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Perspective outlining multiple entry points for studying the molecular basis of human brain evolution with @TylerFair_ sciencedirect.com/science/ar…
Alex Pollen retweeted
1/ Most genes and variants matter somewhere but look silent in any one cell model. Can we build conditions that reveal phenotypes? With @kanishkadey, we engineer cell states to expose hidden disease biology and trace how genetic risk reaches disease genes. biorxiv.org/content/10.64898…
ALT Visual abstract: activating TFs singly and in pairs engineers new cell states, and the Mosaic model learns how TFs combine. Findings: hidden AMD risk variants, state-dependent convergence, and chromatin priming.
Alex Pollen retweeted
First preprint from the lab, led by @rantinggev!
We identify a metabolic bottleneck that helps set the pace of human development: low levels of the redox enzyme GPD1L limit NADH recycling. Boosting GPD1L mimics mouse cells and accelerates development!
biorxiv.org/content/10.64898…
Alex Pollen retweeted
Interested in single cell genomics but need help getting started? Come to my lab's 10th (!) Single Cell Genomics Day on 6/12
Talks include Aviv Regev @anshulkundaje @junyue_cao @xinjin + (many) more + @ATJCagan illustrations!
Free Youtube livestream at satijalab.org/scgd
Alex Pollen retweeted
Form follows function, or function dictates form?
📢Preprint: we build Perturb-CLEAR, in vivo screen of neuroanatomy! Disease perturbations produce selective morphology-RNA changes that RNA impact alone cannot predict. Was led by the invincible @BoliWu!
biorxiv.org/content/10.64898…
Alex Pollen retweeted
New preprint on Detectrons from @jihoon_han_phd! These are programmable biosensors for RNAs that produce DNA barcodes in the presence of their target RNA. Check out Jihoon's quoted thread for more:
biorxiv.org/content/10.64898…
Excited to share a preprint from my postdoc work in @seth_shipman’s lab!
We developed Detectrons — programmable biosensors that convert RNA signals into stable DNA barcodes inside living cells, enabling multiplexed RNA sensing. 🧵👇
biorxiv.org/content/10.64898…
Alex Pollen retweeted
NEXT TUE: DDD seminar, Feb. 17, 2026 @ 1PM Eastern US: Dr. Annerieke Sierksma (Dr. Bart De Strooper's @BStrooper group @ KU Leuven) present "Polygenic risk for Alzheimer’s disease shapes microglial inflammatory and antigen-presentation programs in vivo". carlocolantuoni.org/seminar
Alex Pollen retweeted
Today I'd like to honor the memory of my mentor and friend, Roger Tsien, born 1952 February 1. Today would have been Roger's 74th birthday.
Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.
Alex Pollen retweeted
Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element biorxiv.org/content/10.64898…
Alex Pollen retweeted
Excited to share work I contributed to during my UCSF postdoc with amazing colleagues, including Dr. Tianzhi Wu & Dr. Jingjing Li! @Kriegsteinlab @jingjingSF @UCSFstemcell ❤️
nature.com/articles/s41587-0…
1/ Our new study, led by @ding5066, examines the role of transcription factors during human neurogenesis to identify gene regulatory networks influencing cell fate, maturation, and subtype specification
nature.com/articles/s41586-0…
9/ We hope our study will provide a framework for functionally studying how disease and evolution shape human cortical development.
10/ Thanks to @lessi_manuel for highlighting a preprint of the study prelights.biologists.com/hig…
