
Epidemiologist Postdoc @Penn with @damrauer PhD & MPH @karolinskainst | BM @WuHanUniv He/him/his. Views are my own.
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ALT The image is an infographic titled "The Gain-of-Function GLP1R131Q Variant Preserves β-Cell Function and Enhances Response to GLP-1 Receptor Agonists." It contains several sections with diagrams and charts. The left section discusses the GLP1R131Q variant with its location represented on a chromosome illustration. The middle section features a diagram of the gain-of-function signaling pathway, showing interactions involving cAMP and β-arrestin. The right section contains two graphs: one illustrating insulin secretion in response to GLP-1RA treatment, and another showing improved HbA1c levels and a detailed receptor response. The text notes that the variant is common in East Asians (MAF ~21%). The infographic suggests that GLP1R131Q could be important for diabetes care.




















