Biostatistician in The Division of Genetics and Epidemiology at @ICR_London ORCID: https://xitter.gq/t.co/Uji4eswv8s
Joined January 2021
- Tweets35
- Following137
- Followers45
- Likes43
Mark Brook retweeted
Family History of Prostate Cancer and Survival Outcomes in the UK Genetic Prostate Cancer Study
buff.ly/3jcAERZ
@HolsUroLols @zx8754 @kotezsofi
Mark Brook retweeted
Excited to see this work published! In a large sample of >22K African ancestry men, we show that a rare #HOXB13 variant found only in men of West African ancestry is associated with 2.4-fold higher risk of overall #prostatecancer and 5.1-fold higher risk of metastatic disease.
A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry buff.ly/3I2YyGw
@BurcuDarst et al.
"HOXB13 X285K was associated with 2.4-fold increased odds of PCa (95% CI 1.5-3.9), with greater risk for more aggressive/advanced disease"
Mark Brook retweeted
Very sad that Hon Fellow of @BritishAcademy_ Sir David Cox has died. He was a towering figure in the field of statistics. I remember getting him to do one of the @RoyalStatSoc 180th anniversary lectures in 2014 when he was 90 and still on fine form youtu.be/xRik3vOKLcU
Mark Brook retweeted
Our manuscript on the evaluation of associations of BRCA1 and BRCA2 mutations with 22 different cancers (other than breast/ovarian cancers in women) out @JCO_ASCO. Analysed Data from >5000 families with mutations from CIMBA
@oncoalert #gcchat @CRUK_CI
ascopubs.org/doi/abs/10.1200…
Mark Brook retweeted
Results of the first screening round of the IMPACT study for men with mismatch repair genes pathogenic variants.
Read more 👇
prostate.uroonco.uroweb.org/…
#prostatecancer #Movember
@marcobrooko @judeoffman @SapnaSyngal @roodvdb
Mark Brook retweeted
"Our new findings show that PSA testing in men with #LynchSyndrome is much more likely to pick up life-threatening #ProstateCancer than in the general population." - Professor Rosalind Eeles, of the ICR and @royalmarsdenNHS.
Read more in @BBCNews.
bbc.co.uk/news/health-589524…
Mark Brook retweeted
The PROFILE study aims to understand why some men, including black men, are at greater risk of #ProstateCancer.
Winston, Richard, Frederick, and Olivier explain why more men should sign up 👇🏿👇🏼👇🏾
#BlackInCancerWeek21 @cancerBRC @royalmarsdenNHS @ProstateUK @realpaulparker2
Mark Brook retweeted
📢 The ICR's and @royalmarsdenNHS' PACE-B trial showed that using advanced radiotherapy called SBRT to deliver precise treatment over a short time frame in #ProstateCancer, didn't lead to worse side effects compared to standard #Radiotherapy 👇
icr.ac.uk/news-archive/short…
Mark Brook retweeted
An interesting tale of science communication, journalism and the culture wars has just dropped - 🧵
@JenniferRaff @ewanbirney @aylwyn_scally @minouye271 + I recently published a paper about the lexicon of genetics, and how it needs to be addressed
bit.ly/3ddQu96
Mark Brook retweeted
"Thanks to you, this study will help us understand more about the genetics of prostate cancer."
@realpaulparker2 is taking part in our groundbreaking PROFILE study to help us understand why black men are twice as likely to get prostate cancer.
Join him: bit.ly/2I4rJzt
Mark Brook retweeted
A group of us (@minouye271, @JenniferRaff, @aylwyn_scally @AdamRutherford and myself) have written a piece on the language we use in genetics; untangling from previous sometimes racist language and being more precise and less harmful. We welcome feedback. arxiv.org/abs/2106.10041
Mark Brook retweeted
Constructing and evaluating risk models in non-European ancestry populations is essential to broaden the impact of genomic medicine. Excited to be a part of this group @ChrisHaiman @johnwitte @GENES_PK and others supported by the consortium. @KECKSchool_USC @uscphs @USCBiostat
Research studies are starting to use polygenic risk scores to determine a person’s inherited risk for diseases. @NIH is awarding grants to develop methods that will improve how polygenic risk scores can be used to predict disease in diverse communities. bit.ly/3wednRj
Mark Brook retweeted
Looking forward to Stephen Chanock talking on “Radiation, genomic alterations in papillary thyroid carcinoma and transgenerational studies following the Chernobyl accident” @mrc_ieu online seminar 21st June 3pm UK time, all welcome bristol.ac.uk/integrative-ep…
Mark Brook retweeted
so excited to see this out. TWAS fails to implicate many risk regions as it focuses on steady-state expression levels. Enter CWAS, that uses chromatin variation to reveal context-dependent gene regulation as drivers of prostate cancer risk
biorxiv.org/content/10.1101/…
Mark Brook retweeted
Really nice editorial on our recent @EUplatinum publication describing the combined effect of rare and common variants in #ProstateCancer. Discusses the use of RPMs/PRS/fam hx for screening and next steps needed to evaluate the clinical utility of #PRS
europeanurology.com/article/…
Mark Brook retweeted
My thoughts on this piece, which lays out opportunities and challenges for improving cancer prevention and screening using polygenic risk models for cancer. I'm more optimistic than the authors. tl;dr Never say never; clinical utility is context-specific; more research needed.
Will polygenic risk scores (PRSs) for #cancer ever be #clinically useful?
Our (@clare__turnbull @HoulstonLab_ICR @ICR_London) commentary in @Nature_NPJ is out: nature.com/articles/s41698-0…
A thread:
1/n
Mark Brook retweeted
Combined Effect of a Polygenic Risk Score and Rare Genetic Variants on Prostate Cancer Risk
buff.ly/3b0dCqt
@BurcuDarst @dvconti @ChrisHaiman
Mark Brook retweeted
I've been very fortunate to have a number of good mentors throughout my career to date. Ahead of #InternationalWomensDay @ICR_CTSU director Judith Bliss and I spoke to @ICR_London about what mentoring means to us 👇
🎥 Mentorship is a nuanced process and no two mentorship journeys are the same. For #InternationalWomensDay, we spoke to @ICR_CTSU Director Prof. Judith Bliss & Senior Statistician @HollyTovey about their paths.
#MemorableMentors #WomeninSTEM
Full video: youtu.be/kTUUdaNizXA
Mark Brook retweeted
New paper examining rare variants in the DNA repair pathway and the risk of colorectal cancer. Uses integrated Bayesian Risk Index, a method to incorporate prior information @uscphs @USCBiostat @KeckMedUSC pubmed.ncbi.nlm.nih.gov/3362…
Mark Brook retweeted
Evaluating cross-cancer relationships of polygenic risk scores for 16 cancers in two large cohorts.
@RebeccaEGraff, @johnwitte, @LoriSakoda, @WitteLab, @KPDOR
nature.com/articles/s41467-0…