Peptide Directory. Suppliers in the UK, US and AU, peptide information, and the research behind them. Informational only. Not medical advice. We sell nothing.
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Joined September 2026
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Can you keep your strength while losing weight on tirzepatide? 🏋️
In a 40-week RCT of 120 adults aged 50–70, 3 weekly weights sessions didn't change weight loss (~22 kg) but cut lean tissue loss by 1.1 kg, and strength rose instead of falling.
nature.com/articles/s41591-0…
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Could a GLP-1/glucagon peptide help people cut heavy drinking? 🍷
In a 24-week phase 2 trial (~100 adults), pemvidutide cut heavy drinking days by 4.2 a week vs 2.75 on placebo, and 42% vs 17% had none by the end.
Company-reported conference data.
ir.altimmune.com/news-releas…
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Can a peptide work as a daily pill for arthritis? 💊
In a 552-person phase 3 trial, oral icotrokinra gave 58% a meaningful joint improvement at 16 weeks vs 41% on placebo, and 57% vs 14% clearer skin.
J&J abstract, full paper to come.
acrabstracts.org/abstract/ic…
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Can a weight-loss peptide ease knee arthritis pain? 🦵
In two phase 3 trials (1,019 adults, NEJM), up to 70% on retatrutide halved their knee pain at 68 weeks vs 38% on placebo.
Lilly-funded; not built to test joint progression.
rheum-live.com/view/retatrut…
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Can semaglutide ease the heart pressure behind HFpEF? 🫀
In an 81-person randomised trial, a year of semaglutide cut exercise filling pressure by 10.6 mmHg vs placebo, and 54% vs 7% reached normal pressures.
Small, mechanistic trial.
nature.com/articles/s41591-0…
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Do GLP-1 drugs directly shrink muscle? 💪
In lab-grown muscle cells from older adults with obesity, semaglutide and GIP didn't trigger atrophy signals or block muscle-cell formation. Cell study only, but it fits lean-mass loss being indirect.
pubmed.ncbi.nlm.nih.gov/4298…
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Does semaglutide lower blood pressure too? 🩺
A new meta-analysis of placebo-controlled trials (about 20,000 people) found systolic pressure fell by around 3.5 mmHg vs placebo, rated high-certainty evidence. The diastolic change was small.
pubmed.ncbi.nlm.nih.gov/4298…
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Can a weekly GLP-1/glucagon peptide clear MASH liver inflammation? 🔬
In a 381-person phase 2b trial (Merck-sponsored), efinopegdutide resolved MASH in 56 to 63% vs 13% on placebo at 52 weeks. 7 mg looked best.
Abstract data, full paper to come.
clinicaltrials.gov/study/NCT…
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Can a peptide help immunotherapy before cancer surgery? 🧬
In a single-arm phase 2 study, ruxotemitide injected into melanoma tumours alongside pembrolizumab met its goal of at least 40% complete response at surgery.
Company topline, not yet peer reviewed. Phase 3 planned.
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Does semaglutide still help when kidneys struggle? 🩺
A new look at the FLOW trial (3,533 adults with type 2 diabetes and kidney disease) found lower HbA1c and weight vs placebo over 2 years at every stage of kidney function.
Post hoc analysis. Diabetes Obes Metab, 3 Nov
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Could GLP-1 drugs change drinking? 🍷
In US records for adults with type 2 diabetes, starting semaglutide or tirzepatide was linked to about half the rate of alcohol-related hospital or ER visits vs SGLT2 drugs.
Observational, so a link only. Diabetes Obes Metab, 3 Nov
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Which peptides actually have research behind them? 🧬
We've summarised 164 research papers across 28 peptides, from large human trials to early mouse and cell studies, each labelled by study type and linked to the source.
Some highlights 🧵
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Every paper has a plain-English summary, the study type, who or what was studied (people, mice or cells) and a link to the original.
We sell nothing. Filter by peptide or study type here 👇
peptidefix.io/research
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Can peptide-like molecules be built longer? 🧪
Chemists joined two short peptoid chains head to tail in water while keeping their enzyme-resistant backbone intact, a practical route to much longer peptoids.
Lab chemistry only. Biochemistry, 2 Nov
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GLP-1s or SGLT2s for fatty liver plus heart failure? 🫀
In US records for 8,550 matched pairs, GLP-1 users had lower mortality (7.0% vs 10.1%) and fewer acute heart failure diagnoses.
Observational, so a link, not cause and effect. Balkan Med J, 2 Nov
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