Manav Pathania | @manavpathania.bsky.social retweeted
Excited to share that Spatial Hi-C-RNA is now out in @CellCellPress! It brings the 3D genome into spatial multi-omics by co-mapping chromatin architecture and gene expression in the same tissue section. Congrats to the whole team! cell.com/cell/fulltext/S0092…
Manav Pathania | @manavpathania.bsky.social retweeted
Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science.
Today @nature, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/
nature.com/articles/s41586-0…
Manav Pathania | @manavpathania.bsky.social retweeted
Out today in @Nature: Daniel Lim, MD, PhD (@danlimlab) and colleagues @UCSF have discovered that genes are controlled not only by DNA sequence and chemical epigenetic marks, but also by where they are located inside the nucleus. 🔗nature.com/articles/s41586-0…
danlimlab.ucsf.edu
ALT Drawing of switch from lamina-associated domains (LAD) to speckles-associated domains (SPAD) during differentiation from radial glia (RG) to excitatory neurons (EN).
Manav Pathania | @manavpathania.bsky.social retweeted
Sometimes I get an anonymous comment on my blog of someone sharing sad truth and it really sucks.
One of my hopes for AI in science, and perhaps it's a naïve one, is that cases of sophistry such as described here are exposed more readily and broadly.
liorpachter.wordpress.com/20…
Manav Pathania | @manavpathania.bsky.social retweeted
Excited to announce our study (w/ @RukmanThota & @MaxKrummel) published today @Nature:
Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells.
nature.com/articles/s41586-0…
#immunology #cellbiology @immunox @ucsf
Manav Pathania | @manavpathania.bsky.social retweeted
WOW!!
Identification of a neural circuit that enables safe, long-term torpor in mice biorxiv.org/content/10.64898…
Manav Pathania | @manavpathania.bsky.social retweeted
CAR-neutrophils produced in vivo to treat glioma go.nature.com/4mOTMSI
Manav Pathania | @manavpathania.bsky.social retweeted
As promised, here's the deep dive on our recent article! Did you know the brain's "sewer drains" (dural sinuses) aren't passive pipes—they're dynamic, ruffling structures that actively guard immunity & regulate pressure?
As both a co-author and President & Founder of @neurosimplicity, I am excited to spotlight this groundbreaking discovery from the McGavern lab @NIH_NINDS in @Nature. Our Imaging Suite helped map the amazing cranial & neurovascular connections in unprecedented 3D detail! 🧠🔬
Link: rdcu.be/e4A8i
#Neuroimmunology #BrainImmunity
ALT Extended Data Figure 2 from Monaghan et al Nature 2026 shows the dorsal cranial vasculature mapped automatically from micro-CT images using the Neurosimplicity Imaging Suite, which is an on-premises secure private cloud neuroscience data processing platform. Figure adopted with permission.
Manav Pathania | @manavpathania.bsky.social retweeted
Nature research paper: Highly dynamic dural sinuses support meningeal immunity
go.nature.com/4qVnxlm
Manav Pathania | @manavpathania.bsky.social retweeted
Nature research paper: A disease model resource reveals core principles of tissue-specific cancer evolution
go.nature.com/4cIrt5i
Manav Pathania | @manavpathania.bsky.social retweeted
Step 1: Insert bacteria ("Wolbachia") into mosquitoes.
Step 2: Release mosquitoes.
Step 3: Watch Dengue rates plummet.
Phenomenal results from Singapore.
Link: tinyurl.com/59c9t67u, by Lim et al.
Manav Pathania | @manavpathania.bsky.social retweeted
I am excited to share our latest preprint, in which we demonstrate that systemic hypoxia suppresses solid tumor growth.
This has been a tremendous collaborative effort in the labs of @IshaHJain and @Genophoria at @GladstoneInst, @ArcInstitute, and @UCSF.
biorxiv.org/content/10.64898…
Manav Pathania | @manavpathania.bsky.social retweeted
3 new reports @CellCellPress on the mechanistic underpinnings of multiple sclerosis and Epstein-Barr virus involvement
cell.com/cell/fulltext/S0092…
cell.com/cell/fulltext/S0092…
cell.com/cell/fulltext/S0092…
Manav Pathania | @manavpathania.bsky.social retweeted
New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep).
Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep.
They found what actually matters - and why some sleeping pills might undermine it 🧵
Manav Pathania | @manavpathania.bsky.social retweeted
'Night science' is what you do when you're not sure what's the question.
Manav Pathania | @manavpathania.bsky.social retweeted
Prevention beats cure, which is why it's so exciting that Lenacapavir, a twice-yearly HIV preventative, just got approved for the first time (by the FDA)
Why is it such a big deal?
When trialled (in women in South Africa and Uganda) there were 0 HIV infections
🧵
Manav Pathania | @manavpathania.bsky.social retweeted
I am excited to present our new study out in @NatureMedicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the @wysscoray lab. 🧵1/12
Full study 🔗: nature.com/articles/s41591-0…
Manav Pathania | @manavpathania.bsky.social retweeted
We are walking the Ullswater Way with @OscarsCharity in May.
Learn more and donate here: justgiving.com/team/thalia
#braintumours #childhoodcancer #cancer
Manav Pathania | @manavpathania.bsky.social retweeted
Too many people take biomedical innovation for granted.
Manav Pathania | @manavpathania.bsky.social retweeted
"More than 99% of new drug approvals (2010-2019) were funded by NIH. Why dismantle the engine that made the U.S. a world leader in innovation and drug development ? #DoNotDefundScience jamanetwork.com/journals/jam…