Surgeon. Lover of all things science. Organ preservation, transplantation, and regeneration in particular. Torino 🇮🇹 Liège 🇧🇪
Belgium
Joined August 2021
- Tweets162
- Following212
- Followers149
- Likes408
Honored to be among the first authors of this spectacular team work & very proud to have led the #LiverTransplant arm of this study!
We have shown that #ferroptosis is a promising therapeutic target to safely transplant high-risk grafts!
Thx @CellCellPress for the highlight!
Now online! Ferroptosis inhibition enhances liver and lung graft function dlvr.it/TSSFzR
99
Nicholas Gilbo retweeted
1/ 🧵 I had the honor of leading the #liver arm of a new study just out in @CellCellPress, and I'll say it plainly: the liver data were spectacular! authors.elsevier.com/sd/arti…
A single ferroptosis inhibitor given through cold flush and static storage, rescued high-risk DCD grafts!
1/ 🧵 I had the honor of leading the #liver arm of a new study just out in @CellCellPress, and I'll say it plainly: the liver data were spectacular! authors.elsevier.com/sd/arti…
A single ferroptosis inhibitor given through cold flush and static storage, rescued high-risk DCD grafts!
6/❓What's next for the liver group.
@GIGA_ULiege and #CREDECLab we're now pushing ferroptosis inhibition into the harder problems:
🔵steatotic liver reconditioning under long-term MP
🔵cholangiocellular IRI — the silent driver of late failure
🔵Aim: a first-in-human trial!
1
79
7/ Thanks to an extraordinary consortium and in particular to @TomVBerghe for involving me in this project and making me discover this exciting new avenue of translational research in #livertransplantation
1
58
Honored to have my @frsFNRS postdoc fellowship renewed!
Grateful for the chance to explore:
🧫 #organoids & cholangiopathy
⚙️ Split liver #NMP
🧲 Ferroptosis in transplant
💥 Resensitizing CCA
Exciting work ahead — thanks for the support! #TransplantResearch
1
3
179
1/ #ESOT2025 comes to a close!
Our team @CHULiege & #CREDEC was proud to contribute — from building the 🇪🇺 machine perfusion registry to presenting research & lectures on:
🔮the future of organ assessment & repair
🧫 Cholangiocyte #organoids
🧬 MSC therapy during kidney #NMP
1
3
165
2/ Incredible science, meaningful conversations, and lots of memorable moments — including our team photo 📸
Huge thanks to @ESOTtransplant for an outstanding congress.
Already looking forward to #ESOT2027 in Prague!
Nicholas Gilbo retweeted
Exciting news!
🌍 We are launching a new membership to make our programmes accessible to healthcare professionals in low- and middle-income countries.
Let’s create opportunities together because talent knows no borders!
#PoweredByESOT w/ @gabriel_oniscu
When survival of pt w/ unresectable CRC #liver mts gets better than pt w/ resected mts you start asking yourself if we have the moral obligation to offer #LT to all CRC mts despite the limited donor pool... Groundbreaking study & exciting new research ahead! #TransplantOncology
Liver transplantation + CTx vs CTx in unresectable CRC liver metastases
🔎TransMet randomised trial
@TheLancet
doi.org/10.1016/S0140-6736(2…
👉5-yr OS: 56.6 vs 12.6%
👉Recurrence after LTx: 72%
🧐Impressive study, impressive results
❗️LTx valid option in highly selected pts
@myESMO @EASLedu @ILCAnews #livertwitter
2
431
Honored to be awarded a Lecturer position in clinical medicine at @UniversiteLiege!
Thanks to the Rector and Faculty of Medicine for this opportunity & the insightful welcome seminar.
Excited to inspire students in #AcademicSurgery & #transplant research!
linkedin.com/posts/anne-soph…
2
100
Nicholas Gilbo retweeted
On 29 August, the 11th Living Donor Abdominal Conference will kick off with the 3rd Workshop on Living Donation that focuses on #ESOT_YPT to discuss about living organ donation in the presence of senior faculty from Europe, USA and Asia. Following the Workshop, participants are invited to attend the subsequent main conference on 30 and 31 August 2024 for free.
Applications deadline: Monday, 1 July! More information ⤵️
Endorsement #PoweredByESOT
@frank_dor @DabareDilan @CDudreuilh @LornaMarson @Lucreziafurian @ValeriaMas11
go.esot.org/LD_abdominal_con…
Nicholas Gilbo retweeted
Liver @xenotransplantation. Better and more exciting news to come soon…
@ASTSChimera @_ILTS_ @AASLDtweets
@islsstudygroups @ttsorg @SPLIT_TTS @IXAYIC
First pig-to-human liver transplant recipient 'doing very well' nature.com/articles/d41586-0…
💡Main takeaways:
1️⃣ Pre-existing injury, especially WI, affects inflammation during NMP
2️⃣ Continuous #liverNMP reduces inflammation even with severe WI injury
3️⃣ Unlike in end-ischemic NMP, where pro-inflammatory cytokines peak early and are higher in DCD than DBD livers
7/n
1
53
🔚: there is more than meets the eye!!!
🟢 The relation of #NMP & inflammation is complex
🟢 Severity of ischemic injury & timing of NMP may affect inflammation “on-pump”
🟢 Early NMP may better preserve DCDs.
🔜 the next study?
Inflammation in continuous ↔️ end-ischemic NMP!
42
💡Main takeaways:
1️⃣ Reoxygenation during NMP triggers inflammation "on-pump" even w/short ischemic injury
2️⃣ but #liverNMP effectively reduces inflammation
3️⃣ The signature of this inflammation differs from that of IRI
🧐 Does this apply with severe pre-existing injuries?
4/n
1
35
➡️
🧪In our 2nd study, @JorisBlondeel procured 🐷 livers either immediately or after 60’ warm ischemic injury.
All livers underwent #NMP for 6h followed by WB-NMP for 12h to simulate a transplant.
Perfusate pro- & anti-inflammatory cytokines were measured and compared.
5/n
1
43