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Mugesh Lab

@MugeshLab_IISc

Chemical biology & bioinorganic chemistry research group @iiscbangalore: enz mimetics, nanozyme, halogen bond, UAA. Led by Prof. G. Mugesh. Student-run account.

 Bangalore, India
mugesh-iisc.in/
Joined May 2023
  • Tweets73
  • Following112
  • Followers489
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📜New Publication Alert! Delighted to share our latest publication in Angewandte Chemie International Edition: "Halogen Bonding as a Molecular Recognition Strategy for Genetic Code Expansion." doi.org/10.1002/anie.5508153 Congratulations to all authors! @mugeshg
Halogen Bonding as a Molecular Recognition Strategy for Genetic Code Expansion

Halogen Bonding as a Molecular Recognition Strategy for Genetic Code Expansion

Halogen bonding (XB) is used as a driving force to engineer tRNA synthetase variants that selectively charge 3,5-diiodo-l-tyrosine (DiIY) even in the presence of the closely related analogues...

onlinelibrary.wiley.com
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📜Delighted to share our latest review article in Chemical Society Reviews: "From Fenton reaction to ferroptosis: chemistry of metal complexes in regulated cell death by lipid peroxidation." doi.org/10.1039/d6cs00041j Congratulations to @mugeshg @Shivangiwatts @sharathbn_90
From Fenton reaction to ferroptosis: chemistry of metal complexes in regulated cell death by lipid...

From Fenton reaction to ferroptosis: chemistry of metal complexes in regulated cell death by lipid...

Ferroptosis is a regulated, iron-dependent form of cell death characterized by the unchecked peroxidation of polyunsaturated phospholipids and the collapse

pubs.rsc.org
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Thrilled to share our latest article in European Journal of Inorganic Chemistry, "Tuning Thiol Stability and Anticancer Activity in Benzimidazole-Derived Au(I)–NHC Complexes Through Chloride-to-Thiolate Ligand Exchange". Congratulations to the authors! doi.org/10.1002/ejic.70283
Tuning Thiol Stability and Anticancer Activity in Benzimidazole‐Derived Au(I)–NHC Complexes Through...

Tuning Thiol Stability and Anticancer Activity in Benzimidazole‐Derived Au(I)–NHC Complexes Through...

Benzimidazole-based Au(I)–NHC complexes were tuned via ligand design (Cl vs. SR) to control thiol reactivity and stability. While chlorido complexes undergo rapid thiol exchange, thiolates remain...

chemistry-europe.onlinelibrary.wiley.com
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Congratulations to Dr. Sagar Kumar for successfully defending his PhD thesis. We extend our sincere gratitude to Prof. Thimmaiah Govindaraju for chairing the defense.
Image from Mugesh Lab (@MugeshLab_IISc)
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📜Thrilled to share our latest work in ChemistryEurope: "Strain-Enabled Redox Chemistry of Naphthalene Peri-Dichalcogenides: Synthetic Strategies, Unusual Reactivity, Mechanistic Insights and Potential Applications." chemistry-europe.onlinelibra… Congratulations @Debasishgi @mugeshg !
Strain‐Enabled Redox Chemistry of Naphthalene Peri‐Dichalcogenides: Synthetic Strategies, Unusual...

Strain‐Enabled Redox Chemistry of Naphthalene Peri‐Dichalcogenides: Synthetic Strategies, Unusual...

Naphthalene peri-dichalcogenides exhibit unique strain-driven redox and catalytic behavior, enabling multi-electron transformations, and emerging applications in synthesis, materials, and biomedical...

chemistry-europe.onlinelibrary.wiley.com
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📜New Publication Alert! Thrilled to announce our latest article in Chemistry Europe: "Dual Redox Behavior of Mitochondria-Targeting Antioxidant: Prooxidant Activity Through Light-Induced Redox Active Triplet State." Congratulations to all authors! chemistry-europe.onlinelibra…
Dual Redox Behavior of Mitochondria‐Targeting Antioxidant: Prooxidant Activity Through Light‐Indu...

Dual Redox Behavior of Mitochondria‐Targeting Antioxidant: Prooxidant Activity Through Light‐Indu...

In mammalian cells, mitochondria targeting charge neutral molecule (compound 1) shows antioxidant properties in dark but becomes prooxidant in presence of visible light to induce apoptosis. Mechani...

chemistry-europe.onlinelibrary.wiley.com
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📜Thrilled to present our latest work in Inorganic Chemistry: "Ligand-Tuned Mn(I) Complexes with Oxazole, Thiazole, and Selenazole Scaffolds: Synthesis and Mechanistic Insights into Light-Driven CO Release." Congratulations @Pranali64528045 @mugeshg doi.org/10.1021/acs.inorgche…
Ligand-Tuned Mn(I) Complexes with Oxazole, Thiazole, and Selenazole Scaffolds: Synthesis and...

Ligand-Tuned Mn(I) Complexes with Oxazole, Thiazole, and Selenazole Scaffolds: Synthesis and...

