@PerrimonLab

Dr. Norbert Perrimon's lab at Harvard Medical School researches functional genomics, cell circuitry, and tissue homeostasis in Drosophila melanogaster.

 Boston, MA
perrimon.med.harvard.edu/
Joined December 2017
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ABC transporters support Drosophila intestinal stem and progenitor cells during cytotoxic challenge Dayton, Russo, Kolbert, Williamson, Balciunaite, DSouza, Becker, Hosage, Issa, Lu, Viswanatha, Kondo, Perrimon, Markstein doi: doi.org/10.64898/2026.10.05.…
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Spatial isotope tracing maps compartmentalized nutrient use across the adult fruit fly Moon, Huang, Blum, New, Park, Chen, Nishida, Pister, Nahid, Hu, Tennessen, Fraenkel, Asara, Davidson, Perrimon doi: doi.org/10.64898/2026.10.06.…
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FlyAnatoView: Visualization of Drosophila Single-cell RNA-seq Datasets on Anatomographs Hu, Kalina, Veal, Ewen-Campen, Tarryn Porter, Julia Song, Luo, Huang, Goutte-Gattat, Brown, Papatheodorou, Perrimon bioRxiv 2026.09.28.755010; doi: doi.org/10.64898/2026.09.28.…

FlyAnatoView: Visualization of Drosophila Single-cell RNA-seq Datasets on Anatomographs

Single-cell RNA sequencing (scRNA-seq) is a powerful approach for measuring the transcriptomic landscape at single-cell resolution. However, while scRNA-seq data reveals what genes each cell expres...

biorxiv.org
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FlyAnatoView: Visualization of Drosophila Single-cell RNA-seq Datasets on Anatomographs Yanhui Hu et al, bioRxiv 2026.09.28.755010; doi: doi.org/10.64898/2026.09.28.…
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Lipids regulate export of lysosomal enzymes from the endoplasmic reticulum. Xia B, Han M, Park I, Perrimon N. Proc Natl Acad Sci U S A. 2026 Sep 22;123(38):e2616684123. doi: 10.1073/pnas.2616684123. Epub 2026 Sep 17. PMID: 42752232
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The Drosophila Secretome Yanhui Hu1, Nahid Ausrafuggaman, Jenna Kalina, Austin Veal, Mujeeb Qadiri, Ah-Ram Kim, Norbert Perrimon doi: doi.org/10.64898/2026.08.24.…
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Yanagawa K, Perrimon N. Extracellular vesicles in Drosophila and mammals: Conserved mechanisms and emerging functional roles. EXO. 2026;1(3):202615. doi: 10.70401/EXO.2026.0014. PMID: 42598228
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Lee, et al. (2026). Antigen presentation by CD40+ MHC-II+ astrocytes promotes CNS autoimmunity. Nature. doi: 10.1038/s41586-026-10860-6. PMID: 42557325
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In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila. Marques et al. Elife. 2026 Aug 18;14:RP109422. doi: 10.7554/eLife.109422.
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A pro-apoptotic selection strategy enables CRISPR screening in mosquitoes and identifies Lachesin as a chikungunya virus entry factor Anja C. M. de Bruin et al. bioRxiv 2026.07.31.742019; doi: doi.org/10.64898/2026.07.31.…
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Lachesin is a mosquito receptor for multiple arthritogenic alphaviruses Plung et al. bioRxiv 2026.07.28.741058; doi: doi.org/10.64898/2026.07.28.…
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Hu, Y., Comjean, A., Gao, C., Veal, A., Yamamoto, S., Mohr, S.E. and Perrimon, N. (2026) DIOPT: the DRSC Integrative Ortholog Prediction Tool, 2026 update. Genetics. doi: 10.1093/genetics/iyag194. PMID: 42504133
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New paper: Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila. Huang K, Miao T, Chen Y, Dantas E, Sanford J, Asara JM, Moon SJ, Hu Y, Wang K, Han M, Goncalves M, Perrimon N. Nat Commun. 2026 Jul 3. doi: 10.1038 s41467-026-75074-w.
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New paper: Streptomyces produce a diphtheria toxin-like exotoxin that targets insects. Xu et al.Nat Microbiol. 2026 Apr 30. doi: 10.1038/s41564-026-02315-5. Online ahead of print. PMID: 42062574
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New paper: Bosch, J. A. et al. (2026) Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking. Nat Commun. doi: 10.1038/s41467-026-71763-8. PMID: 42009678
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Miao, T., Liu, Y., Qadiri, M., Dasseux, A., Asara, J. M., Hu, Y., Sun, X., Pliego-Alcántara, LDC., Dibble, C. and Perrimon, N. (2026) Renal coenzyme A (CoA) production from Vitamin B5 fuels stem cell proliferation and tumor growth. Nat Commun. doi: 10.1038/s41467-026-71716-1.
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hms.harvard.edu/news/not-wan…

Not Wanting To Eat Protein May Be Early Herald of Cancer Cachexia

Study in fruit flies uncovers earliest known sign of impending muscle and fat wasting

hms.harvard.edu
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Han. M., Xia, B., Kim, A-R., Filine, E., Stoneburner, E., Miao, T., Liu, Y., Zirin, J. and Perrimon, N. (2026) Phage display-mediated immuno-PCR to detect low-abundance secreted proteins in Drosophila. PNAS. 14;123(15):e2531777123. doi: 10.1073/pnas.2531777123. PMID: 41941621
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Petsakou, A., Filine. E., Li, M., Zheng, A., and Perrimon, N. (2026) Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms. Nature Communications. doi: 10.1038/s41467-026-70074-2. PMID: 41792134
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Lane, E., Petsakou, A., Liu, Y., Chen, W., Qadiri, M., Hu, Y. and Perrimon, N. (2026) Cholinergic signaling modulates intestinal pathophysiology in a Drosophila model of cystic fibrosis. PloS Genetics. 22(2):e1012048. doi: 10.1371/journal.pgen.1012048. PMID: 41701793
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