“Can We Reverse Aging?” is our episode title. My answer: not yet with today’s science. Maybe someday. I joined @DarshanShah_MD to discuss slowing aging and extending healthy lifespan. I hope you’ll watch the full conversation. Thanks for your support! youtu.be/P5053hkoXU8

The Effect of Daily Low Dose Tadalafil on Cerebral Perfusion and Cognition in Patients with Erectile Dysfunction and Mild Cognitive Impairment “The results of this prospective clinical study suggest that daily use of tadalafil 5 mg increases some regional CBF and improves cognitive function in patients with ED and mild cognitive impairment.” pmc.ncbi.nlm.nih.gov/article…

Decoding Vascular Senescence: Cellular Insights and Therapeutic Strategies ijbs.com/v22p7686.htm

Sex-Specific Neurogenic and Cognitive Responses in a Murine Model of Accelerated Aging “ER272 was associated with improved cognitive performance and preservation of multiple neurogenic parameters in males but showed limited effects in females.” onlinelibrary.wiley.com/doi/…

Health Related Quality of Life and Personality Characteristics for Aging Well: Evidence from the Sardinian Blue Zone 💡"the combination of adaptive personality traits and coping resources promotes a more active lifestyle, providing insights into the mechanisms of successful aging." link.springer.com/article/10…

'Low-Oxygen' Drug Combination Reverses Parkinson's Symptoms in Mice sciencealert.com/low-oxygen-…

Microsoft’s Mustafa Suleyman says its AI outperforms doctors on hard cases as he chases ‘medical superintelligence’ techcrunch.com/2026/10/22/mi…

ADHD Drugs May Reduce The Risk of Early Death, Major Study Finds sciencealert.com/adhd-drugs-…

The FOXO-aging axis: Epigenetic insights and chromatin mechanisms “… Chromatin context-specific FOXO targeting may improve anti-aging therapy...” sciencedirect.com/science/ar…

Meningiomas are associated with some birth control Brain tumor risk linked to progestin-based shot is lower than other birth control risks, like blood clots and stroke. braintumorcenter.ucsf.edu/ne…

This chart shows just how rapidly Ebola is spreading No previous Ebola outbreak has grown this quickly. More @voxdotcom: vox.com/future-perfect/50707…

Just one small caveat: let’s not confuse what centenarians believe helped them live so long with what actually did. 🍻

Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep “… tightly synchronized oscillations in norepinephrine, cerebral blood volume, and cerebrospinal fluid (CSF) as the strongest predictors of glymphatic clearance during NREM sleep. ” cell.com/cell/fulltext/S0092…

How high ventilation breathwork alters consciousness: Hypoperfusion, network dynamics, and subjective experience 😵‍💫“High ventilation breathwork (HVB) is increasingly used in psychotherapeutic and contemplative contexts to induce altered states of consciousness (ASC)…” sciencedirect.com/science/ar…

Ubiquitous Sirt1 overexpression is associated with preserved cardiac diastolic function and mitochondrial respiratory capacity in mice on a high-fat diet sciencedirect.com/science/ar…

Ongoing lawsuits allege GLP-1s can cause serious harm. But we don't know how often nprillinois.org/2026-10-10/o…

From self-quantification to predictive ageing: Digital twins as a framework for healthy ageing and longevity 🗣️"A prominent example is the Blueprint project generated by Bryan Johnson (Johnson, 2024), which integrates repeated measurements across metabolic, cardiovascular, inflammatory, functional, imaging and epigenetic domains..."📊 👨‍⚕️Re: @bryan_johnson: "We propose a digital twin framework that models healthy ageing as a latent dynamical system rather than static biomarkers..." sciencedirect.com/science/ar…