Abstract. Photoactivated carbon monoxide-releasing molecules (photo-CORMs) enable spatiotemporal control of CO delivery with therapeutic potential. We repo

pubs.acs.org
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📜New Publication Alert! Thrilled to share our latest publication in Chemical Communications: A Single Heteroatom Controls Halogen-versus Chalcogen-Bond-Driven Cellular Uptake. pubs.rsc.org/en/Content/Arti… Congratulations to the authors! @mugeshg @Debasishgi @ekta22_
A single heteroatom controls halogen- versus chalcogen-bond-driven cellular uptake

A single heteroatom controls halogen- versus chalcogen-bond-driven cellular uptake

Halogen and chalcogen bonds can both promote membrane recognition and here we demonstrate that within the same scaffold, oxygen analogues exhibit halogen-d

pubs.rsc.org
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📜New Review Alert! Delighted to share our recent article in Angewandte Chemie: "p-Benzoyl-l-phenylalanine as a Multifunctional Noncanonical Amino Acid in Synthetic Biology: Photoprobing, Photocatalysis, and Structural Programming for Biocontainment." onlinelibrary.wiley.com/doi/…
p‐Benzoyl‐l‐phenylalanine as a Multifunctional Noncanonical Amino Acid in Synthetic Biology:...

p‐Benzoyl‐l‐phenylalanine as a Multifunctional Noncanonical Amino Acid in Synthetic Biology:...

p-Benzoyl-l-phenylalanine (pBzF) integrates genetic code expansion with benzophenone photochemistry to enable proximity-based labeling, programmable biocatalysis, and biosafe microbial engineering,...

onlinelibrary.wiley.com
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Congratulations to the authors!
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📜New Publication Alert Thrilled to share our latest publication in Chemistry-A European Journal: "Chalcogen-Substituted Molecular Rotors as Polarity and Viscosity Sensors for Amyloid-β Fibril Formation and Bioimaging." doi.org/10.1002/chem.2025031… Congratulations! @mugeshg @ekta22_
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🧑‍🔬New Publication Alert! Thrilled to share our recent publication in Angewandte Chemie International Edition: "From Phenols to Proteins: One-Pot Biosynthesis and Genetic Encoding of Chalcogen-Containing Tyrosine Analogues." doi.org/10.1002/anie.2025201…
From Phenols to Proteins: One‐Pot Biosynthesis and Genetic Encoding of Chalcogen‐Containing...

From Phenols to Proteins: One‐Pot Biosynthesis and Genetic Encoding of Chalcogen‐Containing...

A one-pot enzymatic platform enables the biosynthesis and site-specific incorporation of chalcogen-containing tyrosine analogues (O, S, Se) into proteins in E. coli. Engineered tyrosine phenol lyase...

onlinelibrary.wiley.com
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Congratulations to all authors! @mugeshg @Sandhya79751352 @kusajiraul @SATISHK48662537 @Kumar_Rahul_33
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📜New Publication Alert! Thrilled to share our recent work in Chemistry-An Asian Journal: Confined Micellar Environments Modulate Thiol Reactivity and Nitrite Release From 4-Nitronaphthalimide Nitric Oxide Prodrugs. Congratulations @mugeshg & @yahoosahoo! aces.onlinelibrary.wiley.com…
Confined Micellar Environments Modulate Thiol Reactivity and Nitrite Release From 4‐Nitronaphthal...

Confined Micellar Environments Modulate Thiol Reactivity and Nitrite Release From 4‐Nitronaphthal...

Cationic micelles act as confined nanoreactors that accelerate thiol-mediated nitrite release from 4-nitronaphthalimides. Surfactant-like derivatives achieve enhanced reactivity, offering a strategy...

aces.onlinelibrary.wiley.com
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Congratulations to Dr. Pranali Dhotre for successfully defending her PhD thesis. We extend our sincere gratitude to Prof. Prasenjit Ghosh for chairing the defense. @ghoshpras @Pranali64528045
Image from Mugesh Lab (@MugeshLab_IISc)
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Congratulations to Dr. Shivangi for successfully defending her PhD thesis. We extend our sincere gratitude to Prof. Jitendra Kumar Bera for chairing the defense. @Shivang82663285
Image from Mugesh Lab (@MugeshLab_IISc)
Image from Mugesh Lab (@MugeshLab_IISc)
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New Review Alert! Our latest article in Coordination Chemistry Reviews explores how non-covalent interactions shape the structure, stability, and reactivity of metalloenzymes. 🔗 Read here: doi.org/10.1016/j.ccr.2025.2…
Image from Mugesh Lab (@MugeshLab_IISc)
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Congratulations @mugeshg @Pranali64528045 and @Debasishgi !
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🧪 New Publication Alert! Thrilled to share our latest work in Chemistry – A European Journal: Glutathione-Triggered Nitrite Release From Organic Nitrites Enhances Nitric Oxide Bioavailability in Mammalian Cells. doi.org/10.1002/chem.2025028…

Glutathione‐Triggered Nitrite Release From Organic Nitrites Enhances Nitric Oxide Bioavailability...

This study provides a three-in-one strategy for the generation of nitrite under physiological conditions, measurement of glutathione levels, and determination of the relative amounts of nitric oxide...

chemistry-europe.onlinelibrary.wiley.com
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Congratulations to @yahoosahoo Sagar Kumar and @mugeshg !
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