@longlabstanford

Affiliated with @StanfordPath and @Stanford_ChemH. We study mammalian energy metabolism!

 Palo Alto, CA
longlabstanford.org
Joined February 2018
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  • Followers3.5K
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A pretty interesting experiment - engineering a metabolic bypass of mitochondria pyruvate uptake. Good to see that the expected cellular effects match w what would be generally expected from such a system
Nature Chemical Biology@nchembioOct 26
Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells nature.com/articles/s41589-0…

Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells

Nature Chemical Biology - The chemogenetic tool Grubraw activates mitochondria by generating pyruvate in the mitochondrial matrix. This triggers a genetic switch that slows down tumor cell...

nature.com
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A big thank you to Leslie Leinwand lab for hosting @Shuke_Xiao @ssiipei this week @CUBoulder. Learning more about 🐍 husbandry to get our own colony up and going @Stanford_ChEMH
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Delighted to spend today with the amazing Team FEAST and @rushika_perera @Stanford @UCSF- dissecting the effects of diet, obesity, and GLP1 medicines in pancreatic cancer. @SCIDirector @Ashworth_SF
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Our work deorphanizing MCT6 as the missing gut Lac-Phe transporter is out today @CellCellPress: local gut lactate metabolism influences gut-brain crosstalk, and also explains metformin’s effects on body weight. Congratulations to @Shuke_Xiao @alanshtung! cell.com/cell/fulltext/S0092…

MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss

The orphan transporter MCT6 is the route by which the meal- and exercise-associated metabolite Lac-Phe exits intestinal cells and enters the blood. Mice lacking gut MCT6 cannot maintain normal...

cell.com
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Selfie @Stanford_ChEMH
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Bertozzi alum…. Wow!🤯 @Stanford_ChEMH
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Now kicking off CRB60 is co-organizer @basktastic highlighting what I also agree is one of Carolyn’s most important contribution to science- her impact as a mentor and advisor @Stanford_ChEMH @Stanford
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So excited for today CRB60 symposium, 350+ alumni friends and colleagues here @Stanford_ChEMH @Stanford to celebrate Carolyn
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Lac-Phe is an exercise💪 and metformin💊 inducible blood-borne metabolite that suppresses appetite. How does Lac-Phe get into circulation? New from @Shuke_Xiao: a transporter deorphanization story that links local cellular metabolism to systemic activity: biorxiv.org/content/10.64898…

MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss

Metabolites are increasingly recognized as circulating molecules that regulate physiology, yet the mechanisms that couple intracellular production to organism-wide action remain poorly defined. Using...

biorxiv.org
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Join us for the CRB60 Symposium, celebrating our director Carolyn Bertozzi's legacy and impact on chemical biology, with talks from her lab alumni! Oct 9, 2026, Paul Berg Auditorium, Stanford. Register here: brnw.ch/21x64tQ @UCB_Chemistry
Speakers: Nicholas Agard • Genentech Steven Banik • Stanford Michael Boyce • Duke Xing Chen • Peking University Penelope Drake • 16 Waves Danielle Dube • Bowdoin Ryan Flynn • Harvard Zev Gartner • UCSF Howard Hang • Scripps Matt Hangauer • UC San Diego Ramesh Jasti • Oregon Jennifer Kohler • UTSW Jessica Kramer • Utah Lara Mahal • Alberta Stacy Malaker • Yale Lisa Marcaurelle • GSK Matthew Pratt • USC Jennifer Prescher • UCI Benjamin Schumann • TU Dresden Sloan Siegrist • UMass Amherst Ellen Sletten • Dartmouth David Vocadlo • Simon Fraser Christina Woo • Harvard Peng Wu • Scripps

ALT Speakers: Nicholas Agard • Genentech Steven Banik • Stanford Michael Boyce • Duke Xing Chen • Peking University Penelope Drake • 16 Waves Danielle Dube • Bowdoin Ryan Flynn • Harvard Zev Gartner • UCSF Howard Hang • Scripps Matt Hangauer • UC San Diego Ramesh Jasti • Oregon Jennifer Kohler • UTSW Jessica Kramer • Utah Lara Mahal • Alberta Stacy Malaker • Yale Lisa Marcaurelle • GSK Matthew Pratt • USC Jennifer Prescher • UCI Benjamin Schumann • TU Dresden Sloan Siegrist • UMass Amherst Ellen Sletten • Dartmouth David Vocadlo • Simon Fraser Christina Woo • Harvard Peng Wu • Scripps

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A very interesting concept... would love for all papers to be more interactive- and more standardized (!) along the way
James Zou@james_y_zouSep 16
Thrilled that #paper2agent is published in @nature today! Scientific knowledge is traditionally stored in passive papers. Paper2Agent transforms papers into virtual authors that answer questions, apply its methods and collaborate w/ other paper agents to make new discoveries 🧵
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BAMM 2026 group photo
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Another year, another BAMM! @SvenssonLab @StanfordPath @StanfordDRC Looking forward to a full day of great talks 💪💪 @ishahjain @rushika_perera @RobertoZoncu @MaayanLevyPhD
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Had a fun time chatting about peptides and pythons with Australia’s @DavidWoiwod and Monique. Live from the @sunriseon7 Melbourne studio- full interview here: youtu.be/1O_0DJHiGxo?is=aAYi…
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Alumni @LabSpiegelman celebrities
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Speaking now @AUDiabetesSoc, @SvenssonLab presents the latest on her lab’s work in new peptide discovery @StanfordMed @StanfordPath
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A remarkably fast timeline: 2022: our lab @veronical1411 first discovers Lac-Phe as an exercise-inducible anorexigenic metabolite 2024: @Shuke_Xiao @lynchielydia Lac-Phe also mediates metformin-associated weight loss 2026: an oral Lac-Phe mimetic in human completes phase 1 trial
Enveda
@envedaAug 18
Read more in @statnews's coverage about ENV-308, our second clinical-stage molecule to clear Phase 1 and the first drug ever tested in humans designed to harness the effects of exercise: statnews.com/2026/08/18/enve… #Enveda #ExercisePill #LearningFromLife #PRISM
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Reporting out today- Phase 1 clinical data, oral Lac-Phe mimetic ENV-308 from @enveda. No safety signals (good) and some changes in other biomarkers including leptin (!)… Phase 2 trials planned in for weight maintenance. @statnews statnews.com/2026/08/18/enve…

A pill that mimics exercise? Early results on drug designed to maintain both weight loss and muscle...

Colorado biotech Enveda reports preliminary results on a drug to help people maintain weight loss after GLP-1 use. Just don't call it exercise in a pill.

statnews.com
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Our collaborative effort to develop tools for mapping the secretomes of rare cell types in complex tissues is now out @CellRepMethods @longlabstanford @JayarajRajagop2. Congratulations @GShipkovenska @LyuXuchao cell.com/cell-reports-method…

A sensitive method for profiling cell-type-specific secretomes of rare cells from complex tissues

Shipkovenska et al. present an improved method for profiling cell-type-specific secretomes in complex tissues without the use of viral vectors. The authors perform proof-of-principle validation by...

cell.com
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Peptides peptides peptides… Seems like everybody wants to inject something these days. But what is the state of the science? @SvenssonLab and I share our thoughts in this article from Rachel Tompa @StanfordMed @StanfordPath @Stanford_ChEMH med.stanford.edu/news/insigh…

Peptides talk is everywhere: But what does the science say?

Stanford Health Care delivers the highest levels of care and compassion. SHC treats cancer, heart disease, brain disorders, primary care issues, and many more.

med.stanford.edu
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