@pennmedicine Heme/Onc Fellow via @UCDmedicine; @thebianchilab; @mayoMN_imres
Philadelphia, PA
Joined July 2020
- Tweets1.5K
- Following923
- Followers19.5K
- Likes4.5K
Matthew Ho retweeted
#ICYMI: the long-awaited updated @ASH_hematology #ITP guidelines are here!
With so many new agents for managing ITP, I’m excited for these recs to better help our patients achieve durable platelet responses and improved QOL
Link: ashpublications.org/bloodadv…
Matthew Ho retweeted
We talk about bsAb revolution coming across the field of oncology - now more of it in classical hematology as well!
Letter in big @TheLancet: Time-limited teclistamab in dara-refractory ITP with basically instant platelet normalization 👏
#MMsb bsAbs to the rescue!
Matthew Ho retweeted
🧵A brief thread on #CardiovascularSurgery and #PCI approaches for patients with heparin-induced thrombocytopenia (HIT) 🩸
Happy to share our review on this topic was recently published: mp.pl/paim/issue/article/169…
#hemetwitter #hemesky #classicalhematology
*not covering aHIT
1/8
Matthew Ho retweeted
Check out our latest episode "The Aquila Study: Blowing Hot Air or a Soaring Success for Smoldering Multiple Myeloma" with @ManniMD1 @ajperissinotti and @Berninini 🦅💨 #myeloma #badblood creators.spotify.com/pod/sho…
Matthew Ho retweeted
Simple concept of GN. It’s all about location!
1. Subendothelial deposits/injury by Ig, immune-complexes, complement, other mechanism leads to influx of leukocytes= inflammation=GN
2. Subepithelial deposits/injury= protected by GBM & endothelial cells=no inflammation=No GN. 1/3
Matthew Ho retweeted
1/6
TPE-FREE MANAGEMENT OF IMMUNE TTP (iTTP)
Retrospective study from Austria and Germany
ADAMTS13 activity at baseline <10% in all patients
Treatment group (TPE-free): 42 acute iTTP episodes in 41 patients received TPE-free management with caplacizumab + steroids +/- Ritux
Matthew Ho retweeted
A comprehensive review in @BloodJournal on risk stratification/scoring in MPNs
ashpublications.org/blood/ar…
Matthew Ho retweeted
Here is our article that defines and disambiguates both #ockhamsrazor and #hickamsdictum for #differentialdiagnosis
link.springer.com/article/10…
And a blog post with additional information:
medicalevidenceblog.com/2024…
And tweetorial as promised
Matthew Ho retweeted
Our first RCT on using an LLM on diagnostic reasoning is out!
And the results are 🔥🌶️... adding ChatGPT did NOT improve diagnostic accuracy or reasoning, and the AI alone outperformed ALL the humans.
What does this mean? A 🧵⬇️
xitter.gq/EricTopol/status/18509…
A small randomized trial of generative #AI for diagnosis again (as seen in a few previous studies) shows higher performance for #AI than physicians + AI. May indicate that physicians need to be trained on how to incorporate AI.
jamanetwork.com/journals/jam…
Matthew Ho retweeted
1/ Challenge accepted. I have run a series of breast mammograms (x-rays), ultrasounds and MRIs through versions of GPT4 and posted the results here previously.
Even though it's data contamination to repost images I already used on X, it's an easy bench mark.
So how did Grok do on breast radiology? A little better than GPT4v, but not a single diagnosis correct.
👇
Matthew Ho retweeted
🆕 Infographic on Systemic Lupus Erythematosus!
• Recognize signs/symptoms of #lupus and when SLE should be on your DDx
• Learn what labs to send if you suspect SLE: And don’t forget to ☑️ UA/UPC ratio! 🫘
#RheumTwitter #MedX #MedTwitter #NephTwitter #Rheumatology
Matthew Ho retweeted
Pseudo-AKI - some drugs cause an increase in creatinine due to decreased creatinine secretion. Cystatin C will be normal. #KidneyWk
Matthew Ho retweeted
Hey #NeuroTwitter , check out my #neuromuscularbuckets. It's a method to work backward when evaluating patients with neuromuscular disorders.
Sometimes you know the patient has a peripheral nerve disorder, but you get stuck on where to go next. That's where the buckets are helpful. Prefilled buckets that localize to one of the six main aspects of the PNS can help you think of diseases/entities that you don't want to miss. If you have a clinical picture of those disease in your mind while thinking through the case, you'll check for certain things you may have otherwise skipped over!
A thread...
#medsocial30
@NDECinstitute Day 12
Matthew Ho retweeted
This looks great!
Here is our version of an approach to HLH/MAS — made with @nickmmark !
🆕OnePager on Hemophagocytic Lymphohistiocytosis (HLH) / Macrophage Activation Syndrome (MAS), created w/ @nickmmark
☔️ Cytokine Storm
🫁 Multi-Organ Failure
🌡️ Fever
🩸 Cytopenias/↑ Ferritin
🦠 Infection, Autoimmune, Cancer
#MedTwitter #FOAMed #RheumTwitter #HemeTwitter
Matthew Ho retweeted
1/
I once heard that a fever in the ICU was a "fever of too many origins."
Same can be said altered mental status/encephalopathy!
We put together a comprehensive approach to these challenging patients for #SeminarsinNeurology
A thread with our approach!
pubmed.ncbi.nlm.nih.gov/3913…
Matthew Ho retweeted
Attended on our medicine consult service for 1 day
Here are 5 teaching points that came up
#MedTwitter #FOAMed #HospitalMedicine #NewsYouCanUse
Matthew Ho retweeted
1. Which prophylaxis do you chose after a hip or knee surgery?
Simplistic: ASA=LMWH
Correct: ASA has similar mortality & PE as LMWH but 1-2% more uncomplicated DVTs
In people at very high VTE risk, may consider LMWH if convenience & cost not an issue
xitter.gq/AnilMakam/status/16161…
New @NEJM pragmatic trial says aspirin is same vs LMWH after fracture
Last summer a JAMA cluster RCT study said aspirin was worse after hip/knee replacement
In reality both say the same thing
LMWH has similar mortality but 1-2% less VTE within 90 days
nejm.org/doi/full/10.1056/NE…
Matthew Ho retweeted
On world #osteoporosis day, here is a quick recap for its screening & management
"say no to fragile bones" 🦴
cmaj.ca/content/195/39/E1333
#MedTwitter #RheumTwitter
Matthew Ho retweeted
I love these two slides on the evidence for combination therapy in persistent MRSA and MSSA bacteremia. References in footer of each slide. #IDWeek2024
