G protein signaling. GPCRs. Protein structure & Biochemistry. CryoEM.
Rochester, NY
Joined February 2019
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Makaía Papasergi-Scott retweeted
The Western New York Structural Biology Collaborative Summer Symposium is July 28th in Rochester NY - It includes scientific talks, poster sessions, networking opportunities & exhibitor tables - Learn more zurl.co/JWnvr We are sponsoring & exhibiting at the symposium
Makaía Papasergi-Scott retweeted
The Western New York Structural Biology Collaborative Summer Symposium is July 28th in Rochester NY - It includes scientific talks, poster sessions, networking opportunities & exhibitor tables - Learn more zurl.co/JWnvr We are sponsoring & exhibiting at the symposium
Makaía Papasergi-Scott retweeted
Send in your research to this special collection covering key areas of GPCR research. The collection will include original research articles and a limited number of commentaries and consideration for minireviews: ow.ly/pIoq50Z6jYg
Makaía Papasergi-Scott retweeted
Now online in @NatureSMB - We combine AlphaFold, structural, and biochemical approaches to show that SMO directly inhibits PKA via a pseudosubstrate mechanism—revealing a new mode of #GPCR signal transduction in the #Hedgehog pathway. Big thanks to everyone who contributed!
New online! Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway dlvr.it/TSJMr4
Makaía Papasergi-Scott retweeted
Self-cleavage-dependent and -independent functions of Adgrg1/Gpr56 in mice | PNAS pnas.org/doi/10.1073/pnas.25…
Makaía Papasergi-Scott retweeted
🚨Job opening 🚨: In 2020, cumulatively 10,000 #cryoEM structures had been resolved. By 2025, 10,000 #cryoEM structures were determined within a single year. Join the international effort making all this data available. OneDep biocurator on the EMDB team: embl.wd103.myworkdayjobs.com…
Makaía Papasergi-Scott retweeted
The deadline has been extended to August 31 for Molecular Pharmacology's upcoming special collection, which celebrates the world-leading research showcased by attendees of the 5th Transatlantic ECI GPCR Symposium. Learn more: ow.ly/jaWS50Ywmeu
Makaía Papasergi-Scott retweeted
The new issue of #ScienceSignaling has arrived!
Research in mice shows how microglia can trigger depressive-like behaviors linked to neuroinflammation, in vitro work reveals that adhesion GPCRs aren’t activated by corticosteroids, and more. scim.ag/4tLz8WI
Makaía Papasergi-Scott retweeted
A mechanistic analysis of adhesion #GPCRs reveals that peptide mimics, but not the corticosteroid beclomethasone, can activate signaling downstream of the GPCR GPR97/ADGRG3 and trigger neutrophil shape changes and migration. @UMPharmacology @lab_tall scim.ag/4kNU77g
Makaía Papasergi-Scott retweeted
Register today!
We're excited to see your GPCR research 😄
Keynote lectures will be announced soon, so stay tuned! 👀
Makaía Papasergi-Scott retweeted
Excited to share our latest preprint! We used cryoEM and MD simulations to look at the GTP-induced activation of the mu-opioid receptor-Gi complex with partial, full, & super agonists resolving Gi activation and how its modulated by different ligands!
biorxiv.org/content/10.1101/…
Makaía Papasergi-Scott retweeted
Excited to present our preprint on the structure-function relationship of anaphylatoxin complement receptors. A casual number of 19 structures deciphering ligand recognition mechanisms, G protein/arrestin and species specific signaling. Check it out! biorxiv.org/content/biorxiv/…
Makaía Papasergi-Scott retweeted
Our GzESTY paper is online. We optimized a cell based assay to sensitively detect GPCR activation in response to ligand application or in complex mixtures containing endogenous ligands. GzESTY was designed to aid in GPCR deorphanization efforts.
nature.com/articles/s41467-0… – at Brighton, NY
Makaía Papasergi-Scott retweeted
Maybe the most amazing microscope paper of the year just dropped: Live 4pi-SIM (a.k.a I5S*):
nature.com/articles/s41592-0…
Having worked with Mats Gustafsson, I can attest that this is both extremely hard, but also extremely cool!
Kudos to the authors!
*cell.com/AJHG/fulltext/S0006…
Makaía Papasergi-Scott retweeted
Introducing a new class of potent opioid analgesics that remain in the periphery (hence no respiratory depression) and can be locally activated with light (hence no constipation). As efficacy switches, they also provide insight into how opioids can switch from weak to strong agonists! Great collab with Seva Katritch, Cornelius Gati, and Josh Levitz.
biorxiv.org/content/10.1101/…
Makaía Papasergi-Scott retweeted
How proximal is proximity labeling❓ Using DNA nanorulers we found that TurboID/BioID are largely contact labeling, while APEX2 also bears a major contact labeling pathway in parallel with diffusive labeling.
biorxiv.org/content/10.1101/…
Special thanks to Alice Ting for discussions!
Makaía Papasergi-Scott retweeted
Conformational plasticity of human acid-sensing ion channel 1a | bioRxiv
biorxiv.org/content/10.1101/…
Makaía Papasergi-Scott retweeted
1/6 🧵 I'm building what might be the smallest
#opensource #spectrometer with an easy to use UI! I call it a pocket spectrometer. Combining #M5StickC(~$20) with #AS7341 sensor (~$16). My goal? A complete spectrometer that is barely larger than a sample cuvette itself.
Makaía Papasergi-Scott retweeted
I would appreciate community guidance on building out research computing resources from scratch. Rather than building/maintaining compute clusters, what are the best cloud-based, university-level research computing options? I have my experiences, but I want to hear from others.
Makaía Papasergi-Scott retweeted
New job posting: Assistant Professor - Boston University Chobanian & Avedisian School of Medicine - Boston, MA dlvr.it/TD3zJ3 #ASBMBCareers
