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Jain Lab @ CCHMC

@SanjayJain_Lab

A lab of bold chemists, microbiologists, physicians, etc. pushing the boundaries of molecular imaging in infectious diseases

 Cincinnati, OH
sanjayjainlab.org/
Joined February 2020
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  • Followers467
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Photo by Jain Lab @ CCHMC (@SanjayJain_Lab)Photo by Jain Lab @ CCHMC (@SanjayJain_Lab)Photo by Jain Lab @ CCHMC (@SanjayJain_Lab)Photo by Jain Lab @ CCHMC (@SanjayJain_Lab)Photo by Jain Lab @ CCHMC (@SanjayJain_Lab)Photo by Jain Lab @ CCHMC (@SanjayJain_Lab)Photo by Jain Lab @ CCHMC (@SanjayJain_Lab)Photo by Jain Lab @ CCHMC (@SanjayJain_Lab)Photo by Jain Lab @ CCHMC (@SanjayJain_Lab)Photo by Jain Lab @ CCHMC (@SanjayJain_Lab)
🚨Our latest study identifies promising new strategies for treating TB meningitis. In preclinical models, targeted immune therapies outperformed corticosteroids. Read more: scienceblog.cincinnatichildr…
Study Points to New Strategy for TB Meningitis Care - Research Horizons

Study Points to New Strategy for TB Meningitis Care - Research Horizons

Multi-model study shows host-directed therapies reduce inflammation and outperform anti-inflammatory care in TB meningitis.

scienceblog.cincinnatichildrens.org
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💡Excited to share our latest work in @NatureComms! We identified promising host-directed therapies for TB meningitis using mouse models, human brain organoids, and patient immune cells. A step toward better treatments for this devastating disease 🔗 nature.com/articles/s41467-0…
Host-directed treatments for tuberculous meningitis utilizing a multi-platform approach across...

Host-directed treatments for tuberculous meningitis utilizing a multi-platform approach across...

Nature Communications - Here, the authors investigate a diverse panel of 12 immunomodulatory drugs as host directed treatments (HDTs) for tuberculous (TB) meningitis in a preclinical model, a human...

nature.com
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Great talk by Dr. Jan Grimm on emerging imaging modalities and the exciting potential of Cerenkov imaging. Fascinating to see how advances in molecular imaging are expanding our ability to visualize biological processes and improve diagnosis and treatment monitoring
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
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Exciting research symposium at @CincyChildrens! Great presentation by @CarlosERuizGo highlighting innovative HDTs to improving outcomes in TB meningitis, one of the most challenging forms of TB
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
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Fascinating talk today on BCG and diphtheria toxin by Drs. William Bishai and John Murphy, really exciting insights into immune responses and innovative therapeutic angles. So much potential ahead in these topics!
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
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Exciting talk today by Dr. Laurence Carroll on expanding the radiofluorination toolbox, bridging innovative methods with real-world translation in molecular imaging. A great look at how chemistry drives the future of diagnostics and beyond
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
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Today on World Tuberculosis Day, we honor the scientific breakthrough of 1882 and renew our commitment to ending TB. Prevention, diagnosis, and treatment must reach everyone, everywhere #WorldTBDay
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Great presentation and discussion today at @CincyChildrens immunology forum! Exciting to see such engagement around our work with insightful questions, thoughtful feedback, and inspiring ideas for whats next
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
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📢 New preprint on host-directed therapy for TB meningitis. Screening 12 immunomodulators across mouse models, human brain organoids, and patient PBMCs identifies candidates that reduce neuroinflammation and improve survival. 🧠🦠 researchsquare.com/article/r…

Host-directed treatments for tuberculous meningitis: A multi-platform approach across mouse and...

Tuberculous meningitis (TB meningitis) is a major cause of death and neurological deficit despite recommended antibiotic and corticosteroid treatments, primarily due to dysregulated neuroinflammati...

researchsquare.com
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📢 New paper alert! Adding clofazimine to the standard TB regimen markedly improves bactericidal activity and reduces brain inflammation in a TB meningitis model, pointing to a promising adjunctive strategy. academic.oup.com/jid/advance…
Addition of Clofazimine Enhances the Activity of Standard Treatment Regimen in a Mouse Model of...

Addition of Clofazimine Enhances the Activity of Standard Treatment Regimen in a Mouse Model of...

Clofazimine, added to standard TB therapy, reduces brain bacterial burden and inflammation in a mouse model of TB meningitis, supporting its potential as a

academic.oup.com
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🧠🦠 Our first paper of 2026 is out! This study shows why looking beyond rifampin matters for TB meningitis, highlighting rifapentine and rifabutin as promising alternatives to improve outcomes. Read here 👉🏻 doi.org/10.1093/infdis/jiag0…
Beyond Rifampin: Evaluating Rifapentine and Rifabutin as Alternative Treatments for Tuberculous...

Beyond Rifampin: Evaluating Rifapentine and Rifabutin as Alternative Treatments for Tuberculous...

Rifapentine- and rifabutin-based regimens achieved similar or superior bactericidal activity and reduced neuroinflammation compared with rifampin in a mous

academic.oup.com
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Shoutout to @XueyiChen and @MedhaSingh_18 for presenting their #TBResearch at the #IDWeek2025! One’s sharing insights via oral presentation, the other with a poster session🦠👏 Huge congrats to both on receiving the travel award!
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
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Wrapped up an incredible conference with well-deserved awards 🏆 Congratulations @CarlosERuizGo and Mona for their student travel award, and @XueyiChen for her poster select award👏
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
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Warm congratulations to Mona on delivering a compelling oral abstract presentation at #WMIC2025 👏🏻
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
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Huge congratulations to @CarlosERuizGo for delivering an excellent oral presentation at #WMIC2025. Very clearly presented and sparked great discussion. Well done! 👏
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
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Congratulations to @XueyiChen on having her poster selected for presentation at #WMIC2025! An insightful and well-delivered showcase of our research
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
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🚨 Just wrapped up an insightful talk on Molecular Imaging in Infectious Diseases at #WMIC2025! Emerging imaging tools are paving the way for faster, more accurate diagnoses and targeted treatments
Image from Jain Lab @ CCHMC (@SanjayJain_Lab)
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The Blue Journal thanks Yuderleys Masias-Leon for her contribution to the July issue Dynamic 11C–Para–Aminobenzoic Acid Positron Emission Tomography/Computed Tomography for Visualizing Pulmonary Mycobacteroides abscessus Infections @SanjayJain_Lab tinyurl.com/mbn3tzb2
Image from ATS Blue Journal (@ATSBlueEditor)
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Jain Lab @ CCHMC retweeted
SNMMI (@SNM_MI) profile picture
SNMMI@SNM_MI17 Jul 2025
New PET Tracer Identifies Diverse Invasive Mold Infections Behind Life-Threatening Illnesses in Cancer and Transplant Patients Carlos Ruiz-Gonzalez, MD jnm.snmjournals.org/content/…
Image from SNMMI (@SNM_MI)
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Dynamic 11C–Para–Aminobenzoic Acid PET/CT for Visualizing Pulmonary Mycobacteroides abscessus Infections 11C-PABA PET can differentiate M. abscessus infections from underlying pulmonary disease @SanjayJain_Lab @HopkinsKids @atscommunity 🔓 Open Access tinyurl.com/23ym8sb7
Image from ATS Blue Journal (@ATSBlueEditor)
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