@SebScheer

„Back off man, I’m a scientist.“ Epigenetic control of NK cell function @LIH_Luxembourg

 Esch-Sur-Alzette, Luxembourg
Joined January 2012
  • Tweets193
  • Following421
  • Followers265
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Replying to @Dr_HeFeng @LIH_Luxembourg @FnrLux @lcsb_uni_lu
Congrats! Well done!
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Replying to @HSudholz @Dr_Nick_Bikes
What a pleasure it was! Congrats and well done!
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Sebastian Scheer retweeted
The Scientist@TheScientistLLC9 Aug 2024
NK cells are an important anti-cancer defense, but what happens if they turn into a different cell type? A new study from @SebScheer @Dr_Nick_Bikes identified a gene without which NK cells turn into a weaker cell type, making them worse at fighting cancer. bit.ly/3SKxSCl
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Sebastian Scheer retweeted
MalmbergLab@MalmbergLab2 Jul 2024
Happy to share our new NK cell resource in @NatImmunol: "Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping." nature.com/articles/s41590-0…. @herknet, @AlinePfefferle, @AmirHorowitz @humancellatlas, @CoE_PRIMA, @UniOslo_MED
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Sebastian Scheer retweeted
Eric Vivier@EricVivier12 Jul 2024
Thrilled to announce the publication of our latest research in Nature Immunology. Joining forces with 20 laboratories in Europe and USA, we identified the three prominent NK cell subsets in human: NK1, NK2, and NK3: rdcu.be/dMuAs
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Junior Research Group Leader position: Join the Würzburg Infection and Immunology community! nature.com/naturecareers/job…

Junior Research Group Leaders - Würzburg (Stadt), Bayern (DE)

The Medical Faculty of the University of Würzburg is recruiting early career scientists as independent junior group leaders.

nature.com
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In our review article, we now assess the current literature and highlight challenges and possibilities around the "conductor" DOT1L and its immunomodulatory functions, that may pave the way for innovative therapeutic approaches. bit.ly/3z9jYmg

Frontiers | An emerging maestro of immune regulation: how DOT1L orchestrates the harmonies of the...

The immune system comprises a complex yet tightly regulated network of cells and molecules that play a critical role in protecting the body from infection an...

frontiersin.org
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...followed by @liamkealy and @KimLJacobson discovery of DOT1L's importance in B cells. bit.ly/3xrMrDl
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It started in @colbyzaph's lab in collaboration with @thesgconline, discovering that inhibition of DOT1L lead to increased IFN-γ production in CD4+ T cells (bit.ly/3Xu8ST5 and bit.ly/4ergsDX), ...

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

Nature Communications - Protein methyltransferases (PMTs) are epigenetic regulatory enzymes with significant therapeutic relevance. Here the authors describe a collection of chemical inhibitors and...

nature.com
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After our discovery of DOT1L's role in NK cells bit.ly/3XsfSQc @CellReports, we now published the cherry on top of 7 years of research on DOT1L in the immune system @MonashBDI and @LIH_Luxembourg! @JessicaRunting @DrDThiele @liamckealy bit.ly/3z9jYmg @FnrLux

DOT1L maintains NK cell phenotype and function for optimal tumor control

Sudholz et al. identify DOT1L as a key regulator of NK cell phenotype and function. DOT1L-deficient NK cells exhibit an enhanced intILC1/ILC1 phenotype, irrespective of TGF-β. Conditional DOT1L...

cell.com
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New publication from our lab 📣 cell.com/cell-reports/fullte… We demonstrate that Histone methyltransferase, DOT1L, limits NK cell conversion to ILC1s, a subset that can be observed in tumors in response to TGF-β and is correlated with poor tumor control @HSudholz @SebScheer – at Melbourne, Victoria

DOT1L maintains NK cell phenotype and function for optimal tumor control

Sudholz et al. identify DOT1L as a key regulator of NK cell phenotype and function. DOT1L-deficient NK cells exhibit an enhanced intILC1/ILC1 phenotype, irrespective of TGF-β. Conditional DOT1L...

cell.com
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Sebastian Scheer retweeted
Dr. Sophie Pilleron@SPilleron30 May 2024
🖐A new #job opening for a 2-y position as a postdoc in my team! 🔺I'm considering only applications which include responses to the 3 questions I asked in the ad ;) So, read it before applying. 🙏 Help me circulate that job offer :) lih.lu/fr/job-fr/?value=JA/P… @LIH_Luxembourg

Accueil » Luxembourg Institute of Health

Au Luxembourg Institute of Health (LIH), nous pensons que nous avons une obligation collective envers la société d'utiliser les connaissances et les technologies issues d'une recherche de qualité...

lih.lu
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Back home after a wonderful meeting of Functional Epigenomics in Saarbrücken. Going back to @LIH_Luxembourg with many new inspirations and the excitement that understanding and exploiting epigenetic mechanisms in immune cells will be key to solve many problems in the clinic.
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Replying to @colbyzaph
Big congrats to these exceptional students! However, also a big „well done“ to the PhD „dad“.
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Sebastian Scheer retweeted
Nature Immunology@NatImmunol11 Jan 2024
Huntington and colleagues describe the functions of Ikaros and Aiolos in NK cell development. Read it here: rdcu.be/dvLeC nature.com/articles/s41590-0…
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What Harry says. Well done, team!
Harrison Sudholz@HSudholz5 Jan 2024
Excited to have our paper out in @NatImmunol IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development nature.com/articles/s41590-0…
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Sebastian Scheer retweeted
Qi Zhang@QiZhang8528 Sep 2023
I am hiring, please RT🙏🙏 POSTDOC: a molecular biologist to study the mechanism of chromatin modifiers in gene repression. careers.adelaide.edu.au/cw/e… RA & LAB MANAGER: a protein biochemist & to lead the laboratory operations within a brand-new lab. careers.adelaide.edu.au/cw/e…
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En route to #nk2023!
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Welcome to the @IEE_Research_Gp team, May Wantz! May will work on the epigenetic regulation of NK cell function as part of our @FnrLux and @FondationCancer funded EPICON project @LIH_Luxembourg. May you do well! 😉
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A @MonashBDI study has found that a protective immune feature may be lacking in people with chronic infections caused by parasitic worms, which can help lead to improved #treatments and human vaccines. @MonashCCS #globalhealth Read it on @MucosalImmunol: pubmed.ncbi.nlm.nih.gov/3739…

Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the...

T follicular helper (Tfh) cells are an important component of germinal center (GC)-mediated humoral immunity. Yet, how a chronic type 1 versus protective type 2 helminth infection modulates Tfh-GC...

pubmed.ncbi.nlm.nih.gov
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