Marcus Bage (@Marcus_Bage) header
Marcus Bage (@Marcus_Bage) profile picture

Marcus Bage

@Marcus_Bage

Bioinformatician @PDBEurope. Standardising and enriching protein modification data in structure models.

 Cambridge, UK
Joined September 2012
  • Tweets39
  • Following93
  • Followers49
The PCM and PTM remediation has started and we are so hyped! ⬇️ Read more ⬇️ wwpdb.org/news/news?year=202…
Image from Protein Data Bank (@PDBeurope)
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Really glad to see our work published in @Nature @CommsBio: nature.com/articles/s42003-0…. This analysis of 39 fragment screening experiments sets the scene for our future work on function prediction for ligand sites across the @PDBeurope. @gjbarton @bartongrp @stuartmac44 @CallumMIves
Image from Dr Javier Sánchez Utgés @javierutges.bsky.social (@JavierUtges)
Geoff Barton (@gjbarton) profile pictureGeoff Barton@gjbarton25 Jul 2023
Our new paper: "Classification of likely functional state for ligand binding sites identified from fragment screening" by @JavierUtges @CallumMIves @stuartmac44 now available as a preprint - poster at #ISMBECCB2023 on the next step in this work: doi.org/10.21203/rs.3.rs-318…
Image from Geoff Barton (@gjbarton)
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Maxim Tsenkov: curating the biological functions of proteins using the AlphaFold Protein Structure Database
Image from IBDC (Indian Biological Data Centre) (@ibdctweets)
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Are you a front-end developer interested in biological data? We have a post available for development of user-facing web pages for displaying molecular structures & annotations. 📅Deadline: 19 March 2024. For more information and to apply: 🔗embl.org/jobs/position/EBI02…
Image from Protein Data Bank (@PDBeurope)
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In our newest practical guide, developed with @GoogleDeepMind and @emblebi, delve into the fundamentals of #AlphaFold, explore its strengths and limitations, and gain practical skills through hands-on exercises. Start the free, self-paced tutorial today: ebi.ac.uk/training/online/co…
Online tutorial. AlphaFold: a practical guide. Co-developed by Google DeepMind and EMBL's European Bioinformatics Insitute (EMBL-EBI).

ALT Online tutorial. AlphaFold: a practical guide. Co-developed by Google DeepMind and EMBL's European Bioinformatics Insitute (EMBL-EBI).

