Credit to the trialists for a really good execution here, but not mentioning the intermittent fasting component was the only part designed to result in a caloric deficit is a bit of a hand wave, no?
New @Cell_Metabolism on benefit of intermittent fasting in overweight individuals with metabolic syndrome
A randomized trial showed that the Mediterranean diet, while reducing lipid abnormalities, did not suppress inflammation until intermittent fasting was added
cell.com/cell-metabolism/fulā¦
It is⦠not great that they are just becoming familiar with lab timelines.
Wait until they hear about clinical trial timelines.
Where do you go next after reporting from the Strait of Hormuz? For the past three months, Citrini Research, an independent research firm, has been working with our team and an internal research model to see if they could use AI to create a new drug. What follows is an entertaining, candid, and humbling account of a group of motivated nonexperts (or āfilthy casualsā, as Citrini would say) trying to tackle a real problem in human health with Claude.
We landed on scorpion neurotoxins, which kill over 3,000 people a year. Of the 211 designs we produced and tested, 17 met our criteria for a binder. None of the designs bound more than one toxin and none have been tested for neutralizing a toxin.
One of my favorite quotes from the piece is: āOur virtual biologist may have compressed a year's worth of work into a couple days, but biology works at the speed of lifeā¦Over two days, we watched Claude work through problems at a speed that was difficult to comprehend. For the next two months, we spent much of the time becoming familiar with laboratory turnaround times (This mostly involved sending memes in Slack).ā
I donāt know a lot of residents that only work 65 hours per week, either.
I'm not saying residents should be paid like attendings. I'm saying the math deserves to be said out loud.
$66,712 divided by roughly 3,380 hours a year is about $20 an hour, before taxes and before the student loans keep growing in the background.
If you're in training right now: your income will change. Your habits won't unless you decide they will.
What did your hourly rate work out to in residency?
In training? My free live lecture series starts in January. Save your spot with the link in my bio.
Setting aside āstudying actual medicine for a secondā ā letās not over-exacerbate how indicative of medical mastery differences even a started deviation level difference in grade or step1 score are.
We are talking about 1 or 2 questions per test on highly biased question structures from reams of PowerPoint slides chosen by lecturers with motives that vary wildly on question selections that result in focusing on memorizing esoteric slide details over topic mastery.
For step1 (which Iāve historically defended, and Iāll tell you my score if you care/think Iām biased), a 5 point difference is a couple of questions with unclear relevance to patient outcomesā is knowing lesch nyhan is an hprt1 mutation that impedes purine recycling or objectively challengable theoretical biochemistry questions (I took graduate biochemistry courses, suggesting single metabolites are definitely the right answer to hypothetical TCA manipulations is hilarious) predictive of clinical success? Further, is making most questions structured as frequentist statistical approaches over Bayesian ones in order to make the questions more arbitrary and therefore āharderā helping make anyone a better clinician? Especially if it results in answering in such a way that youād never be caught dead actually practicing on the clinic? Absolutely no chance.
I know no one will real this, but I disagree with almost all the commentary here.
Design med school to be mastery-based, increase the residency spots so the number of competitive seats grows, and let kids separate themselves on aggregate honest reviews, genuine clinical mastery, step1/2 scores on a more representative test, and substantive research output. Demand a more fair and less gameable framework, and the future doctors will rise to that level.
This account seems fun/cool but this is the absolute worst in grading behaviors and should be characterized as such.
Bringing guac or bagels or whatever should be actively denigrated in grading as a likely grade bribe⦠Iām sure the kid who did it was totally competent, but the idea that residency fates are being decided by who brings in snacks is categorically absurd
Iām sick of people who donāt know what they are talking about blasting out commentary about clinical medicine
Re: Jalen Hurts, hematology is an incredibly specialized area of medicine in which every case and patient is very different.
I would be very careful about staking any dynasty fantasy football decisions on things you read here, even from doctors.
NFL players are, in general, a high-risk group for blood clots (higher BMI, lots of impact, lots of flying), and several have successfully returned to play after having them.
Christian Barmore sacked Geno Smith yesterday, and Chris Olave is fantasy football's WR7 after having a pulmonary embolism last December.
I love Pelissero in every way, but this is ridiculous today. Between the āhow much does he love footballā and now the post-reporting mea culpa, this is journalism by tweet at its worst.
Just spoke to Jalen Hurtsā agent, Nicole Lynn, who clarified that while Hurts was up until early Sunday morning getting evaluated at a hospital, he was able to sleep upon rejoining the team and the Eagles set aside a room for him at the stadium. Videos from the stadium show Hurts coming onto the field just before kickoff and he felt rested enough to play.
There is so much public and non-public info on insane medical and medical-adjacent malpractice (not even including the brain stuff) by nfl medical staffs and coaching staffs⦠idk how they get a pass for it all.
I know itās tough because players advocate to play a lot, but my goodness.
Jalen Hurts timeline is just organizational malpractice:
- Finds out thereās a superficial blood clot while in London
- Team doctors instruct him not to sleep
- Jalen Hurts doesnāt sleep for 36 hours and then PLAYS in the London game
- Blood clot moved locations
- Jalen Hurts flies back to the US
- He gets placed on blood thinners. And is now out for the season.
Rare occasion where I genuinely hope someone is cosplaying as a doctor
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