@Refael_Tal

A PhD student at @LabPMelamed Faculty of Biology, Technion - Israel institute of technology, Haifa, Israel.

Joined December 2018
  • Tweets43
  • Following180
  • Followers75
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Happy to share our latest work on the non-coding elements regulating Lhb which encodes the pituitary gonadotropic hormone that controls reproduction, involving an i-motif, eRNA and adjacent lncRNA through distinct mechanisms in a sex-specific context. link.springer.com/article/10…

An i-motif-regulated enhancer, eRNA and adjacent lncRNA affect Lhb expression through distinct...

Cellular and Molecular Life Sciences - Genome-wide studies have demonstrated regulatory roles for diverse non-coding elements, but their precise and interrelated functions have often remained...

link.springer.com
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@LabPMelamed
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Tal's PhD seminar...and before with @dor_shalev1 Details of her latest paper coming soon.
PhilippaMelamedLab@LabPMelamed23 Aug 2024
Can't believe Tal @Refael_Tal is really leaving us...what amazing presents she left us.
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I can't believe my PhD has come to an end, thanks to my amazing lab that was my second home for 6 years and of course huge thanks to my amazing mentor Philippa @LabPMelamed 🙏🏻
PhilippaMelamedLab@LabPMelamed23 Aug 2024
Can't believe Tal @Refael_Tal is really leaving us...what amazing presents she left us.
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Happy Hannuka to all our friends and colleagues. Wishing strength to all those facing and fighting racism in campuses overseas at this season of miracles. And a special thanks to all those protecting us.
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Good to see our latest work by Lilach Pnueli from @LabPMelamed now out in @SpringerNature journal @GeneTherapy_SN "Epigenetic repression of gonadotropin gene expression via a GnRH-mediated DNA delivery system" DOI 10.1038/s41434-022-00325-6 Details coming soon....
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Great to see latest from Ben Bar-Sadeh @BenBS8 in @BMCBiology today. "Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing" rdcu.be/cEy8l
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Check out our new paper online:
PhilippaMelamedLab@LabPMelamed14 Aug 2021
Tal's @Refael_Tal 's paper is featured this week in Endocrinology @EndoSocJournals - and is open access! academic.oup.com/endo/articl…

Enhancing Gonadotrope Gene Expression Through Regulatory lncRNAs

Abstract. The world of long non-coding RNAs (lncRNAs) has opened up massive new prospects in understanding the regulation of gene expression. Not only are

academic.oup.com
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Tal Refael retweeted
Ariel Kaplan@akaplanz3 Jul 2021
Interested in a postdoc in our lab, studying nucleosomes, transcription factors, and polymerases with cool single-molecule methods? The Fulbright postdoctoral fellowship is open for applications. fulbright.org.il/program/2/3… Please RT
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Finally! our paper on the structure and dynamics of linker histones is officially published: sciencedirect.com/science/ar… Congrats @nucleosomezky and all the authors, and thanks to @LabPMelamed for a great collaboration!
Ariel Kaplan@akaplanz11 Oct 2020
How does linker histone compact the nucleosome, at the single-molecule level? Where and how does the long C-terminal tail (CTD) of H1 bind? How does invasion by DNA-based enzymes modulate its structure? Here are some surprising findings from our new study. 1/n
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Check out our latest research on how G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome. nature.com/articles/s41467-0… @GSchotta @FCernilogar @RichterLabUnipd

Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific...

Nature Communications - G-quadruplex (G4) structures play complex roles linked to transcription regulation. Here the authors, by comparing G4 location and transcript levels in liposarcoma and...

nature.com
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Check out our new review about lncRNAs and enhancers in pituitary gonadotropes @LabPMelamed
Endocrine Society Journals@EndoSocJournals14 Jun 2021
Role of long noncoding RNAs in #pituitary gonadotrope expression: mini-review of this powerful potential approach to modifying #sexualdevelopment free to view in #Endocrinology @TheEndoSociety academic.oup.com/endo/advanc…
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Getting ready for our graduate students party! See you all at Wednesday! 🍷🎉🧀 @Ackerman_Michal @BarCo711 @AArgoetti @TechnionLive
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PhilippaMelamedLab@LabPMelamed14 Jun 2021
Tal @Refael_Tal MSc!....and staying in the lab for her PhD
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Check out our new paper online! A new model to study chromatin and gene expression regulation using primary gonadotrope cells @LabPMelamed @dor_shalev1 sciencedirect.com/science/ar…
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We’re excited to share our first "wet lab" paper published in @CellReports! Shlomi Dvir, @AArgoetti et al identified the RNA-bound proteome of human embryonic stem cells, and showed that RBPs are part of the pluripotency circuitry! 🧵! @TechnionLive cell.com/cell-reports/fullte…

Uncovering the RNA-binding protein landscape in the pluripotency network of human embryonic stem...

Dvir et al. identify the RNA-bound proteome of human embryonic stem cells and show that RNA-binding proteins (RBPs) are preferentially expressed in the pluripotent state. They reveal that RBPs are...

cell.com
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Post Shavuot lunch with the lab 🧀@LabPMelamed @dor_shalev1 @BenBS8 @nucleosomezky
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Targeting G-quadruplex Forming Sequences with Cas9 dlvr.it/RwSWcG

Targeting G-quadruplex Forming Sequences with Cas9 - PubMed

Clustered regularly interspaced palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins, particularly Cas9, have provided unprecedented control on targeting and editing specific DNA...

pubmed.ncbi.nlm.nih.gov
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Amir Argoetti@AArgoetti11 Mar 2021
אנחנו מתרגלים מצטיינים לסמסטר הקורונה הראשון, של @BiologyTechnion! @OfriLevi3 @refael_tal @Ackerman_Michal @AweidaDina
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מבצע החיסונים הגדול של הטכניון יוצא מחר לדרך! הטכניון מצטרף למאמץ הלאומי לחיסון האוכלוסייה נגד נגיף הקורונה. מחר, יום ג', יעמיד הטכניון בקמפוס יחד עם משרד הבריאות עמדות חיסונים מיוחדות של מד"א לרשות הסטודנטים, העובדים וחברי הסגל. העמדות תפעלנה בבית הסטודנט בשעות 10:00–15:00
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