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Excited to join @aibc2024! Visit our poster today, chat with @deeptigupta19 and @PDBeurope team. Grab some awesome #PDBe stickers and #PDBart calendars to take home. Don't miss out! See you there! 🧬🔬@gobalbiodata #AIBC #BiocurationConference @unescorb #Datascience
Image from Protein Data Bank (@PDBeurope)
Image from Protein Data Bank (@PDBeurope)
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Celebrating Sunday's #WorldWildlifeDay, we’re highlighting a key player in stress response: the glucocorticoid hormone ➡️ managing stress & inspiring art... #PDBart More: 🔗 article: ebi.ac.uk/pdbe/news/molecula… 🔗 protein structure: pdbe.org/7d77
Image from Protein Data Bank (@PDBeurope)
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A great start to #AIBC2024, with a workshop exploring #glycosylation, #biocuration and the dissemination of biological data, held by @gly_gen, @CfdeNih and @aibc2024. I'm looking forward to all the discussions that come out of the next few days.
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Thrilled to join #AIBC @aibc2024 with @Marcus_Bage and @mitsenkov representing @PDBe and #AlphaFold DB, diving into the world of #biocuration. Anticipating inspiring opportunities at this global biocuration meet @PDBe @wwpdb #AlphaFold @globalbiodata @unescorcb #DataScience 🌍✨
Image from Deepti Gupta (@deeptigupta19)
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Marcus Bage retweeted
Maxim Tsenkov (@mitsenkov) profile picture
Maxim Tsenkov@mitsenkov5 Mar 2024
Thrilled to be at #AIBC2024, for a fantastic gathering of @biocurator experts. Here with @PDBeurope to showcase use cases with #AlphaFold DB and highlight its utility in the #biocuration field. Eager to learn from you, so let’s connect and discuss! @unescorcb @globalbiodata
Image from Maxim Tsenkov (@mitsenkov)
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In October 2023, wwPDB will roll out updated CCD data files with additional annotation and standardized atom naming of peptide residues. Find out more about these changes and how they will affect you: wwpdb.org/news/news?year=202…
Image from Protein Data Bank (@PDBeurope)
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When hexokinase phosphorylates six-carbon sugars, it toggles between conformational states. The #PDBeKB’s new #Alphafold superposition tool suggests the predicted model adopts the sugar-bound conformation. See how the new tool can help your research! 🔗ebi.ac.uk/pdbe/pdbe-kb/prote…
Image from Protein Data Bank (@PDBeurope)
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Our work from @UZDundee group on PorB is now available in @BBAjournals! This interdisciplinary collaboration utilises X-ray crystallography, electrophysiology & MD simulations to study porin-based drug-resistance in Gram-negative bacteria @UoDLifeSciences sciencedirect.com/science/ar…
Image from Callum Ives (@CallumMIves)
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Marcus Bage retweeted
GRE Dundee (@GREDundee) profile picture
GRE Dundee@GREDundee16 Mar 2021
Latest collaborative research from @AndreiPisliakov & @Vichaico has identified novel interaction sites on the mRNA Capping Enzyme that are essential for its activity. Work published in @NAR_Open with @Marcus_Bage first author 👏 buff.ly/3bS2Gfu
Image from GRE Dundee (@GREDundee)
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Latest collaborative research from @AndreiPisliakov & @Vichaico has identified novel interaction sites on the mRNA Capping Enzyme that are essential for its activity. Work published in @NAR_Open with @Marcus_Bage first author 👏 buff.ly/30U0ihD
Andrei Pisliakov (@AndreiPisliakov) profile pictureAndrei Pisliakov@AndreiPisliakov11 Mar 2021
Our new paper on regulation of RNA Capping Enzyme by CTD of #RNA #Polymerase II is out in Nucleic Acids Research! Excellent work by PhD student @Marcus_Bage and great collaboration with Vicky Cowling’s lab @Vichaico. biomolecular simulations; allostery academic.oup.com/nar/advance…
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🔓 #OpenAccess A novel RNA Pol II CTD interaction site on the mRNA Capping Enzyme is essential for its allosteric activation ➡️buff.ly/3tqGMWx @UoDSciEng @UoDLifeSciences @GREDundee @Marcus_Bage Dr Almohammed @Vichaico @AndreiPisliakov #RNA #Polymerase II
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Our new paper on regulation of RNA Capping Enzyme by CTD of #RNA #Polymerase II is out in Nucleic Acids Research! Excellent work by PhD student @Marcus_Bage and great collaboration with Vicky Cowling’s lab @Vichaico. biomolecular simulations; allostery academic.oup.com/nar/advance…
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Delighted to see my first first author paper online today! We use simulations to find RNA PolII CTD binding sites on the mRNA Capping Enzyme and uncover their vital role in allosteric activation. Of interest to anyone using MD to study PPIs and allostery! academic.oup.com/nar/advance…
A novel RNA pol II CTD interaction site on the mRNA capping enzyme is essential for its allosteric...

A novel RNA pol II CTD interaction site on the mRNA capping enzyme is essential for its allosteric...

Abstract. Recruitment of the mRNA capping enzyme (CE/RNGTT) to the site of transcription is essential for the formation of the 5′ mRNA cap, which in turn e

academic.oup.com
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A huge thank you to everyone involved in the work @AndreiPisliakov @Vichaico and Rajaei.
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We combined simulations with biochem validations to provide insights into mRNA Capping Enzyme recruitment and activation, improving our understanding of regulation of gene expression. Excellent work by @Marcus_Bage and a great collaboration with @Vichaico. biorxiv.org/content/10.1101/…
Identification of novel RNA Polymerase II CTD interaction sites on the mRNA Capping Enzyme

Identification of novel RNA Polymerase II CTD interaction sites on the mRNA Capping Enzyme

Recruitment of the mRNA Capping Enzyme (CE/RNGTT) to the site of transcription is essential for the formation of the 5’ mRNA cap, which in turn ensures efficient transcription, splicing, polyadenyl...

biorxiv.org
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