@PeterLyLab

Genome Integrity Lab | Associate Professor @CRI_UTSW @UTSWMedCenter. We study how mitotic errors and genomic instability drive cancer evolution.

 Dallas, TX
thelylab.org
Joined October 2018
  • Tweets2.4K
  • Following620
  • Followers2.4K
103Media
Peter Ly retweeted
J Cell Science@J_Cell_Sci16h
When cells in different phases fuse, nuclei play a mitotic tug-of-war Olga Afonso, Daniel Feliciano and Jennifer Lippincott-Schwartz investigate the fate of syncytia containing nuclei at different cell cycle stages. Highlight: journals.biologists.com/jcs/…
1
8
1
52
2,161
Our recent paper on CCAN organization was just out in @ScienceAdvances. We combined MD simulation with expansion microscopy to observe an interesting structure in the kinetochore. Congrats, @yj_sakai, Mariko, and @yasuhhirano17 !! Please check it out. science.org/doi/10.1126/scia…

CCAN forms the spherical shell-like structure in interphase kinetochores

The kinetochore is an essential structure for the faithful chromosome segregation during mitosis. The 16-protein complex known as the constitutive centromere-associated network (CCAN) localizes the...

science.org
3
12
3
43
4,020
The Department of Biological Chemistry at UCI is seeking a tenure-track Assistant Professor! This is a broad search across biomedical sciences, including genome stability. Join a dynamic department with great faculty benefits and year-round sunshine! recruit.ap.uci.edu/JPF10441

Assistant Professor of Biomedical Sciences (tenure track)

University of California, Irvine is hiring. Apply now!

recruit.ap.uci.edu
2
2
429
Out today in @JCellBiol Work from the Mogessie, @FachinettiLab & @DrSteffi labs reveals how CENP-A/B/C cooperate to maintain kinetochore function in oocytes and how declining centromere strength predisposes aging eggs to aneuploidy. @pewhealth @HFSP doi.org/10.1083/jcb.20260613…
7
30
1,403
Peter Ly retweeted
Hao Zhu Lab@Zhu_LabOct 19
We are looking to hire post-doctoral fellows to work on somatic mosaicism, regeneration, and cancer development, please reach out to me if you are interested! @CRI_UTSW
14
3
17
3,256
Peter Ly retweeted
Anton Henssen@anton_ghOct 15
Happy to share our new study published this week in @NatureGenet 🔥🔥🔥🔥 nature.com/articles/s41588-0…

Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival

Nature Genetics - Single-micronucleus sequencing and live-cell imaging of cancer cells, as well as analyses of biopsies from patients with neuroblastoma, reveal that ecDNA in micronuclei limits...

nature.com
3
14
52
4,488
That’s a wrap for FASEB Aneuploidy 2026! Thanks to all the attendees for making it a special meeting. The science was so out-of-this-world that NASA even launched a spaceship for us. 🚀 See you again in 2029! #ANESRC
4
27
1,030
🔬TWO MORE WEEKS remain to apply for any of our three open faculty positions at cri.utsw.edu/careers #relentlessdiscovery

Careers - Children's Medical Center Research Institute (CRI) | Dallas Texas

Children’s Medical Center Research Institute at UT Southwestern (CRI) is a joint venture of UT Southwestern Medical Center and Children’s ...

cri.utsw.edu
Children’s Research Institute at UT Southwestern@CRI_UTSWAug 19
Come be part of our #relentlessdiscovery and discover the treatments of tomorrow. Faculty recruitment through Oct. 15 👉 cri.utsw.edu/careers
3
4
741
Check out our latest, just out in @MolecularCell! We reveal how typically harmless forms of DNA damage synergise with DNA replication defects in ATM-deficient cells to drive cancer responses to PARP inhibitors—and propose that a similar synergy may contribute to A-T pathogenesis.
Molecular Cell@MolecularCellSep 28
Online Now: ATM safeguards DNA replication by restraining pathological repriming at endogenous base lesions dlvr.it/TVgxRM
2
16
36
1,524
Peter Ly retweeted
Peter Ly@PeterLyLabAug 19
We are recruiting new faculty at all levels who seek to solve fundamental problems in biology and disease. @CRI_UTSW is an exceptional and highly collaborative environment to build a research program and pursue ambitious science. Join us!
Children’s Research Institute at UT Southwestern@CRI_UTSWAug 19
Come be part of our #relentlessdiscovery and discover the treatments of tomorrow. Faculty recruitment through Oct. 15 👉 cri.utsw.edu/careers
16
30
4,843
😊 New preprint! In budding yeast, Dna2-intrinsic condensation regulates long-range DNA-end resection. Analyses suggest redistribution of condensate grammar in humans. Congrats to Chris Jordan and the Mekhail, Wyatt, Cowen & Hakem labs! More to come soon. biorxiv.org/content/10.64898…

Dna2-intrinsic condensation regulates DNA end resection and reveals evolutionary redistribution of...

