Sinan Shi (@ShiSinan) profile picture

Sinan Shi

@ShiSinan
 Oxford, England
Joined May 2012
  • Tweets26
  • Following225
  • Followers97
Sinan Shi retweeted
Sile Hu (@fuopen) profile picture
Sile Hu@fuopen3 Feb 2025
Excited to see my project at @UniofOxford finally published at @NatureGenet ! Huge thanks to my co-authors @simon_r_myers @danjlawson @marchini @g_hellenthal @linoafferreira @ShiSinan , and the reviewers/editors. Read the publication here: nature.com/articles/s41588-0… 🚀🎉
Fine-scale population structure and widespread conservation of genetic effect sizes between human...

Fine-scale population structure and widespread conservation of genetic effect sizes between human...

Nature Genetics - This study introduces the concept of Ancestry Components and shows that they can offer improved population stratification correction for geographically correlated traits. By using...

nature.com
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Happy New Year! Our Twigstats paper is now out! nature.com/articles/s41586-0…
High-resolution genomic history of early medieval Europe

High-resolution genomic history of early medieval Europe

Nature - Twigstats, a method for ancestry reconstruction, provides high-resolution genetic histories and movement patterns of people living in Europe during the first millennium ce.

nature.com
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Fast variance component analysis using large-scale ancestral recombination graphs biorxiv.org/cgi/content/shor… #biorxiv_genetic
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On behalf of @zilongli21 , @A_Albrechtsen and myself, I’m pleased to announce the release of QUILT2, a method for lc-WGS imputation using biobank scale reference panels that works on diverse sequencing input data including NIPT data. biorxiv.org/content/10.1101/…
Rapid and accurate genotype imputation from low coverage short read, long read, and cell free DNA...

Rapid and accurate genotype imputation from low coverage short read, long read, and cell free DNA...

Inexpensive and accurate genotyping methods are essential to modern genomics and health risk prediction. Here we introduce QUILT2, a scalable method for genotype imputation using low-coverage...

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Many thanks to all the collaborators, and especially to @simon_r_myers and @marchini who led this project!
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Our paper on the GEL haplotype reference panel and the latest whole-genome imputed #ukbiobank data (21008) is out #NatureGenetics, implying rare non-coding mutations are not as disruptive as coding variants. nature.com/articles/s41588-0…
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Replying to @marchini @privefl @anderson_carl @alyssa_clay @LeGuenYann @josep_mercader @uk_biobank @FachalLaura
Imputation from the Genomics England WGS data is also available biobank.ndph.ox.ac.uk/showca… and GBR samples (the majority of UKB) and SAS samples looks better than TOPMed
Image from Jonathan Marchini (@marchini)
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Very interesting new method describing genealogy-based association that detects more rare and ultra-rare signals than imputation.
Brian Zhang (@brianczhang) profile pictureBrian Zhang@brianczhang4 Nov 2021
Excited to share our bioRxiv preprint on genealogical inference and genealogy-based mixed model analysis in the UK Biobank! biorxiv.org/content/10.1101/… For a summary of this work, see our ASHG 2021 talk (session 017). Joint work with @aabiddanda and Pier Palamara.
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This is one you can share with your budding scientists! Hope to see a surge in population geneticists in a few years... Great pleasure to write this with @bycgen and huge thanks to Megan Myers (and @simon_r_myers) and our young reviewers! kids.frontiersin.org/article…
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Pier Palamara's research group at @OxfordStats and @HumanGeneticsOx is recruiting two ERC/NIH-funded postdoctoral research associates. Statistics and machine learning for large-scale genomic data, population genetics, complex traits. Details and contacts: my.corehr.com/pls/uoxrecruit…
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A high-resolution map of non-crossover events in mice reveals impacts of genetic diversity on meiotic recombination biorxiv.org/cgi/content/shor… #bioRxiv
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The UK Biobank genetic data paper is published today in Nature nature.com/articles/s41586-0… @uk_biobank @nature @bycgen

The UK Biobank resource with deep phenotyping and genomic data

Nature - Deep phenotype and genome-wide genetic data from 500,000 individuals from the UK Biobank, describing population structure and relatedness in the cohort, and imputation to increase the...

nature.com
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Our work on the genetics of brain imaging also published in Nature today nature.com/articles/s41586-0… Big thanks to all involved : Lloyd Elliott (sfu.ca/~lloyde/) @KevinJSharp @NeuroFidelity @ShiSinan Gwen Douaud @fmrib_karla Steve Smith @uk_biobank
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The DNA of people in Spain today tell the story of a turbulent mediaeval past. We find extensive fine-scale population structure in Spain, and clear effects of historical migration from North Africa. Galicia has its own surprises too. xitter.gq/biorxivpreprint/status…
bioRxiv (@biorxivpreprint) profile picturebioRxiv@biorxivpreprint13 Mar 2018
Patterns of genetic differentiation and the footprints of historical migrations in the Iberian Peninsula biorxiv.org/cgi/content/shor… #bioRxiv
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Oxford BIG Browser v2 released big.stats.ox.ac.uk with 5,694 GWAS. We've added the Neale group GWAS results + others, and now report effect sizes for SNPs @OxfordStats @FMRIB @uk_biobank @bmneale
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