Sheldon L. Holder (@SheldonLHolder) header
Sheldon L. Holder (@SheldonLHolder) profile picture

Assistant Professor of Pathology and Laboratory Medicine | Medical Oncologist | Physician Scientist

Joined March 2012
Photo by Sheldon L. Holder (@SheldonLHolder)Photo by Sheldon L. Holder (@SheldonLHolder)Photo by Sheldon L. Holder (@SheldonLHolder)Photo by Sheldon L. Holder (@SheldonLHolder)Photo by Sheldon L. Holder (@SheldonLHolder)Photo by Sheldon L. Holder (@SheldonLHolder)Photo by Sheldon L. Holder (@SheldonLHolder)Photo by Sheldon L. Holder (@SheldonLHolder)Photo by Sheldon L. Holder (@SheldonLHolder)Photo by Sheldon L. Holder (@SheldonLHolder)
Sheldon L. Holder retweeted
Why does diversity in genetic research matter? Because it ensures equitable health outcomes for communities like ours in the Caribbean. Genetic research shapes everything from prevention to treatment, and we need to make sure no one is left behind. #HealthEquity #CaribbeanScience
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A photograph of Malcolm X's mother, Louise Norton Little (1897-1989). Louise Little was a brilliant woman, speaking multiple languages, and for years, along with her husband Earl Little, a dedicated activist of Marcus Garvey's Pan-African Movement (Universal Negro Improvement Association and African Communities League). Louise Norton Little (1897-1989) was a Grenadian-born American activist and the mother of Malcolm X. Here are some key facts about her life. - Born in Grenada to a former slave from Nigeria and a Scotsman - Raised by her grandparents in Grenada - Immigrated to Canada in 1917 and joined the UNIA (Universal Negro Improvement Association) - Met her husband Earl Little at a UNIA meeting in Montreal and married in 1919 - Had eight children with Earl, including Malcolm X - Was a Garveyite activist who taught her children about black pride and self-reliance - Was committed to a mental institution for 24 years and released in 1963 with the help of her children - Lived with her family in Grand Rapids, Michigan, until her death in 1991 at the age of 94
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4 years before Rosa Parks ignited the Montgomery Bus boycott by refusing to give up her seat in Alabama, there was PFC Sarah Keys from the Keyesville neighborhood of Washington, NC, who when traveling from Fort Dix in NJ back home to Washington, NC on August 1, 1951, was told to relinquish her seat to a white Marine and move to the back of the bus. Keys refused to move, thus the driver emptied the bus, directed the other passengers to another vehicle, and barred Keys from boarding it. When Keys asked why she shouldn’t ride the bus, she was arrested and spent 13 hours in a cell. Keys was eventually ordered to pay a $25 fine for disorderly conduct, was released, and put on a bus to her hometown. Her case was brought before the Interstate Commerce Commission with Dovey Johnson Roundtree as her lawyer and wasn’t settled until 1955. In Sarah Keys v. Carolina Coach Company, the ICC favored Keys, ruling the Interstate Commerce Act forbids segregation.
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Great presentation by @BrownUPathoGP student Kimberly Meza @ksmeza about modulation of TRAIL death receptor DR5 in liver cancer through ASB3
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Great presentation by @BrownUPathoGP PhD student Kim Meza @ksmeza, member of @SheldonLHolder lab #HolderLab at #LegorretaCancerCenter @BrownUCancer @BrownMedicine on collaborative studies with our #eldeirylab on targeting PIM1 kinase to sensitize RCC to TRAIL agonists. This could evolve as a future therapy for RCC.
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Thankful to our #LegorretaCancerCenter administration and leaders for all the hard work of preparation and presentations to our EAB today. Also grateful for all the feedback we received from our advisors. Our work is intensifying as we strive for impact on our community and region. @BrownUCancer @BrownMedicine @BrownUniversity @ShiOnaCo @RoyJensenMD @DrPhilKantoff @weinerg @MarianaStern @Dr_R_Kurzrock @rwsobol @drdonsdizon @bcarneiro7 @LiangChengMD @SenduraiMani @CaraMath @Roxanne344 @insarkar @DrSGraff @SheldonLHolder @DawsonStemCell @slibutti @DrRobWinn @DrJoannSweasy @LeonidasPlatan1 @LauraStroudPhD
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On this day in 1835, a mob of white citizens and a hundred yoke of oxen pulled a Black school to a swamp outside the town of Canaan, New Hampshire and fired cannons to the boarding homes of the black students. —On August 10, 1835, nearly 500 white men destroyed the Noyes Academy in Canaan, New Hampshire, using 100 oxen to pull the schoolhouse off its foundation and drag it a mile down the road. Noyes Academy was a new integrated school (the second in the country) founded by abolitionists with 28 white and 14 Black students. The African American students, who came from all over the Northeast, traveled long distances in the face of adversity to get to the school. Students included future leaders of note such as Henry Highland Garnet and Alexander Crummell. Noyes Academy was a new integrated school (the second in the country) founded by abolitionists. The African American students, who came from all over the Northeast, traveled long distances in the face of adversity to get to the school. Students included future leaders of note such as Henry Highland Garnet and Alexander Crummell. After destroying the school, the mob fired cannons into the homes where the African American students were boarding and threatened the students. Shots were exchanged which created a distraction for the Black students to escape out of town. Despite attempts to repair and reopen the school, the structure was burnt to the ground three years later.
