgeable and skilful medical practitioner.
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So few people even know this side of biomedical research exists. @LocasaleLab is amazing at articulating this.
When I first entered biomedical research, I wanted to cure cancer. I believed the limiting factor would be the difficulty of the science - discovering new biology about the disease itself. I learned very quickly that this wasn’t true. The limitations wasn’t ideas or experiments. It was red tape and the corporatization of the medical centers. That became even clearer when I worked alongside biotech. I was shocked to see companies shop clinical trials across medical centers, negotiating for access to patients the way one shops vendors. Prestigious brands charged more. Lesser-known centers were cheaper. A year or more could be lost in contract negotiations alone. These were nonprofit medical centers, heavily funded by taxpayers, treating patients like retail assets while calling themselves public-spirited institutions. All of it delayed trials, delayed data, and delayed new medicines.
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Jason Locasale retweeted
Replying to @LocasaleLab
@LocasaleLab nails it: "A research enterprise that can be decimated by short-term budget changes was already broken." But here's the part Nature won't say as they cater to politics: Smart universities already knew this. They've seen the data for years: - Admin-to-faculty ratio: Up 300%+ since 1990 - Research reproducibility: <50% in many fields - Grant overhead: 40–60% goes to compliance, not labs - Output per dollar: Flat or declining So why didn't they fix it? Because the old model was lucrative. Federal grants = guaranteed revenue stream. Universities optimized for: - Maximizing grant volume (more overhead $) - Minimizing risk (safer, incremental research) - Growing admin (compliance, DEI offices, grant-writing support) Result: Bloat, not breakthroughs. What's changing: The competitive universities are adapting right now. You're seeing: 1) Research VPs replaced: Old guard optimized for grant volume. New leadership focused on output, commercialization, and private partnerships. 2) Admin restructures: Cutting compliance layers, streamlining overhead, reallocating $ to labs. 3) Shift to measurable ROI: Patents, spin-offs, industry partnerships. "How much did we discover?" vs. "How many grants did we win?" Why? Because boards aren't dumb. They see: - Federal funding under scrutiny - Private sector (AI, biotech, energy) hiring talent away - Alumni/donors asking "what did my money produce?" Universities that can't show productivity will lose talent, funding, and reputation. The survivors are moving now. Nature's problem: They're still defending the old model. Treat science as a victim of politics, demand more funding, ignore institutional rot. But the universities they're defending? The smart ones will reform. They know the system was broken. They just didn't have the incentive to fix it until the money got tight. Nature may catch on, probably after half their institutional subscribers disappear because they couldn't adapt. The outlook? Opportunity for people like Jason to reform research so it works.
Nature is pandering to a familiar political base. Framing the threat to U.S. science as primarily political misses deeper problems: a research enterprise that can be “decimated” by short-term budget or staffing changes was already broken - defined by administrative bloat, perverse incentives, and a profound crisis in scientific merit and reproducibility that long predates any administration. Treating science as a passive victim of politics avoids the harder truth: the credibility problem is real, and no amount of funding rhetoric can substitute for institutional reform.
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Jason Locasale retweeted
Excellent essay by @LocasaleLab for @brownstoneinst I share his concern that the soul of the American university is being lost to suffocating bureaucracy, administrative risk-aversion, political ideology, and primacy of financial and commercial interests. This is a leadership moment for university presidents and their boards. I hope they will rise to the challenge. @GeBaiDC What Broke University Science? brownstone.org/articles/what… via @brownstoneinst
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Great article and insight by @LocasaleLab University science did not just drift off course. It was slowly rebuilt into an administrator-centric, risk-managed business where grant volume, branding, and institutional optics often outrank actual discoveries.​ As someone training in pharmacology and toxicology and working on noncoding RNAs, it is hard not to recognize parts of this: high-impact, mechanistic work in metabolism, toxicology, and RNA biology can struggle for space when it does not neatly fit the dominant funding narratives. At the same time, I am deeply grateful that my PI has consistently taken real scientific risks when funding allowed, and even more grateful that some of those bets have already pushed important work in noncoding RNA and related areas forward instead of just playing it safe.​ For me, that is the hopeful counterpoint to this essay. The structures may be distorted, but individual scientists and labs still choose whether to treat grants as mere revenue streams or as chances to do ambitious work that actually moves a field. If universities cannot realign their incentives around that kind of risk-taking, new institutions will eventually arise that do, and they will inherit the most curious people and the most interesting science.
