‼️ Now online in the #EHJ @ESC_Journals: The Vasc-PFA study 📖 academic.oup.com/eurheartj/a… @ehj_ed Our study provides important insights into the acute coronary vascular effects of monopolar biphasic #PulsedFieldAblation 🔬 Key findings: 👉 Acute, localized endothelial dysfunction occurs following coronary exposure to PFA, while vascular smooth muscle function remains preserved. 👉 The effects are site-dependent: endothelial dysfunction was least pronounced after cavotricuspid isthmus (CTI) ablation and most evident following great cardiac vein (GCV) and epicardial PFA. 👉 Selective endothelial injury with preserved smooth muscle cell function may explain the observed vasomotor dysfunction and why nitroglycerin can rapidly reverse clinically apparent coronary spasm despite persistent endothelial impairment. 📌 Why does this matter? Anatomical factors may influence electric field delivery and the degree of coronary exposure. The findings also raise important questions about the potential relationship between acute endothelial injury and delayed coronary complications, including myocardial ischaemia, ventricular arrhythmias, and longer-term vascular remodelling. #PulsedFieldAblation #Electrophysiology #CardiacElectrophysiology #Cardiology #CoronaryArteries #Arrhythmia #CardiacResearch @drjohnm @DrJasonAndrade @TinaBaykaner @DrRoderickTung @ftrae @peterkistler3 @ivroca @shivkumarmd @LuigiDiBiaseMD @nmarrouche @S_NarayanMD @Dr_Santangeli @atulverma_md @SCYap77 @VivekReddyMD @MoritzNies @jskoruth @arnelasaljic @DalgasSarah @PrashSanders @harry_crijns @Elliott_AD @kvernooy @Ed_Gerst @True_EP @Drdevignair @Mel_Gunawardene @jongichun @RolandTilz @Phiso_de lnkd.in/p/eNvPWUK9