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Great strategic research planning session with scientific and clinical leaders at #LegorretaCancerCenter at @BrownUniversity @BrownMedicine @BrownUCancer @BrownUnivHealth @carenewengland @HasbroChildrens There is something magical and that is great to see when a senior leadership group works intensively together for many months to shape a future vision at a place like Brown University. It takes a special group to work cohesively together across disciplines with a common mission and vision. Honored to facilitate the pursuit of research excellence to serve our communities in Rhode Island and beyond. Research and innovation bring hope for better days with less burden from cancer here and elsewhere. @ShiOnaCo @rwsobol @bcarneiro7 @LiangChengMD @insarkar @SeanLawler20 @DawsonStemCell @drdonsdizon @CaraMath @SheldonLHolder @Roxanne344 @SenduraiMani @DrSGraff @LauraStroudPhD
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Great to have physician-scientist and thoracic medical oncologist Dr. Tao Zou @TaoZou2 visiting the #LegorretaCancerCenter @BrownUCancer from @DanaFarber @BrighamWomens to speak about innate immune sensing pathways as cancer therapeutic targets. @ShiOnaCo @bcarneiro7 @JerryAzzoli @HinaKhanMD @rwsobol @SenduraiMani @SheldonLHolder @DawsonStemCell @drdonsdizon @DrSGraff @BrownMedicine @BrownUniversity @LifespanHlthSys
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BioQuest just completed the reference genome of the Grooved Brain Coral in Bermuda, marking a Caribbean first! 🧬🇧🇲 This groundbreaking achievement was made possible through collaboration with #CariGenetics #BioQuest #MarineConservation #BermudaScience
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Exciting @BrownOncology updates at @BrownMedicine @BrownUCancer @LifespanHlthSys @carenewengland Investigator-initiated cancer clinical trials with unique approaches and science in our region to offer precious therapeutic options right here in Rhode Island. @SheldonLHolder @WilliamSikov @bcarneiro7 @Roxanne344 @drdonsdizon @DrSGraff @lymphomatic @myelomatic @LiangChengMD @ShiOnaCo @rwsobol @SenduraiMani @Attila_Seyhan
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Summary report for ReclaimAI. It helps to automatically manage meetings on my calendar. I'm pretty sure I did NOT eat 4 lunches on Tuesday. 15h of meetings is a 21% decrease over last week 😳!! It does feel like I met with 391 people! @weldeiry @drdonsdizon @BrownUCancer
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📣 It’s your turn men 💙 Please share far and wide within your networks 🙌🏾 To join, please register here: forms.gle/rxnDnGt5wHJ1pgJZ6 @DrRobWinn @weldeiry @brian_rini @DrChoueiri @jonmakUrology @DrRosenbergMSK @Uromigos @montypal @VivekSubbiah @CariGenetics @CarikaElshae 🇧🇲
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We enjoyed very much hosting @AmericanCancer Delegation at the #LegorretaCancerCenter @BrownUCancer including @CMAnnunziata @The_Ryan_Strik Bill Sherman, Paul Hull, Courtney Needham and Marc Hymovitz @ACSCAN @ACSCANRI He had meetings with our senior leaders, students and other trainees, and we hard from the inaugural group of ACS-IRG awardees at @BrownUniversity Deepraj Ghosh, Ying Ma and Theresa Raimondo. We toured some lab facilities and had lunch before the delegation headed out to the RI Statehouse. There were great questions asked and information exchanged including with trainees looking for career development, volunteer opportunities and advocacy roles. We are very grateful to the ACS for supporting cancer research in Rhode Island and for patient advocacy. @ShiOnaCo @rwsobol @Attila_Seyhan @SenduraiMani @drdonsdizon @DrSGraff @LiangChengMD @SheldonLHolder @LanlanZhou @shengliang15 @bcarneiro7 @SeanLawler20 Pat Dubielecka, Jeremy Warner @BrownMedicine
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For Black men, #prostatecancer risk increases at younger ages compared to other groups as outlined in this graph. This suggests a need for earlier screening in this population Learn more about the new PCF Guidelines: tinyurl.com/4jhr5m8j 📷: NEJM Evid 2024; 3 (5)
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New evidence-based PCF Prostate Cancer Screening Guidelines for Black Men in the U.S. recommend that Black men consider PSA screening between ages 40-45, and screen annually depending on PSA levels and health status. 🧵⬇️
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