My latest article at the Brownstone Institute. University science broke when administrators replaced scientists, grant money replaced discoveries, and institutional branding became more important than truth. brownstone.org/articles/what…
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Jason Locasale retweeted
Powerful article by @LocasaleLab filled with truth bombs that apply equally to US medicine, public health system, and covid response. "The incentives reward exaggeration." "Everyone plays along because transparency would threaten the financial architecture of the entire enterprise." "The output-to-dollar ratio is far lower than the public is led to believe." "[Reform] will come from building leaner, more accountable institutions that prioritize truth over image management . . ."
My latest article in The National Review @NRO on what 60 Minutes got wrong about Harvard and the biomedical research industrial complex, and why the deeper issues in science can’t be fixed by throwing more money at broken institutions. nationalreview.com/2025/11/w…
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Jason Locasale retweeted
The "60 Minutes" piece wasn’t a celebration of science -- it was damage control. A carefully crafted story to reassure viewers that the old institutions still deserve their trust and money. | @LocasaleLab nationalreview.com/2025/11/w…
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Jason Locasale retweeted
That’s true. Scientists, physicians, and public health experts do dedicate years of their lives to study and service, often at great personal cost. But that commitment exists within a system that isn’t immune to bias, hierarchy, or self-interest. Career advancement, funding pressures, and institutional politics all shape which questions get asked and which answers are rewarded. Disagreeing with a superior, challenging an entrenched idea, or questioning a flawed consensus can easily end a career. It’s a structure that confuses authority with truth. Trust in science should never mean blind trust in scientists and their institutions. It should mean trusting a process — open data, transparency, debate, and reproducibility — that keeps science accountable to the public it serves.
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Jason Locasale retweeted
MIT is a far cry from the nerdy enclave that many of us alumni remember from the ’90s and ’00s. The culture that once prized curiosity and rigor has given way to activism and identity politics.
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Jason Locasale retweeted
BREAKING: MIT officially rejects the Trump administration’s Compact for Academic Excellence I received this alumni email. It is a masterclass in prevarication from President Sally Kornbluth. In the life sciences, where I’m most familiar, hiring over the past decade have increasingly reflected ideology and activism rather than scientific excellence. Meanwhile, many of the Institute’s most accomplished scientists have been forced out, pushed aside or marginalized. The claim that MIT “freely chooses these values because they’re right” is deeply cynical for an institution that long ago abandoned merit as its organizing principle. When accountability arrives, administrators suddenly rediscover “independence” and “academic freedom” - ideals they’ve spent years subordinating to politics and depriving their own faculty and students of.
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Join our Weaponization of Science Round Table Flaws and Fraud in Biomedical Research Tuesday, October 21st, 2025 from 12:00 - 5:00PM EST in Washington D.C. Click here to register: mahainstitute.us/science Panelists include @thackerpd @bigfatsurprise @LocasaleLab @ChrisMasterjohn @MaryanneDemasi, Mark Skidmore and more!
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Duke Lacrosse, especially the accuser's admission that she did, in fact, lie, really blows open the entire kangaroo court "process" we have in place for allegations of sexual assault on campuses—wrote this for @WashTimesOpEd via @IWF last year:
In the Duke lacrosse scandal, the accuser later went to prison, the DA was disbarred for misconduct - but the Duke administrator at the center was promoted, her role downplayed despite serious allegations in the players’ lawsuit. She went on to have a thriving career at Duke and a glorious retirement years later. That’s accountability in universities.
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Jason Locasale retweeted
Shocking that @MIT Broad fired someone for cheering Kirk’s murder, yet for 2 years MIT supported students and faculty cheering on mass murder. Threats, harassment, and calls for violence were ignored, & victims were left unprotected. Now they act, not bc of free speech or safety, but image & financial interests
The individual who posted a deeply offensive comment referencing the murder of Charlie Kirk is no longer employed at Broad Institute. We condemn the statement and have taken immediate action. There is no place in any institution, nor in our society, for statements such as this.
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Jason Locasale retweeted
Replying to @LocasaleLab
the logic: You are a reprehensible person who wants universities to get their act together so society benefits from funding them. 🤔
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In 2022, @alananewhouse wrote for @tabletmag, in a piece titled “Brokenism,” that “[t]he real debate today isn’t between the left and right. It’s between those invested in our current institutions, and those who want to build anew.” Inability to understand the terms of this debate is why many anti-RFK types, such as the writers of this WSJ piece, are confused about how a seemingly incogruent MAHA movement can make sense—they still don’t get why public trust is undermined as much as it is when CDC center directors sign off with their pronouns, or say things like “pregnant people,” or flaunt that they do BDSM satanism in their downtime (not even having the decency to keep it on the down low). Lots of anger that MAHA is burning this apparatus down, not considering that the apparatus halfway self-immolated and MAHA is just finishing the job.
