Great paper that dissects the genetics of kidney function by combining GWAS results with data from single cell ATAC sequencing of kidney tissue. The authors make a strong case for the majority of the heritability of polygenic traits come from a small portion of disease-relevant regions in the genome and not from all over the genome. Using LD score heritability enrichment analysis, the authors show that - 63% of the SNP heritability of kidney function comes from cis regulatory elements related to kidney tubular epithelial cells (56%) and podocytes (7%), which together represent mere 5.4% of the genome - 10% come from coding regions containing genes well implicated in kidney function, either through Mendelian diseases or mouse knockout studies, which represent mere 1.4% of the genome - and the rest 27% of SNP heritability come from the remaining 93% of the genome. Loeb et al. Nat Gen nature.com/articles/s41588-0…