Luke Presberg (@LukePresberg) header
Luke Presberg (@LukePresberg) profile picture
United States
Joined March 2017
Today, we're excited to share our work on agents for drug repurposing. In 2019, a diabetes drug (dapagliflozin) turned out to keep heart failure patients alive, and our biomedical research agents recovered it from first principles.
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Out of the box, long-horizon agents struggle to accurately perform end to end work in the real economy (outside of coding) because those tasks are not easily verifiable, the data is hard to scale, and going from inputs to real outcomes can actually take many days. Even if you had a reliable way to verify outcomes at scale (and weren’t bothered by the multi-hour iteration loops), the sheer volume of decisions by the agent that occur in a multi-hour job makes it hard to know whether performing well will generalize to production. Over the last two years at @trybasis, we've been solving this problem by supervising the process our agents take to get to outcomes, rather than just looking at whether the outcome itself is correct. We think this is the key to building production agents at scale. It's what has allowed us to run agents in production that operate for hours, sometimes days, and reliably perform tasks like entire complex tax returns end to end. Today, alongside @braintrust, we're open sourcing a standard for defining, evaluating, and eventually rewarding agent behaviors. Thread below with all the details on how we’re scaling behaviors to close the loop for long-horizon agents.
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Luke Presberg retweeted
Memory Store (@memorydotstore) gives your team and AI agents a shared company brain. Your team's knowledge & decisions are scattered across slack, emails, and people's heads. Memory Store turns them into a living wiki for your agents and teammates. Congrats on the launch, @ishitajindal17 & @diwanksingh! ycombinator.com/launches/QPs…
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Luke Presberg retweeted
We’re excited to launch the Codex app, a command center for building with agents. It gives you a focused space to manage multiple agents at once, run work in parallel, and collaborate with agents over long-running tasks. openai.com/codex
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Luke Presberg retweeted
we're excited about our continued collaboration with @cline on pushing real-world coding performance on their harness. cline-bench is a great example of how open, real-world benchmarks can move the whole ecosystem forward. high-quality, verified coding tasks grounded in actual developer workflows are exactly what we need to meaningfully measure frontier models, uncover failure modes, and push the state of the art. congrats @pashmerepat and team! we're also excited about the open call for contributions and the use of shared standards like harbor, which make it easier for the community to compare, improve, and ultimately build more capable coding agents together. huge thanks to @lukepresberg, Carter Mcclellan, and @bfioca on the openai team for continuing to help make cline successful.
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Luke Presberg retweeted
🏆 @OpenAI's GPT 5.1 sets a new state-of-the art on our Finance Agent Benchmark, beating out Sonnet 4.5 (Thinking) by 0.6%. (1/3)
Replying to @deanwball
better to do it that way than the alternative i have learned :)
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We got feedback on GPT‑5.1 from a handful of companies and developers. Here are their early impressions:
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🆕It's @openai o3-pro launch day! our high taste guest tester @benhylak has been previewing for the past week and found an interesting pattern: (link in reply) o3-pro doesn't noticeably outperform in normal situations, but it's just really, really, REALLY good at consuming ALL your context and using adroitly tools to get EVEN more context. o3-pro is a superlatively much better tuned agentic model than we've ever seen (yes, more than 4 Opus and 2.5 Pro, really — not just "big model smell" but flexing true agentic capability).
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Luke Presberg retweeted
We've been testing o3 & o4-mini for the last couple weeks and their reasoning is a genuine step up for accounting workflows based on our initial evals. Excited to start rolling these models out to our users over the next couple weeks.
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Luke Presberg retweeted
OpenAI wrote a great post on how they've partnered with us at @DecagonAI to ship performant and accurate AI agents! This post dives into some of the cool engineering challenges we solved. So many creative ways to use LLMs! openai.com/index/decagon/
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Luke Presberg retweeted
Thinking of building a fintech company? The @Stripe Issuing and Treasury team interviewed four fintech companies and put together a guide on best practices: stripe.com/en-ca/guides/buil…
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We had a blast this week—thanks for having us, @fintechdevcon! #fintechdevcon #StripeDev
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Luke Presberg retweeted
I love seeing fellow @ycombinator alums succeed on @stripe, *especially* during an economic slowdown Let’s look at two YC startups, @join_arc and AtoB (atob.com), that are growing rapidly and building their embedded finance products with Stripe BaaS 👇🧵
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Luke Presberg retweeted
Vox, among the most anti-technology publications now Starlink is opening up the world to access to the Internet, connecting billions and making more of the planet connected, but the sky NIMBYs are upset
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I just found the best use for hand tracking on Oculus Quest.
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Luke Presberg retweeted
I'm always surprised how much more small teams can get done than big teams.
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