@NasuLab_IBC

Biosensor engineer

Joined March 2021
  • Tweets280
  • Following279
  • Followers452
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Yusuke Nasu retweeted
Jin Zhang Lab@jinzhanglabOct 19
📢 New review from the Zhang Lab in @naturemethods led by @AMMGest ! Explore recent advances in fluorescent proteins and biosensors, including improved photostability, high-throughput screening, quantitative imaging, and multiplexing.🔬 Check it out! doi.org/10.1038/s41592-026-0…

Recent developments of fluorescent proteins and biosensors driven by cross-disciplinary insights

Nature Methods - This Review summarizes recent developments in fluorescent protein technology, including the engineering of fluorescent biosensors.

nature.com
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Yusuke Nasu retweeted
K-P Wu@KPWu11Oct 14
biorxiv.org/content/10.64898… Our latest preprint. It demonstrates how AI agent (here Claude Codex Opus 5.5, released on Sept. 22nd) accelerates 3D structure model building and refinement with a high-quality, publication-ready structure.

AI agent supervision of structural model building and refinement

Structural model building and refinement need many decisions between different programs. These decisions often depend on an experienced researcher who knows how the programs work together and how to...

biorxiv.org
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ラボのウェブサイトができました！研究内容やメンバーを紹介しています。ぜひご覧ください🌱 sites.google.com/view/shirak…

SHIRAKAWA LAB

Our research aims to uncover the molecular mechanisms by which plants have evolved diverse cell types, morphologies, and adaptive capabilities in response to changing environments. We will primarily...

sites.google.com
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🔬Publication - by Dr. Hsin-Yung Yen @ACSPublications A native MS platform utilizing #nanobodies was created to reveal structural diversity, distinct receptor conformations, and dynamic activation mechanisms at the #GPCR #intracellular interface. doi.org/10.1021/acs.analchem… @biochem

Native Mass Spectrometry Reveals Ligand-Specific Conformational Heterogeneity of the β1-Adrenergic...

Abstract. G protein-coupled receptors (GPCRs) are central physiological signal transducers and represent a primary class of therapeutic targets. While emer

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Yusuke Nasu retweeted
Liangyi Chen
@Orangeroad2017Oct 8
1/3 MIMAS is out in Science Advances: a 2.31-g open-source microlens-array miniscope for cellular-resolution imaging across ~4 × 4.5 mm² of dorsal cortex in freely behaving mice. doi.org/10.1126/sciadv.aei87…
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Yusuke Nasu retweeted
Neurotar@Neurotar_teamOct 6
Lactate meets neuronal activity! 🧠⚡️ Yusuke Nasu's team @AcadSinica & collaborators in 6 countries present eLACCO3 & R-eLACCO3, green & red lactate biosensors👏👏👏
Yusuke Nasu
@NasuLab_IBCOct 5
1/5 New preprint! 1/5 🟢🔴 New preprint! Meet eLACCO3 & R-eLACCO3: fast, Ca2+-independent green/red biosensors for extracellular lactate imaging. From protein engineering to multiplexed imaging in vivo. biorxiv.org/content/10.64898…
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Replying to @NasuLab_IBC @CERVO_ULaval
Huge thanks to all our coauthors and collaborators. What would you explore with these sensors? We'd love your feedback! #Biosensors #ProteinEngineering #Lactate
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5/5 Ready to image lactate, inside or out? Plasmids are expected to be available to order from Addgene in the next 1–2 days! AAVs are available from @CERVO_ULaval.
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4/5 For sensor developers: going extracellular takes more than a signal peptide! We combined LldR-based sensing, cysteine substitutions, linker engineering, directed evolution, and optimized surface targeting. Engineer for the environment, not just the test tube.
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3/5 Want to image lactate INSIDE cells? We also introduce iLACCO2 & R-iLACCO2: green/red intracellular sensors with large fluorescence responses and multiple affinity variants. More options for matching your sensor to your metabolic question!
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2/5 Not just bigger signals. eLACCO3 & R-eLACCO3 reveal glucose-evoked extracellular lactate oscillations that earlier variants often missed. Faster responses and recovery, with improved sensitivity, help capture dynamics at the cell surface.
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1/5 New preprint! 1/5 🟢🔴 New preprint! Meet eLACCO3 & R-eLACCO3: fast, Ca2+-independent green/red biosensors for extracellular lactate imaging. From protein engineering to multiplexed imaging in vivo. biorxiv.org/content/10.64898…
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New Cell paper from the lab today! We reworked photoswitchable GFP to control gene editing by Cas12f in mice using AAV delivery and ultrasound-triggered luminescent nanoparticles Work of postdoc Daesun Song in close collaboration with Guosong Hong's lab Thread in my other name
Michael Lin, MD PhD 🧬@michaelzlinSep 28
Today our lab is excited to share a new study in Cell: “Non-invasive control of gene editing in vivo by photoswitchable Cas12f and focused ultrasound.” We engineered a compact CRISPR system that can be activated at specific locations in the body using focused ultrasound (🧵)
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【拡散希望】生理研の分子細胞生理領域で教授公募中です！ 歴史的に膜・チャネルの部門ですが、それにとらわれず広く面白い分子細胞生理学を推進している方を求めています。少しでもかすると思われる方は是非出してみてください+周知お願いいたします。(萩) jrecin.jst.go.jp/seek/SeekJo…

