Christian Rocheleau (@RocheleauLab) header
Christian Rocheleau (@RocheleauLab) profile picture

Christian Rocheleau

@RocheleauLab

We’re a research group at McGill University using the nematode C. elegans to study endocytosis and cell signaling.

 Montreal, QC
rocheleaulab.com/
Joined April 2011
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Photo by Christian Rocheleau (@RocheleauLab)
Congratulations to our collaborators, the Van Raamsdonk lab, on their new publication in Aging Cell doi.org/10.1111/acel.13762
Endosomal trafficking protein TBC‐2 modulates stress resistance and lifespan through DAF‐16‐depen...

Endosomal trafficking protein TBC‐2 modulates stress resistance and lifespan through DAF‐16‐depen...

Disruption of the endosomal trafficking protein TBC-2 alters the nuclear localization of the FOXO transcription factor DAF-16 in response to stress. This results in decreased upregulation of stress...

onlinelibrary.wiley.com
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Christian Rocheleau retweeted
Swapneeta Date, Ph.D. (@TheMolBioGal) profile picture
Swapneeta Date, Ph.D.@TheMolBioGal4 Dec 2022
We have put together an exciting series of presentations for this minisymposium. **The Art of Networking: Inter-Organelle Contacts, Movement and Homeostasis** Happening Tuesday the 6th, Room 145B #CellBio2022 #ASCB2022 #ascb #research
Image from Swapneeta Date, Ph.D. (@TheMolBioGal)
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Excited to share our latest article published in @plosgenetics: journals.plos.org/plosgeneti… #plosgeneticsauthor @solucandoktoru @VTworm @McgillU @RIMUHC1
The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan

The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan

Author summary FOXO transcription factors have been shown to modulate lifespan in multiple model organisms and to be associated with longevity in humans. Here we describe a new localization of the C....

journals.plos.org
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Abstract submission and registration are now OPEN for the C. elegans Development, Cell Biology, and Gene Expression meeting! @ElegansDev Meeting information: August 11-14, Madison WI Deadline: May 27 for abstracts to be selected for talks
Way to go Kim ⁦@thekimgauthier⁩ #ProudPI facebook.com/407526746008471…
Department of Anatomy & Cell Biology, McGill University

Department of Anatomy & Cell Biology, McGill University

📌📌Kimberly Gauthier graduated from the Anatomy and Cell Biology program in 2020. She will be talking about her doctoral journey and the transition from Ph.D. studies to post-doctoral fellowship!...

facebook.com
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Congrats to Icten Meras @solucandoktoruand others on their publication: The Rab GTPase activating protein TBC-2 extends longevity by facilitating release of FOXO/DAF-16 from endosomes biorxiv.org/content/10.1101/… #worms #RIMUHC #Celegans
The Rab GTPase activating protein TBC-2 extends longevity by facilitating release of FOXO/DAF-16...

The Rab GTPase activating protein TBC-2 extends longevity by facilitating release of FOXO/DAF-16...

FOXO transcription factors have been shown to regulate longevity in model organisms and are associated with longevity in humans. To gain insight into how FOXO functions to increase lifespan, we...

biorxiv.org
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Chapter 2 of Kim's thesis is now published in Molecular Biology of the Cell! Here she found a complex-independent role for LIN-10 in promoting basolateral localization of LET-23 EGFR. molbiolcell.org/doi/abs/10.1… @thekimgauthier @MBoCjournal @ASCBiology #Celegans #worm
LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7 |...

LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7 |...

The LIN-2/LIN-7/LIN-10 complex is necessary for Epidermal Growth Factor Receptor (EGFR) basolateral membrane localization and signaling during C. elegans vulval development. Here we found that LIN-10...

molbiolcell.org
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Check out Kim's paper in Development! The LIN-2/7/10 complex hangs out at the Golgi. dev.biologists.org/content/e… @thekimgauthier @Dev_journal #Celegans #worm
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bioRxiv viewer disq.us/t/3qmtnns
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Dynamic expression and localization of the LIN-2/7/10 protein scaffolding complex during C. elegans vulval development biorxiv.org/content/10.1101/…
Dynamic expression and localization of the LIN-2/7/10 protein scaffolding complex during C. elegans...

Dynamic expression and localization of the LIN-2/7/10 protein scaffolding complex during C. elegans...

The evolutionarily conserved LIN-2 (CASK)/LIN-7 (Lin7A-C)/LIN-10 (APBA1) complex plays an important role in regulating spatial organization of membrane proteins and signaling components. In C....

biorxiv.org
Thank you Simard lab @MartinJSimard for the festive bursting with joy worm card.
Image from Christian Rocheleau (@RocheleauLab)
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Christian Rocheleau retweeted
Terry Kubiseski 🇨🇦 (@tkubises) profile picture
Terry Kubiseski 🇨🇦@tkubises7 Sep 2018
Our preprint has been published today in @PeerJPreprints peerj.com/preprints/27176 #DevelopmentalBiology #Genetics

Caenorhabditis elegans germline development requires brap-2

Background. Mutations in C. elegans can produce visible and quantifiable defects in morphology, lifespan, and development. BRAP2/IMP (BRCA1-associated binding protein 2) has been characterized as an...

peerj.com
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⚡️ “A woman found 14 worms hiding in her eye and people are hysterical ” by @businessinsider xitter.gq/i/moments/963525503117…
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Congratulations @Sarahwazzaaa Gagnon, recipient of an RI MUHC studentship!
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End of the 2017 brag/acknowledgements. Congrats to Fiona Law PhD for her publications tandfonline.com/doi/full/10.… jcs.biologists.org/content/1… and to PhD candidate Kim Gauthier for her book chapter ncbi.nlm.nih.gov/m/pubmed/28…
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Christian Rocheleau retweeted
Christine Doronio (@scientistxtine) profile picture
Christine Doronio@scientistxtine23 Jun 2017
C. elegans MEMEatode. 😂 #worm17
Image from Christine Doronio (@scientistxtine)
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cihr-irsc.gc.ca/images/proje… Good omen, @CIHR_IRSC project review model mirrors C. elegans germ cell maturation. Hope mine is not apoptotic.
Congrats Olga, Jassy and @thekimgauthier! MBoC accepted their paper "Dynein-mediated trafficking negatively regulates LET-23 EGFR signaling"
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Best poster prize! Congrats Kim. @thekimgauthier @RocheleauLab @McGill_ACB #tgac16 appreciates worms, #CIHR not. xitter.gq/thekimgauthier/status/…
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Olga and Kim each won best poster presentations at the MUHC Cancer Axis Retreat! Woo hoo!
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