Neuroscience PhD student @Pin_Harvard, Andermann Lab | Solving consciousness via neuromodulators | formerly Mao/Zhong labs @ Vollum Institute
Boston, MA
Joined March 2017
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Nearly all neuromodulators & neuropeptides are integrated through GPCRs to converge onto the cAMP pathway. However, in vivo imaging of cAMP remains challenging.
We develop new sensors and demonstrate compartmental cAMP dynamics in neurons during behavior: nature.com/articles/s41592-0…
The only person I know to have written an entire review before finishing their qualifying exams: the indominable @GizemTerzioglu_
In my first, first-author publication, @YoungPearseLab and I review what’s known about the role of inflammation in AD, contributions of the NLRP3 inflammasome to microglial inflammatory response and the known intracellular functions of SHIP1 in myeloid cells.
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Fantastic work from @Jonna_Singh_ & @andrewlutas! Critical push forward in our understanding of how intracellular signaling can translate fast neurotransmission into other timescales.
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Crystian Massengill retweeted
An optimized cAMP sensor enables live-monitoring of physiological signaling dynamics in mouse neurons in vivo. #NBThighlight nature.com/articles/s41592-0…
Crystian Massengill retweeted
cAMPFIREs: Improved genetically encoded sensors for in vivo subcellular imaging of cAMP.
@Oliver_Snacks @BaylessLandon @HainingZhong @VollumInstitute
nature.com/articles/s41592-0…
cAMP imaging may be used to infer the functional dynamics of upstream GPCRs and neuromodulators, analogous to using calcium imaging to infer neuronal electrical activity. We hope cAMPFIREs are another step toward bettering our understanding of neuromodulation in the intact brain.
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cAMPFIREs are available on Addgene: addgene.org/search/catalog/p….
Many thanks to my PIs @HainingZhong and Tianyi Mao, and coauthors @BaylessLandon @byneuron @ElizabethCebul, Cesar Ceballos, Maozhen Qin, Evan Wilson, Matt Whorton, Isabelle Baconguis, James Cahill, & Arpita Bharadwaj,
Crystian Massengill retweeted
Wonderful to see @AquinSimon's PhD work from the Lüthi lab out in Science today. He describes compartmentalized dendritic plasticity in amygdala projection neurons during fear learning - using in vivo 2P imaging through GRIN lenses. Have a look:
science.org/doi/10.1126/scie…
Our new suite of cAMP sensors now online: biorxiv.org/content/10.1101/…
Highlights:
- 10-fold increased sensitivity to cAMP, enables detection of physiological levels of NMs;
- Single/subcellular imaging reveal compartmentalized/heterogenous signaling in vivo during behavior...
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cAMPFIREs and binding mutant variants are now available on Addgene! addgene.org/browse/article…
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Crystian Massengill retweeted
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Do you study Appetite? Nausea? Pain? Itch? Thermoregulation? Breathing? If so, you may find something valuable in our new study of the parabrachial nucleus.
onlinelibrary.wiley.com/doi/…
Featuring organoid queen @GizemTerzioglu_ !
To pave the way for the future, we also need to take a good look at how we’re teaching and training STEM students in schools and universities. All of us who work in STEM need to ensure we’re creating safe, welcoming, and flexible environments. (7/9)
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Crystian Massengill retweeted
Why do I have to adopt some "ism" here? I don't want to play your game. It seems to me a waste of time. If solid data supporting dualism or panpsychism (whatever they really amount to) are presented, I am listening. I want data.
A metaphysical map of consciousness studies.
Where do you land? @Philip_Goff @keithfrankish @patchurchland @danieldennett @BernardoKastrup @PeterSjostedtH youtu.be/g1BFEffFugY
Crystian Massengill retweeted
Our paper on pain-breathing interaction is out today. Kudos to everyone involved! Especially @ShijiaLiu1 for her hard work and perseverance. bit.ly/3IXsuFo
Greatly looking forward to this! Heavily inspired by @teissere’s remarkable courses Mind & Brain and States of Consciousness @Muhlenberg. Harvard affiliates can sign up below: forms.gle/f862gDbehf1tEcZx6
Meet Crystian Massengill, the instructor of the January@GSAS GSC Mini-Course: Thinking about Consciousness! Find further details and enroll via engage.gsas.harvard.edu/even….
#JanuaryAtGSAS #FindYourCenter⠀
@HarvardGSAS
ALT A person smiling for the camera.
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Crystian Massengill retweeted
It's an honor to be working with @cziscience, @ShamKakade6 and many others to build the Kempner Institute at @Harvard. It will push and blur the boundaries of and between computational neuroscience/AI/ML to learn how the brain computes, improve AI/ML and better lives of people.
With a $283M operating surplus and $11B growth in endowment last year, @Harvard can apparently spend money on anything but can’t match increases in cost of living, give full healthcare benefits, or provide access to #realrecourse. I stand with @hgsuuaw. #HarvardOnStrike
Survivors dealing with the Title IX process deserve substantial protections. Harvard has been fully intransigent on any form of 3rd party arbitration, when history has shown that Universities protect abusers. More than any issue, @Harvard’s refusal to resolve this is baffling