@NeochoritisLab

We have a strong focus on synthetic organic chemistry and the basic tool of our strategy are Multi-Component Reactions (MCRs). #neolab

 University of Crete
chemistry.uoc.gr/neochoritis/
Joined May 2022
  • Tweets62
  • Following145
  • Followers87
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochorJan 27
Multicomponent reactions as a molecular prism: simple inputs are refracted into rich molecular diversity across the chemical space! Nice idea for the cover of the thematic issue on MCRs beilstein-journals.org/bjoc/… @BeilsteinInst @NeochoritisLab #MCRs
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor1 Oct 2025
Can we learn a molecule how to hold still? Atropos and time are always interconnected, even from Greek mythology. A very nice MCR summit, with interesting chemistry here in olomouc, Czech republic
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor14 Jul 2025
🚨New paper out in Nature Communications! Scaffold hopping + MCR chemistry to design non-covalent molecular glues for the 14-3-3/ERα complex. A step forward in PPI-targeting drug discovery @University of SanFrancisco! @NeochoritisLab @NatureComms @UOC_gr nature.com/articles/s41467-0…

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex

Nature Communications - Molecular glues have great potential for drug discovery if they can be systematically discovered. Konstantinidou, et al describe a scaffold-hopping approach using...

nature.com
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor3 May 2025
How you evolve an imaging agent into a potent therapeutic? Thanks everybody for this fruiful collaboration! doi.org/10.1002/chem.2025015… @UOC_gr @NeochoritisLab @ChemEurope @ChemEurJ #MCRs
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor3 Apr 2025
Proxybinders! Glues and more!!! Tnx to the hard work of Marios and Michalis! @UOC_gr @NeochoritisLab #MCRs #helmedchem2025
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Neochoritis Lab retweeted
Chemistry Europe@ChemEurope24 Mar 2025
#EurJOC Diving into the Shielding Surfaces: Construction of Atropisomeric Axes via Multicomponent Reactions (Constantinos G. Neochoritis and co-workers) @UOC_gr @kneochor @NeochoritisLab #openaccess 🔓 onlinelibrary.wiley.com/doi/…

Diving into the Shielding Surfaces: Construction of Atropisomeric Axes via Multicomponent Reactions

We successfully designed and synthesized a diverse library of atropisomeric molecular systems using a scaffold hopping strategy based on the GBB-3CR. Structural and computational analyses revealed...

chemistry-europe.onlinelibrary.wiley.com
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor10 Mar 2025
How can we exploit CH-π interactions and shielding surfaces to tweak conformations of known scaffolds? Thanks everyone for this work! chemistry-europe.onlinelibra… @EurJOC @ChemEurope @NeochoritisLab @UOC_gr @ELIDEK_HFRI #MCRs #Neolab
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor17 Feb 2025
Interrupting the route of known reactions can lead to novel chemotypes. By installing the oxo and acid functionalities on the same carbon, interrupted Ugi and Passerini reactions were discovered! doi.org/10.1021/acs.orglett.… @NeochoritisLab @ELIDEK_HFRI @ACSPublications @JOC_OL #MCRs

Navigating Unexplored Territories of the Interrupted Ugi and Passerini Reactions toward Peptidomi...

Abstract. Interrupted reactions redirect established processes, often resulting in unexpected and novel outcomes. By employing a building block containing

pubs.acs.org
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor24 Jan 2025
C1 annulations are never outdated! Thanks everybody for this smart way of utilizing formamide in a sustainable way! 10.3762/bjoc.21.13 @NeochoritisLab @UOC_gr @EmpireikionIdryma #MCRs #Neolab
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor6 Nov 2024
Very glad to be hosted and present our work on MCRs at the National Hellenic Research Foundation!! @NeochoritisLab @ELIDEK_HFRI @UOC_gr #MCRs – at Attiki, Greece
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High Rotational Barrier Atropisomers (Constantinos G. Neochoritis @kneochor and co-workers @NeochoritisLab at @Uoc.gr) #OpenAccess onlinelibrary.wiley.com/doi/…

High Rotational Barrier Atropisomers

An unprecedented class of atropisomers based on Ugi reaction that exhibit exceptional rotational barrier is reported. The versatility of our approach enables the synthesis of atropisomers “by...

chemistry-europe.onlinelibrary.wiley.com
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Neochoritis Lab retweeted
EurJOC@EurJOC7 Aug 2024
Unraveling the Potential of Cyclic N-Sulfonyl Ketimines in the MCR Universe (Constantinos G. Neochoritis and co-workers) @Uoc_gr @kneochor @NeochoritisLab #openaccess onlinelibrary.wiley.com/doi/…
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor18 Jun 2024
Unraveling the Potential of Cyclic N‐Sulfonyl Ketimines in the MCR Universe! Well done guys, a very interesting scaffold with multiple functionalities!! chemistry-europe.onlinelibra… @UOC_gr @ELIDEK_HFRI @EurJOC @EEX_AGC @NeochoritisLab #Neolab #MCRs #MulticomponentReactions – at Heraklion, Greece
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor25 May 2024
Is really the MCR chemistry, an approach that a chemist should consider for her/his synthesis? The Ugi reaction as the green alternative towards APIs doi.org/10.1016/j.tgchem.202… @NeochoritisLab @UOC_gr @ELIDEK_HFRI #Women in Green Chemistry #neolab #MCRs – at Heraklion, Greece
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor18 Feb 2024
The 2nd PhD from our lab!! Very well done!! Congrats Michalis and we wish you all the best!!! @NeochoritisLab @UOC_gr @ELIDEK_HFRI #MCRs #macrocycles #atropisomers
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor6 Jan 2024
Our first for 2024! Useful heterocycles by MCR with bifunctionalized isocyanides in 1 step thieme-connect.com/products/… @ELIDEK_HFRI @UOC_gr @NeochoritisLab @EuChemS_DOC #MCRs #neolab – at Heraklion, Greece
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Interested in using CO2 in chemical synthesis? Take a look at "C1 functionalization of imidazo heterocycles via carbon dioxide fixation" by Constantinos G. Neochoritis & co. @DinosN6 @NeochoritisLab Read the #OpenAccess communication here 👇 buff.ly/488oMVa
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor26 Nov 2023
After tedious lab work, nice cretan food and wine is needed! Congrats to all of you guys @NeochoritisLab outing
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Neochoritis Lab retweeted
EurJOC@EurJOC15 Nov 2023
Congratulations @kneochor @NeochoritisLab from the whole Editorial Team at EurJOC for being selected as the winner of the EurJOC - Association of Greek Chemists (AGH) Award 👏👏👏
Neochoritis Lab@NeochoritisLab13 Nov 2023
EurJOC AGH @EurJOC just awarded Assistant Professor C.G. Neochoritis @kneochor at #ACC2023 for the Best Research Article by an Early Career Researcher! 🎉🎉🎉 #November2023 #Uoc #neolab
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Neochoritis Lab retweeted
Nikos Hatzakis lab@NHatzakis15 Nov 2023
So long lovely #Thessaloniki . Had a fantastic time in #Acc2023 meeting some top Greek (bio)chemists . Fantastic work from @ILykakis, @zografos_alex Vaso sarli , @MTerzidis , from @Auth_University @NeochoritisLab @KokotosCG, @arseniyadis ,nikos elefhheriadis @ManolikakesLab etc
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