AI × biology × capitalism (but make it fun) 🧬 | Likes: all things biology, nature, equality 🌱 | Comms & Brand @ProfluentBio | he/him
NYCish
Joined July 2009
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cas retweeted
The government is backing us for a moonshot to design *personalized curative* medicines. Excited to be partnering with GemmaBio and be in the elite company of the best medical centers in the world.
Each word has significance.
Personalized = bespoke to each patient [this is where programmable biology with AI can directly play a role]
Curative = lasting solutions that cure not just manage disease. This is what we at Profluent live for, real cures to disease.
Let's go build!
cas retweeted
first time agreeing to do a podcast b/c (1) @nathanbenaich is legend and (2) there's so much happening in the field [modeling paradigms, effect of scale, big deals, clinical readouts]
it's a builder's future, now.
it's been a huge few weeks for ai in bio: a $2.25b @profluentbio x @elilillyandco deal on ai-designed gene editors, verve's base-editing data, new scaling results on protein models from @czbiohub, @isomorphiclabs' haul.
@thisismadani and i recorded a pod diving into all of it
we get into taking biology from discovery to design, sequence-first vs structure-first, and why he calls this the "gpt-1.5 era" of biology...
enjoy!
cas retweeted
it's been a huge few weeks for ai in bio: a $2.25b @profluentbio x @elilillyandco deal on ai-designed gene editors, verve's base-editing data, new scaling results on protein models from @czbiohub, @isomorphiclabs' haul.
@thisismadani and i recorded a pod diving into all of it
we get into taking biology from discovery to design, sequence-first vs structure-first, and why he calls this the "gpt-1.5 era" of biology...
enjoy!
cas retweeted
I was going to get off my biosecurity refusal hobby horse today but my brilliant product thinking has again been thwarted by Claude. What can we do about this @AnthropicAI ???
just riffing on taglines, don’t mind me
- Are You Wet Yet?
- Wet Enough For You.
- Wet and Wild 🦬
cc @thisischristina @p_maverick_b
Today we’re launching American Wetware, a design studio for building with biology 🇺🇸💧
I’m doing this together with @thisischristina and @p_maverick_b
Our mission is to learn the design language of biology
when my wife asks what I’m watching while I scroll the internet, I’ve started describing everything as “oh, it’s an art project…”
it’s making me appreciate the memes more
cas retweeted
What a time to be alive americanwetware.com/gel_inva…
dolphins in the East River should get the Punxsutawney Phil treatment: live coverage, a handler in a top hat, and a climate prediction
and any whale in NY Harbor should close the schools. @NYCMayor
If I lived in SF, I would jump at this Dir. of Marketing & Brand job. Sounds so cool.
Immediately had visions of what the brand could be 🌊🐚🪸
I’m hiring for two major roles on my team at Ulysses.
There has not been a better time to join Ulysses.
In the last few months, revenue & pipeline have gone vertical, and we've made significant technological breakthroughs that will forever change how subsea work is done.
It's been the most successful period in our company's history, and we are just getting started.
We will be announcing some of these breakthroughs soon. Stay tuned.
The jobs:
1. GM, Commercial: Your job is to stand up and lead our commercial business unit. Take our early contracts and scale them to build a machine that reshapes how critical telecoms and energy infrastructure is inspected and repaired.
2. Director of Marketing and Brand. Your job is to make Ulysses impossible to ignore. World-build. Make Ulysses "the Ocean Company". Take the air out of the room. High taste. No slop. Tell the world what Ulysses does.
Quit your boring desk job.
The ocean is calling.
Full job descriptions are @ ulysses.inc/jobs
Wild stuff
After reading this, I’m more convinced than ever that artificial wombs are a matter of when not if. And suspect it’ll go badly!
Rich tech types would gladly engineer away human unpredictability in an attempt to control biology
When her son died in utero, a venture capitalist went to extremes to punish her surrogate. wired.com/story/the-baby-die…
everyday, I wake up, open the window, take a deep breath, and yell out:
‘protein binder generation models dont actually matter all that much, bc optimizing binding is one of the easiest and least costly steps in the drug design process’
it has become in vogue to say ‘protein binder generation models dont actually matter all that much, bc optimizing binding is one of the easiest and least costly steps in the drug design process’
but the argument against that (which i increasingly believe!) is that drug development is bottlenecked not necessarily by money — money is actually very abundant — but rather by the total ‘surface area’ of drug development that big pharma perceives is promising enough to help push along. this is correlated with money! but it is not money. it is actually attention
binders-on-demand may dramatically increase that surface area — via the instant transmutation of uncertain biology into experimentally tractable biology — in weird ways that are very hard to foresee
…Sesame Street is Sesame Street for the 2020s…
learning how to be a decent human being who cares for and respects others is everything you need to know to do awesome in life
using AI for big things over here
(Big TP is hiding the truth from us. My TP holder can't fit those mega rolls!!)
