I study the biology of moving cells! Postdoc in the Sixt Lab at the Institute of Science and Technology Austria
Wien, Österreich
Joined January 2020
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Spontaneous #tcell blast migration in a #microfluidics device. Amazing that some cells crawl on ceilling of the chamber!
#Microscopy #Immunology
Thanks alot for the invite and organizing this cool event! #tcellworkshop2024
Cell migration & communication session followed with amazing lectures held by researchers working not only in Czechia, but also in Austria and Germany!
@PDehio @IrmaSchabussova
Miroslav Hons, Martin Jaroš
#tcellworkshop2024 #cellmigration #cyimmunologists #immunology
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Check out this cool work from @luc_boeck and his team!
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Come join us in Brno - super excited to give a talk there! Very grateful for the invite @CYImmunologists
Join us for @CYImmunologists conference in Brno, 🗓️10-11th November! Check out the stunning program 👇👇👇 and see you all there!
@y_efis
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Philippe Dehio retweeted
An Actin Cushion Enables Dendritic Cells to Forge Paths While Maintaining a Coordinated Motion ! 🦠✨
Check out the latest story from @pRodrigues0_o and colleagues from @Sixt_Lab highlighted here 👀👇
prelights.biologists.com/?po…
@preLights #preprint
Philippe Dehio retweeted
Lymphoid stromal chemokines act as built-in "disruptors" of T cell-DC interactions for long-term preservation of T effector functionality @LukasAltenburg2 @Steinlab_unifr
biorxiv.org/content/10.1101/…
Philippe Dehio retweeted
Happy #MicroscopyMonday!
Here are some amoebae crawling into channels:
Super thrilled and thankful that my postdoc mobility grant is being funded by the @snsf_ch! 🥳 I will interrogate the cell biology of transmembrane protein recycling in amoeboid migration @ISTAustria in the @Sixt_Lab.
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Philippe Dehio retweeted
In our latest review @emboreports, we discuss the challenges of how cells actively position their organelles for functionality, and how this is coordinated with cellular motion. We also propose models of how organelles are moved w/o relying on anchorage.
embopress.org/doi/full/10.10…
Philippe Dehio retweeted
The sun is out 🌞, we @Sixt_Lab are brainstorming on actin based protrusions this week!
Philippe Dehio retweeted
The cichlid fishes of Lake Tanganyika are highly diverse. So are their viruses. Read our latest work in @CurrentBiology cell.com/current-biology/ful…
🚨🚨 Our preprint on how the lipid kinases VPS34 and PIKfyve regulate ameboid cell migration speed is out! A huge shout out to all amazing collaborators @adriaamarti @HessLab @KlausOkken @SoldatiLab @Michard_Celine (and more!)
biorxiv.org/content/10.1101/…
So what is happening? 👇
Not only T cells slow down when we manipulate this system but also DCs and neutrophils! Even cooler is the fact that Dictyostelium discoideum - a social amoeba - exhibits also speed defects when you knock out PIKfyve or the TRPML1 orthologue.
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This points towards an early evolutionary adoption of this systems to support amoeboid cell migration - which has previously been overlooked.
Now we are thrilled to get feedback from the community!
#Microscopy #CellMigration #TCells
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Philippe Dehio retweeted
🚨 PhD position alert 🚨
Thilo Köhler and Christian van Delden at @unige_en @hug_ge offer a position on clinical phage therapy of Pseudomonas aeruginosa and its microbiological basis 🧫💉🦠. It is funded by @NCCR_AntiResist and will be in collaboration with us. 👇🏼
Philippe Dehio retweeted
Interested in chemokines and cancer? Have a look at our review @NatureRevCancer – at Cambridge, MA
Happy to share a link to our review of chemokines in cancer in @NatureRevCancer. We explore how chemokine programs that evolved for inflammation, tissue repair, antimicrobial defense etc shape tumor microenvironments. Tx to @LukasAltenburg2 and Julia Lill
rdcu.be/ds6Cl
Enjoy some retrograde actin flow in a T cell for #FluorescenceFriday. This process propels amoeboid migrating cells forward. Stay tuned for our upcoming preprint, describing a novel regulator of these cytoskeleton dynamics!
Two days ago, I defended my PhD thesis. I would like to express my deep gratitude to my supervisors Christop Hess @HessLab, Matthias Mehling, Michael Sixt @Sixt_Lab, Dirk Bumanm @BumannLab, colleagues and collaborators for all of their support!
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