@eLife ambassador. PhD cand @KAISTPR @SeoulNatlUni. Working on drug promiscuity💊, extremophile trait genomics🪸🦈, & disease evolution👾. Naively pluripotent.

Daejeon, Republic of Korea
Joined October 2014
Include

Only show posts containing:

Exclude

Hide posts containing:

Time range
-
Minimum likes
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
🧬 🤗 Nvidia just released a new protein design model, RFD4-Proteina, on @huggingface! RFD4-Proteina has a thinking setting (like an LLM). At high thinking, it produces 76.40 usable designs per GPU-hour on a benchmark of 24 binding targets, where the next best method managed 13.2. You can design protein sequences and all-atom structures together, conditioned on the molecular context you want to preserve: a binding target, an enzyme motif, a ligand, or selected structural features. Thanks @nvidia and University of Washington's Institute for Protein Design for making the model open source and available on the Hub! 🧬 Try the model on the demo space: huggingface.co/spaces/nvidia… 🤗 Model: huggingface.co/nvidia/RFD4-P… 📖 Blog post: huggingface.co/blog/nvidia/r…
5
20
2
93
3,487
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
AI+bio: the Escalante folks released a blog post yesterday, and as usual it's a banger, talking more about their multiplexed protein binding assay: blog.escalante.bio/endless-p… (I imagine this got lost amidst the securitypocalypse that landed yesterday.)
12
92
4,951
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
Derek Lowe mentioned my preprint in his "In the Pipeline" series which is very cool - big fan of his writing! science.org/content/blog-pos…
2
9
1
49
2,317
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
We need to do experiments to figure out exactly how these work. But there are way too many candidates! So we created an explorable website (compass.arcinstitute.org/) and MCP (compass.arcinstitute.org/age…) for the research community to mine the COMPASS clusters and make their own discoveries!
1
7
38
3,912