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A #Russia's missile hits the building while a Ukrainian volunteer is asking for more help.
#Ukraine #UkraineInvasion
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Remarkable moment caught on camera as Zelensky hears about the bombing of the Babyn Yar Holocaust memorial for the first time.
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so apparently Zelenskyy won the Ukrainian version of Dancing with the Stars in 2006 and the tape is even better than whatever you're imagining
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9/ We have loved working on this and learnt so much. Thank you to the amazing Nick Williams! To all the team, Joe Lee, @luiza_moore, Anna Godfrey. To Peter Campbell and Tony Green. Our funders @CR_UK @mpnrf @EHA_Hematology and our dear patients.
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8/ Importantly, the rate of expansion of mutant-JAK2 predicted the time to MPN diagnosis..... a possibility of early detection and disease prediction? #stopcancer
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7/ Clone growth rates varied: <10%/yr to >200%/yr for multiply mutated clones. #JAK2V617F clones grew at different rates in different individuals - ie patient-specific factors (germline, environment) influence its consequences as shown by @bloodgenes lab and others.
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6/ Cancer driver mutations could occur sequentially - decades apart. Different orders including JAK2 mutations coming second. #clonalevolution
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5/ We found in utero and childhood acquisition of DNMT3A mutations too. In one patient, the #DNMT3A mutation was acquired within few weeks of conception – the start of life. Ageing per se didn’t drive such clonal haematopoiesis – it simply took an age for the clones to grow.
ALT DNMT3a mutation very early post conception. Complex clonal structure and multiple cancer associated mutations.
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4/ JAK2 mutations were acquired early in life - in utero and childhood despite a diagnosis many decades later, up to 54 years before MPN diagnosis for one patient #JAK2V617F
ALT Family tree of blood production. Showing normal and JAK2 mutant descendant lines
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3/ We used DNA mutations to trace the ancestral relationships between colonies - building a "family tree" of blood production for each patient. We could then time the cancer driving genetic events and trace how the mutant clones expanded over the patient’s life.
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2/ We took single blood cells from patients with MPN and grew each cell into a colony. We then sequenced each colony's whole genome (>950 whole genomes).
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1/ "How long have I had it for?"
Our patients with #bloodcancer have always wanted to know. We set out to answer it. We studied patients with MPN #mpnsm and found quite unexpected results. Excited to share our preprint biorxiv.org/content/10.1101/…
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@JimmyDoreShow devotes a full episode youtu.be/0HVapwIrdhE?t=585 to #masks4all following @jeremyphoward's tweetstorm. From 9:45 to 12:20 @jimmy_dore presents our #UniversalMasking work at dek.ai/masks4all by @dekai123 @guypgoldstein @AlexeyMorgunov @V_alien @AnnaRotkirch
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@nytimes interviews me on harmful culturally-driven unconscious biases against #UniversalMasking, and our work that "has modeled the potential for mass mask-wearing to significantly reduce infections" by @dekai123 @guypgoldstein @AlexeyMorgunov @V_alien @AnnaRotkirch #masks4all
6/Still, even if it may be possible to establish only correlation, not causation, said @dekai123, “if the downside is nothing, and the upside is huge, then you take the bet” and wear a mask nyti.ms/2Y6Df1n
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🔐Use of in situ simulation to evaluate the operational readiness of a high‐consequence infectious disease intensive care unit.
This excellent paper from @TajFregene, @jambuc33 and @v_alien is #FOAMed forever!
🔗onlinelibrary.wiley.com/doi/…
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🔐"The problems identified encompassed aspects of operational readiness of the ICU for admission of patients with COVID‐19. These included staff preparedness, equipment shortages and lack of tailored guidelines."
@TajFregene @jambuc33
@v_alien
🔗onlinelibrary.wiley.com/doi/…
V_alien retweeted
🔐This new in situ simulation study from @TajFregene, @jambuc33 and @v_alien shows how multiple operational deficiencies were found and corrected before the admission of the first patient with COVID-19 at high-consequence infectious disease ICU.
🔗onlinelibrary.wiley.com/doi/…