This quoted post is unavailable.
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Jason Locasale retweeted
The criticisms of the "study" by Judith Kleinfeld are damning web.archive.org/web/20000816… I enumerate them here: 1. The committee was dominated by senior women, including the chief complainant (Nancy Hopkins), who acted as both judges and beneficiaries of the findings (e.g., gaining personal benefits like increased salaries or resources). This compromised objectivity, as interested parties controlled the process without male participation. 2. The report provides no quantitative or rigorous qualitative data to support claims of gender discrimination in areas like laboratory space, salary, research funds, or other resources. Disparities are asserted to be caused by discrimination, but no evidence was provided to substantiate these assertions. 3. MIT kept supporting facts confidential, citing privacy needs (e.g., on lab space differences), which violated scientific transparency and prevented external verification or replication. 4. Broad claims of "universal" discrimination are based on subjective perceptions from a small group of senior women in only three of six departments. Such claims ignored that junior women did not report similar issues. 5. Perceptions were not measured, counted, or analyzed per social science norms (e.g., no details on question wording, response tables, or coding of interviews). These perceptions were therefore blanket assertions that did not meet even the most basic scientific standards. 6. Senior women's self-descriptions as "exceptional pioneers" above average MIT faculty are contradicted by independent analyses, e.g., Guyot's data showing similar or lower prestige metrics for women compared to men. 7. An anonymous source close to the committee admitted that no actual evidence of gender discrimination was discovered, despite efforts to find it. 8. The report mixes generational data (current perceptions of junior vs. senior women) with unproven assumptions about future changes, leading to flawed conclusions about how experiences evolve over time, i.e., that junior women would come to perceive alleged discrimination later in their careers. 9. Substantive reports were not written without consulting all tenured women faculty, but male faculty were excluded from similar involvement, introducing additional bias. 10. Potential non-discriminatory factors like differences in seniority, productivity, or other variables were not addressed or controlled for in analyzing resource or salary differences. 11. The report's use of low numbers of women faculty (e.g., 8-10%) as evidence of bias is insufficient, as this could result from broader issues like women's career choices, lower interest in science, or pipeline shortages rather than discrimination at MIT. 12. The report's conclusions dovetailed with popular political agendas, suggesting that the ready acceptance of such low scientific standards was politically motivated.
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Matthew is missing piles of facts. Alas many of them are not public. Hopkins represented some women. Not all. Pleas by the unrepresented women to have an outside independent assessment were ignored. So. Here we are.
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Jason Locasale retweeted
The proposed formation of a “Merit and Civil Rights Committee” at Duke University, tasked with reviewing discriminatory practices in its medical school, is a necessary and welcome first step. The documented pattern of institutionalized preferences based on race and ideology at Duke's medical school raises serious questions about the integrity of its leadership and its commitment to genuine academic and medical excellence. However, for such a committee to be effective, it must be insulated from the very administrative machinery that enabled the discriminatory policies in the first place. Any reform process that involves current senior administrators—particularly those closely aligned with Dean Mary Klotman or involved in crafting or defending the contested practices—risks being little more than a performative gesture. Self-investigation by conflicted actors has no credibility, particularly in institutions where dissent is quietly punished and reputation management routinely trumps accountability. If this initiative is to restore trust and ensure legal and ethical compliance, then the committee must be composed of individuals with demonstrated records of merit, independence, and integrity—faculty and leadership figures who are respected for their scholarship and patient care, not for their proximity to institutional power. Anything less would reinforce the perception that Duke intends to protect its bureaucracy rather than reform it. True reform cannot come from within the system that allowed the rot to fester. It requires external oversight, clear standards, and a genuine recommitment to the values of equal opportunity, scientific excellence, and institutional transparency.
Blatantly discriminatory practices that are illegal have become all too common in our educational institution. Today, @SecKennedy and I sent Duke a letter insisting it restore merit and lawfulness on campus, and launched investigations into their conduct.
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Replying to @LocasaleLab
This, in a nutshell, is bureauism. Benefitting the apparatuses (apparati for the purists) becomes the objective of action instead of finding a solution to a problem. Essentially, problems create the need for more bureaucracy, and bureaucrats are only too eager to increase their power by creating new problems and existing problems larger. Building the power pyramid becomes more important than any function it is supposed to perform. So anything that enlarges it is welcomed. Now THAT is a sick system. To counteract this unfortunately tendency toward bureaucratic bloat, incentives should be given for problem solution without increasing administration size, and failure to do so penalized.
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