Eukaryotic cells commonly use biomolecular condensation of DNA double-strand break (DSB) repair scaffolds and signaling assemblies to organize repair reactions in space and time. Yet whether DSB...

biorxiv.org
2
9
889
Peter Ly retweeted
Yuan He@YuanHeJHUSep 22
A big week for the lab! Two new papers on how cells repair DNA double-strand breaks: one on getting NHEJ started in chromatin, one on processing the ends before ligation. Years of work by a fantastic team.
1
26
163
8,357
New Online! Mechanisms and disease relevance of DNA break repair pathway choice dlvr.it/TVXnnC
29
1
100
5,693
How are mitotic chromosomes built? 🏗️ Our Review @TrendsGenetics revisits the classical chromosome scaffold model and connects it to condensins, topoIIα, and physical forces. We propose interphase chromatin domains as “building blocks”🧩of chromosomes: authors.elsevier.com/a/1nmwr…
2
41
3
114
7,867
Peter Ly retweeted
Anton Henssen@anton_ghSep 14
Very happy to share our new Perspective in Nature Reviews Genetics, led and written primarily by my colleague Liam P. Shaw: “The shared evolutionary capacities of plasmids and extrachromosomal DNA” nature.com/articles/s41576-0…

The shared evolutionary capacities of plasmids and extrachromosomal DNA

Nature Reviews Genetics - Plasmids in bacteria and extrachromosomal DNA in cancer both generate copy-number variation, alter gene expression and promote rapid adaptation. In this Perspective, Shaw...

nature.com
4
7
1,282
Excited to share our new @ScienceAdvances paper! During interphase, centromeres form 3D shells organized by the CENP-A chaperone complex at their core. Led by Hindol Gupta, with the @TakashiAkeraLab , Losada, and Shroff labs. science.org/doi/10.1126/scia…

The CENP-A chaperone complex spatially organizes centromeres

Centromeres, defined by CENP-A–containing nucleosomes, direct kinetochore assembly for spindle attachment. In mitosis, CENP-A and the constitutive centromere-associated network (CCAN) of the inner...

science.org
2
11
1
34
6,108
🎉 Excited to share the first preprint from the Panday Lab! biorxiv.org/content/10.64898… We identify FANCM as an adaptive genome-maintenance dependency in BRCA1-deficient breast cancer and uncover its role in restraining ongoing structural genome evolution.

FANCM restrains structural genome evolution and defines a synthetic lethal dependency in BRCA1-de...

BRCA1 -deficient cancers experience persistent replication stress and structural genome instability yet retain the capacity for sustained proliferation, implying reliance on compensatory genome-mai...

biorxiv.org
3
3
1
26
1,627
How did we come to understand cancer in the light of evolutionary theory? Nothing makes sense if not with population genetics! In our latest @NatureRevCancer review we unpack how population genetics theory applied to somatic cells allows us to measure and predict cancer evolution from molecular data. Computational modelling in oncology has gone a long way but we need to go much further. The frontier is combining evolutionary theory with machine learning. Link below👇
5
52
2
193
10,140
Peter Ly retweeted
Adrian Saurin@AdeSaurinSep 9
#Postdoc position available in my lab to study the role of senescence and senescence evasion in cancer therapy responses (available for up to 5 years) Check out saurinlab.com further details about project and lab culture in general. jobs.ac.uk/job/DSS226/post-d…

Mitosis lab studying kinase and phosphatase signaling

Saurin lab homepage - find out all about our research into mitosis, kinases and phosphatases.

saurinlab.com
2
27
64
4,122
1/ Out today in @Nature! 🧵 We mapped the mutational processes shaping 959 prostate cancer genomes from the Pan Prostate Cancer Group (PPCG), integrating SBS, ID, CX and complex SV signatures. Eight footprints account for the processes in 85% of cases nature.com/articles/s41586-0…

Integrated signatures define mutational processes in prostate cancer

Nature - Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.

nature.com
2
31
2
98
10,276
Load more