Stojdl Lab

The @StojdlLab has now moved from working in an academic space to an industrial one. This gives us a strong translational platform to get our #oncolytic immunotherapies to the #cancer patients who need them. Visit turnstonebio.com to track our progress. #immunotherapy

Can the site of metastasis predict treatment outcomes in #cancer patients treated with #immunotherapy ? mdpi.com/2076-393X/8/2/203 Interesting #OA #research from @MDPIOpenAccess @SapienzaRoma Image credit: Botticelli et al. 2020 #openaccess #metastasis

Prime/boost treatment of #HIV patients with Ad26/Vaccinia #virus #vaccines generates robust #immune responses but only delays time to viral rebound for several days compared to placebo: go.nature.com/3eAY6RP via @NatureMedicine #immunology #vaccination #publichealth

Nice @Cancer_Cell review of intratumoural #heterogeneity, including its sources, ways to capture and account for it during clinical decision making, and potential strategies to improve therapeutic outcomes by directly targeting it: bit.ly/2XS9ItU #cancer #immunotherapy

Great @CellCellPress perspective piece describing the Human Tumour Atlas Network (HTAN), which will chart tumour transitions across space and time at the single-cell level bit.ly/3boK1Fh via @broadinstitute #cancer #immunotherapy #OA #dataviz Image: Rozenblatt-Rosen 2020

Visualising T cell migration in the spleen reveals a network of perivascular pathways that guide entry into T zones: bit.ly/2RSCoiN via @ImmunityCP @UniofOxford #OA #immunology #immunity Image credit: Chauveau et al. 2020

Sequencing of serially passaged #oncolytic measles #virus demonstrates genomic stability and a robust safety profile for clinical applications: bit.ly/2SWWUzI via @MicrobioSoc @DKFZ @OttawaHospital Image credit: @CDCgov

Interesting model describes how spatial structures, such as solid tissues and diffusion liquids, may impact the ability of viruses to avoid innate #immunity during #infection: bit.ly/2SU2jpF via @PLOS @CSIC #virus #virology #OA Image credit: Segredo-Otero & Sanjuán 2020

Long-term responses to PD-1 #immune checkpoint blockade are associated with stroma remodeling and reduced expression of tumour cell proliferation markers in mice & patients w/ skin #cancer go.nature.com/2P0NdxH via @NatureComms @OfficialUoM #immunotherapy #OA Image Galvani 2020

Nice @jitcancer review of T cell-targeted #immune checkpoint inhibitor therapies in brain #cancer - where we are, and how we can achieve clinically meaningful benefits: bit.ly/2vIU6gs via @theNCI #OA #openaccess #immunotherapy #immunecheckpoint #glioma

Exciting new @SpringerNature protocol book chapter on #oncolytic viruses, with a great focus on the immunotherapeutic effects of oncolysis, immunomodulation and immunomonitoring: bit.ly/2u9oakS H/T @DKFZ #virus #cancer #immunotherapy #virology #immunology #immunity

Interesting review of the tools, methods & trends for the visual analysis of #cancer-related #genomic #data, and the serious challenges that still need to be overcome to derive clinical meaning from big datasets bit.ly/2Hsb9pA #OA #bigdata #datavisualisation Image Qu2019

Say it with #Histology this #ValentinesDay❤️ . . . . All images credited to @IHeartHisto . #love #science

More #evidence suggesting that the use of #antibiotics within two months of starting #immune checkpoint inhibitor #immunotherapy may have a deleterious effect in patients with advanced #cancer: bit.ly/2HbNkC8 via @SpringerNature @UniBasel @UniSpitalBasel @Unispital_USZ

Genome-wide CRISPR-Cas9 screening finds a HLA-independent T cell receptor that targets #cancer vs. non-cancer cells via the MHC class I-related protein, MR1, based on sensing the cancer #metabolome: go.nature.com/2SdwRDN via @NatImmunol @cardiffuni @UofUMedicine #immunotherapy

New automated flow peptide synthesis technology produces 30-mer #neoantigen peptides in less than 35 minutes and 16-mers in less than 20 for personalised #cancer #immunotherapy: go.nature.com/2H7f9M3 via @SciReports @MIT @broadinstitute @kochinstitute #OA Image: Truex 2020

Genetically stable poliovirus vectors activate dendritic cells and prime anti-tumour CD8+ T cell #immunity in mice: go.nature.com/2GRr0xu via @NatureComms @DukeU @UCSF #cancer #immunotherapy #oncolytic #virus #PVSRIPO #OA #openaccess Image credit: Mosaheb et al. 2020

Directing traffic: how to effectively drive T cells into tumours. Nice mini-review from @CD_AACR @DanaFarber @harvardmed @broadinstitute @BrighamResearch @AACR Image credit: Anandappa et al. 2020 #cancer #immunotherapy #combinationtherapy