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sweiler

@SimonWeiler3

Systemic Neuroscientist- interhemispheric communication- Layer 6- multimodal integration- bird brain atlas- runner

 London, England
sites.google.com/view/neuroweiler
Joined May 2018
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  • Followers279
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Photo by sweiler (@SimonWeiler3)Photo by sweiler (@SimonWeiler3)Photo by sweiler (@SimonWeiler3)Photo by sweiler (@SimonWeiler3)Photo by sweiler (@SimonWeiler3)Photo by sweiler (@SimonWeiler3)Photo by sweiler (@SimonWeiler3)Photo by sweiler (@SimonWeiler3)Photo by sweiler (@SimonWeiler3)Photo by sweiler (@SimonWeiler3)
Preprint alert: Interested in the intra and interhemispheric anatomical hierarchical organization of the neocortex? See our new study @SWC_Neuro together with @TeichertManuel @UKJ_Jena & Troy Margrie, online now + 🧵: biorxiv.org/content/10.1101/…
Layer 6 corticocortical cells dominate the anatomical organization of intra and interhemispheric...

Layer 6 corticocortical cells dominate the anatomical organization of intra and interhemispheric...

Cortico-cortical projection neurons couple functionally distinct areas within and between the cortical hemi-spheres via feedback and feedforward pathways that originate from different cortical...

biorxiv.org
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We have created the first open-source high-resolution bird brain atlas of a migratory & magnetoreceptive species (Eurasian blackcap). 🐦‍⬛🧭🧲 Please see the paper: cell.com/current-biology/ful… Please see the news: sainsburywellcome.org/resear… Please see 🧵👇
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5/6 We identified a pathway linking the magnetosensitive area Cluster N to the NCL (prefrontal cortex)
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6/6 Thanks everyone involved. I am deeply grateful for this amazing collaboration. Onto the next brain atlas!
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SWC (@SWC_Neuro) profile picture
SWC@SWC_Neuro14 Nov 2025
Will you be at #SfN25? Stop by the Sainsbury Wellcome Centre’s posters and talks! @SfNtweets
Image from SWC (@SWC_Neuro)
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Please come and see my poster at #Sfn2025 on how layer 6 callosal projection neurons modulate visual processing and convey ipsilateral eye responses in the monocular part of the visual cortex. Session Number: PSTR072 Sunday 16th November, 8 am - 12 pm
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In @eLife: Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedback doi.org/10.7554/eLife.100478
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Please see our manuscript on a digital 3D bird brain atlas of a migratory and magnetoreceptive species (Eurasian blackcap) online now 🐦‍⬛🧭🧠: biorxiv.org/content/10.1101/… See also short thread👇
Mapping the magnetoreceptive brain: A 3D digital atlas of the migratory bird Eurasian blackcap...

Mapping the magnetoreceptive brain: A 3D digital atlas of the migratory bird Eurasian blackcap...

Birds undisputedly range amongst nature’s foremost navigators. To successfully navigate between breeding and wintering quarters, they, in addition to other natural orientation cues, rely on their...

biorxiv.org
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2/3 The atlas is accessible via the standardized BrainGlobe Atlas API: brainglobe.info/blackcap This allows the community to directly align their own experimental multimodal data to the common coordinate space of the atlas, see example:
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3/3 Thanks to a fun collaboration between the @SWC_Neuro , @swc_niu and the Animal Navigation group at the University of Oldenburg (my hometown)
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How do individual neurons distinguish internal from external motion ? Please see this amazing study by my colleagues at Troy Margrie lab @SWC_Neuro sciencedirect.com/science/ar…
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Our study on how to overcome off-target optical stimulation-evoked cortical activity in the mouse brain in vivo is now peer-reviewed published, please see: cell.com/iscience/fulltext/S…
Overcoming off-target optical stimulation-evoked cortical activity in the mouse brain in vivo

Overcoming off-target optical stimulation-evoked cortical activity in the mouse brain in vivo

Natural sciences; Biological sciences; Neuroscience; Systems neuroscience; Techniques in neuroscience

cell.com
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Are you working with in vivo optogenetics? Ever wondered what the impact of shining laser light within the brain in the absence of exogenous opsins has on neuronal activity? PLEASE SEE biorxiv.org/content/10.1101/… & READ 🧵👇 work done @SWC_Neuro, thx Mateo Velez-Fort & Troy Margrie
Overcoming off-target optical stimulation-evoked cortical activity in the mouse brain in vivo

Overcoming off-target optical stimulation-evoked cortical activity in the mouse brain in vivo

Genetic engineering of exogenous opsins sensitive to a wide range of lightwavelengths allows the interrogation of brain circuits to an unprecedented temporal and spatial precision. In particular,...

biorxiv.org
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4/5 So please consider factors such as the duration, intensity and wavelength, the fiber implantation site and the proximity of both the stimulation and recording site to the eyes and visual pathway in your experiment
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5/5 Please also see this study which shows that this off-target activation can impact behaviour: journals.plos.org/plosone/ar…

Optogenetics in Mice Performing a Visual Discrimination Task: Measurement and Suppression of...

Optogenetic techniques are used widely to perturb and interrogate neural circuits in behaving animals, but illumination can have additional effects, such as the activation of endogenous opsins in the...

journals.plos.org
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