JREC-IN | 大学共同利用機関法人自然科学研究機構生理学研究所分子細胞生理研究領域教授の公募について

イノベーション創出を担う研究人材のためのキャリア支援ポータルサイト

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We're searching for an assistant/associate professor in Bioengineering at Stanford! If you're using cutting-edge engineering approaches to understand or control biological systems in useful ways (medical, environmental, etc), we'd love to hear from you! facultypositions.stanford.ed…

Assistant Professor or Associate Professor without Tenure – Stanford University Department of...

The Department of Bioengineering at Stanford University invites applications for a tenure-track faculty position at the rank of Assistant or untenured Associate Professor. We give high priority to...

facultypositions.stanford.edu
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A compact protein pair, FenixS and Ash1, heterodimerizes upon red light activation for optogenetics. nature.com/articles/s41592-0…
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Yusuke Nasu retweeted
神野圭太@keita_kaminoSep 22
#拡散希望 生命科学分野の博士学生、ポスドクの方、ぜひこちらに応募して研究の話を聞かせてください。 出張費用は全てこちら持ち、特に優れた研究者には独立して自分のラボを立ち上げる機会や、フェローシップ等の支援が与えられます。 詳細はこちら：imb.sinica.edu.tw/imb_yrf/
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Yusuke Nasu retweeted
Ching-Lung Hsu@hiallen72Sep 16
New lactate sensor developed at Academia Sinica! @AcadSinica @IBCSinica @NasuLab_IBC nature.com/articles/s41467-0…

A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate...

Nature Communications - l-lactate is a key metabolite supporting neuronal activity, but methods to monitor l-lactate dynamics alongside neuronal activity in vivo have been limited. Here, authors...

nature.com
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Replying to @hiallen72 @AcadSinica @IBCSinica
Thank you Ching-Lung!
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Yusuke Nasu retweeted
Alice Ting
@aliceytingSep 15
Stanford Bioengineering faculty search: Apply by Sept 30! Bioengineering is defined broadly: if you are engineering at the level of biomolecules, cells, tissues, organisms, or using/developing advanced engineering techniques to study these systems - please apply! facultypositions.stanford.ed…

Assistant Professor or Associate Professor without Tenure – Stanford University Department of...

The Department of Bioengineering at Stanford University invites applications for a tenure-track faculty position at the rank of Assistant or untenured Associate Professor. We give high priority to...

facultypositions.stanford.edu
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