@SamesLab
Joined November 2022
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Lessons from a Toad Psychedelic about the Role of different Serotonin Receptors in Psychedelic Physiology: nature.com/articles/s41586-0… Congrats to Audrey and @LankriDavidIL in this collab with @SamesLab and @ScottRusso published in @Nature
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Wow--amazing paper from @WackerLab on #psychedelics in @nature ! Structural pharmacology and therapeutic potential of 5-methoxytryptamines nature.com/articles/s41586-0…

Structural pharmacology and therapeutic potential of 5-methoxytryptamines

Nature - Detailed analyses of the serotonin receptor 5-HT1A and the psychedelic 5-methoxy-N,N-dimethyltryptamine reveal the differences in receptor structural pharmacology that mediate signalling...

nature.com
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'The oxa-iboga compounds act as potent kappa opioid receptor agonists in vitro and in vivo exhibit atypical behavioral features compared to standard kappa psychedelics.therapeutic efficacy in addiction models and no cardiac pro-arrhythmic potential' biorxiv.org/content/10.1101/…

Novel Class of Psychedelic Iboga Alkaloids Disrupts Opioid Use

Substance use and related mental health epidemics are causing increasing suffering and death in diverse communities.[1][1],[2][2] Despite extensive efforts focused on developing pharmacotherapies for...

biorxiv.org
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I note the compounds exemplified have generally potent 5-HT2B agonist activity
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