@WinzelerLabUCSD

Official account of Prof. Elizabeth Winzeler's Lab at UC San Diego | Drug discovery, target ID, resistance mechanisms, and host-pathogen interactions of malaria

 San Diego, CA
winzeler.ucsd.edu/
Joined December 2018
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9Media
Out today in @CellChemBiol: genetic and chemical validation of PfAcAS as a druggable antimalarial target. Congratulations to all MalDA members on this colossal effort advancing #drugdiscovery in #malaria! sciencedirect.com/science/ar…
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Many #womeninmalaria at the fore front of #MalDA, Accelerating Malaria Drug Discovery @TrendsParasitol @WinzelerLabUCSD sciencedirect.com/science/ar…
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New review out now! Find out who we are and what we do in #malaria drug discovery: sciencedirect.com/science/ar…
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SnapShot: Antimalarial Drugs - @madelineluth @elizabethwinze1 @cellcellpress hubs.ly/H0y98Bh0
SnapShot: Antimalarial Drugs

ALT SnapShot: Antimalarial Drugs

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Excited for the start of #MPM2020! Congratulations to all of the presenters, which include multiple Malaria Drug Accelerator members.
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Genomic Approaches to Drug Resistance in #Malaria by Frances Rocamora @WinzelerLabUCSD in @AnnualReviews annualreviews.org/doi/abs/10…

Genomic Approaches to Drug Resistance in Malaria

Although the last two decades have seen a substantial decline in malaria incidence and mortality due to the use of insecticide-treated bed nets and artemisinin combination therapy, the threat of drug...

annualreviews.org
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Great work by several MalDA members and collaborators showing that a rapamycin analog targets #Plasmodium FKBP35. Out now in @ACSMedChemLett! pubs.acs.org/doi/10.1021/acs…

Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35

Abstract. FK506-binding protein 35, FKBP35, has been implicated as an essential malarial enzyme. Rapamycin and FK506 exhibit antiplasmodium activity in cul

pubs.acs.org
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Winzeler Lab retweeted
ACMCIP@acmcip13 Jul 2020
Calling all parasitology trainees! @acmcip is running a free workshop titled “Science Communication in the Time of COVID19” on Thursday, July 23 at 4pm EDT (GMT-4). Register here: docs.google.com/forms/d/e/1F…. #ACMCIPtrainees
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Check out our latest collaboration with @WinzelerLabUCSD @ElizabethWinze1 and @afcowman!
Nature Communications@NatureComms27 Apr 2020
Imidazolopiperazine compounds are under clinical development for #malaria. Here the authors show that the compounds inhibit the parasite's secretory pathway, affecting protein trafficking & export @WinzelerLabUCSD @fidocklab @ElizabethWinze1 @afcowman go.nature.com/2Yg4hoC
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Imidazolopiperazine compounds are under clinical development for #malaria. Here the authors show that the compounds inhibit the parasite's secretory pathway, affecting protein trafficking & export @WinzelerLabUCSD @fidocklab @ElizabethWinze1 @afcowman go.nature.com/2Yg4hoC
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#Postdoc opp to work with me & my team @UCSDMedSchool on a study of injection drug use, cross-border mobility & drug markets related to #HIV & #HCV. Must be eligible for a #T32 slot from NIH. Spanish language an asset. #publichealth #epiTwitter #borderhealth #harmreduction
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The CDC-provided COVID-19 primers have potential issues with hairpins and dimerization, writes @tomeraltman. In his new blog post, he designs better candidate primers to help develop better diagnostic kits. Please RT. #COVID19 #COVID_19 #Coronavirus tomeraltman.net/2020/03/03/t…

Technical Problems with Existing CDC COVID-19 Primers, and an Improved Set of Primers

Summary

tomeraltman.net
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Congratulations to MalDA member Ian Gilbert on this wonderful accomplishment!
WCAIR Univ of Dundee@WCAIRDundee3 Mar 2020
Congratulations Prof Ian Gilbert, Head Medicinal Chemistry @DDU_Dundee #BCDD @UoDLifeSciences.Elected Fellow Royal Society Edinburgh @news_RSE for outstanding research #drugdiscovery #beatNTDS #malariamustdie. Read more buff.ly/3awItID @MedsforMalaria @DNDi @wellcometrust
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Great section on Drug Development @MAMLorne thanks to @parasite_doc @ElizabethWinze1 @afcowman @tobinatthelab @WEHI_research @MonashUni @MSDInvents @Merck #MAM2020
Freya Fowkes@FreyaFowkes24 Feb 2020
So many promising new antimalarials showcased in the #MAM2020 drug development session sponsored by @MonashUni
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Winzeler Lab retweeted
ASM@AUSSOCMIC24 Feb 2020
@ElizabethWinze1 kicks off day 3 and the drug development session by telling us about stories from the Malaria Drug Accelerator (MalDA), a multinational drug discovery program funded by @gatesfoundation #MAM2020 – at Lorne, Victoria
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A great talk on next-generation medicines for malaria by @ElizabethWinze1 from University of California in the drug development session #MAM2020
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Probing the Open Global Health Chemical Diversity Library for multistage-active starting points for next-generation antimalarials. dlvr.it/RQVmqC

Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for...

Most phenotypic screens aiming to discover new antimalarial chemotypes begin with low cost, high-throughput tests against the asexual blood stage (ABS) of the malaria parasite life cycle. Compounds...

pubmed.ncbi.nlm.nih.gov
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The #WomenInMalaria community wish you a Merry Christmas ​gph.is/g/E0loDy8
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On 18 December 1897 Ronald Ross published his paper linking mosquitos and malaria transmission, that he had originally recorded in this notebook. "The work, was most exhausting, and so blinding that I could scarcely see afterwards," he said.
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The US budget under consideration has a proposed 17% cut to research #funding @NIH which is ~$6 BILLION, after years of flatlined support (which were essentially cuts since they did not keep up with inflation). Time to advocate NOW! Support #science! Call your representatives!
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