Engineer and problem solver with an interest in nutrition and n=1 personal experimentation in diet, exercise and lifestyle. Alter-ego of @VirtuallyNathan
Redmond, WA
Joined June 2018
- Tweets4.6K
- Following645
- Followers2.1K
- Likes1.9K
Nathan Owens retweeted
Today we're announcing our app, CareDenza. Our mission is to simplify your care journey, helping caregivers and patients alike stay on top of medications, appointments, follow-ups, metrics, and treatment plans. Learn more at caredenza.com
Another Nature paper on Cysteine this week!
“Cysteine depletion triggers adipose tissue thermogenesis and weight loss”
nature.com/articles/s42255-0…
@anabology @Joeb_AD
"Unravelling cysteine-deficiency-associated rapid weight loss"
"conditional cysteine restriction resulted in the most substantial weight loss [...] amounting to 30% within 1 week. We found that cysteine deficiency activated the integrated stress response [...] leading to the induction of GDF15 and FGF21"
nature.com/articles/s41586-0…
"Unravelling cysteine-deficiency-associated rapid weight loss"
"conditional cysteine restriction resulted in the most substantial weight loss [...] amounting to 30% within 1 week. We found that cysteine deficiency activated the integrated stress response [...] leading to the induction of GDF15 and FGF21"
nature.com/articles/s41586-0…
CoA scarcity stalls β‑oxidation and the TCA cycle, forcing a wasteful spill‑over of glycolytic and TCA intermediates into urine, amplifying the integrated‑stress‑response that drives GDF-15 and FGF21 transcription; more details in: biorxiv.org/content/10.1101/…
Human data:
N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids.
SAAR led to a ~ 20% greater weight loss compared to controls (β 95% CI - 1.14 (- 2.04, - 0.25) kg, p = 0.013)
pubmed.ncbi.nlm.nih.gov/3819…
I don’t really drink much anymore, nor do people in my family. I drank in college, but that’s about it.
