@choyle22

Postdoc at the University of Manchester researching inflammasomes

 Manchester, England
Joined November 2011
  • Tweets184
  • Following246
  • Followers282
16Media
New MRC DTP PhD project is available with David Brough, Kevin Couper, Roy Ng and myself looking at the NLRP3 inflammasome in the brain and brain disease findaphd.com/phds/project/mr…. Please get in touch with Prof Brough to discuss if you are interested! @BIG_research

(MRC DTP) Targeting inflammasomes to reduce inflammatory damage in brain disease at The University...

PhD Project - (MRC DTP) Targeting inflammasomes to reduce inflammatory damage in brain disease at The University of Manchester, listed on FindAPhD.com

findaphd.com
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Have you submitted your abstract yet? Don't miss out on this great meeting! Fantastic line up (really!!) and great occasion for ECR to present their research for talks and poster!
BSI Congress & Events@bsicongress26 Jun 2025
🔥 Dive into the latest on inflammasomes, innate immunity & more at our event with @BSI_Inflam on 11–12 Sept in Manchester! Cutting-edge talks, career workshops & networking with experts. Abstract deadline: 15 July! ☑️ Submit your abstract & register: bit.ly/43q9x9r
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Chris Hoyle retweeted
Sarah Ryan@DrSarahRyan9 Sep 2024
NEW PAPER ALERT! 🚨 And it dropped on my bday, so thanks @braincomms! C9orf72 dipeptides activate the NLRP3 inflammasome 👇🏻👇🏻👇🏻 Huge thanks to @choyle22, @mere_conjecture, @ComorbidCath & the rest of the team not on X, plus @AlzSocResearch for funding. academic.oup.com/braincomms/…

C9orf72 dipeptides activate the NLRP3 inflammasome

A C9orf72 repeat expansion causes frontotemporal dementia and amyotrophic lateral sclerosis. The expansion is translated to produce dipeptides that activat

academic.oup.com
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Our new paper exploring the nuclear role of pro-IL-1α is out now in Nature Comms! nature.com/articles/s41467-0… A first for myself as a first author and @choyle22 as corresponding author… go team!! 💪🏻 Such valuable work and support from all the other wonderful people involved ✨

Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions

Nature Communications - Interleukin (IL)-1α is a critical inflammatory cytokine and yet its intracellular role is poorly understood. Here, the authors use proximity labelling of pro-IL-1α...

nature.com
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NEW PAPER: nature.com/articles/s41467-0… Summary: We delve into the nuclear role of pro-IL-1α, using proximity labelling to identify several proteins that may interact with pro-IL-1α in the nucleus, including HATs, and find many species that have lost IL-1α nuclear localisation

Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions

Nature Communications - Interleukin (IL)-1α is a critical inflammatory cytokine and yet its intracellular role is poorly understood. Here, the authors use proximity labelling of pro-IL-1α...

nature.com
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We hypothesise that HAT binding may be the primary intracellular role of pro-IL-1α, and the NLS may serve an auxiliary role – either to facilitate binding to HATs in the nucleus, or instead it may be related to IL-1α trafficking and release
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Big thanks to @Rose_Wellens for all of her work, and also to the rest of the team!
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Our paper is now out in @CellReports! Please give it a read, particularly those interested in #microglia, #macrophages, and #stroke. We show the MNP response to stroke is all about where you're from (ontogeny), where you're at (space), and where youre heading (substates).
Cell Reports@CellReports20 May 2024
Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity dlvr.it/T77dZw

Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell...

Patir et al. show the identities of resident microglia and immigrant macrophages responding to stroke in brain areas near and remote to damage. Each niche is occupied by discrete ontogeny-phenotype...

cell.com
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Chris Hoyle retweeted
Emily McMahon@EmzMcM12 Feb 2024
My first ever research paper is out !! 👩🏼‍🔬🎉 👉👉pubmed.ncbi.nlm.nih.gov/3832… A natural product "brazilin" inhibits the NLRP3 inflammasome pathway, a key driver of numerous inflammatory human diseases including those affecting the brain such as stroke and dementia. – at Manchester, England
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Chris Hoyle retweeted
RoyNgLab@RoyNgLab30 Oct 2023
An exciting PhD opportunity to join my lab studying NLRP3 inflammasome in vascular dementia. This project is in collaboration with @KasherLab Prof. David Brough, and Dr. Ingo Schiessl. Please contact me for details ([email protected]) findaphd.com/phds/project/mr…

(MRC DTP) Study of the crosstalk between adiponectin and NLRP3-inflammasome pathways in vascular...

PhD Project - (MRC DTP) Study of the crosstalk between adiponectin and NLRP3-inflammasome pathways in vascular dementia at The University of Manchester, listed on FindAPhD.com

findaphd.com
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⚠️ New #NF2 research paper out! I am elated! Are #NF2SWN #vestibularschwannoma similar or different to sporadic tumours? Read the paper or the video abstract to find out! academic.oup.com/braincomms/… Thanks to our fab authors and funders @nf2biosolution1 @NF2BioSolutions @DNS_UOM
Omar Pathmanaban@brain_op23 Jul 2023
NF2-related schwannoma & sporadic vestibular schwannoma: same tumour or different? See our recent paper to find out! ⁦@GJBrainResearch⁩ ⁦@SNOMAN_Lab⁩ ⁦@MCCN_UK⁩ ⁦@LydiaBeckerIII⁩ ⁦@NCAresearchNHS⁩ ⁦@MCRskullbase⁩ academic.oup.com/braincomms/…

The comparable tumour microenvironment in sporadic and NF2-related schwannomatosis vestibular...

Vestibular schwannoma are brain tumours found in NF2-related schwannomatosis patients and non-NF2-related schwannomatosis sporadic patients. Gregory et al.

academic.oup.com
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Happy to share that our paper on the discovery of compounds that inhibit the AIM2 inflammasome is now published 🥳 – Check it out here cell.com/iscience/fulltext/S…
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Studying various cell lines, researchers probe the inflammasome #NLRP3 and show how disruptions to #endosomal trafficking can sensitize macrophages to NLRP3 activators, enhancing inflammasome activation and cytokine secretion. @FBMH_UoM scim.ag/1En
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Happy that our latest paper on NLRP3 activation is out, great work by @BaliCLee @wellens_rose and everyone else!! science.org/doi/10.1126/scis…

Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome

The NLRP3 inflammasome senses and is activated by perturbations in endosomal trafficking.

science.org
Rose Wellens@Rose_Wellens22 Feb 2023
Beyond thrilled to have our research published in @scisignal AND to get the front cover 🤯🔬 The teamwork that went into this paper is something that we’re all very proud of🧪@choyle22 @drjackpgreen @UoM_GEU @BillieJMatchett @Glo_loca
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Beyond thrilled to have our research published in @scisignal AND to get the front cover 🤯🔬 The teamwork that went into this paper is something that we’re all very proud of🧪@choyle22 @drjackpgreen @UoM_GEU @BillieJMatchett @Glo_loca
Science Signaling@scisignal21 Feb 2023
A study ties an inflammatory protein complex’s activity to “traffic jams” in cell cargo transport, research in cells reveals how a kinase helps insulin regulate cell metabolism, and more in this week’s new issue of #ScienceSignaling. scim.ag/1DM
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🚨Excellence in Diversity PhD Scholarships - deadline 31st January🚨 Please encourage potential candidates from under-represented groups* to apply for fully funded PhD positions at UoM - especially if they want to be a part of our BIG research team 🧠🧪 bmh.manchester.ac.uk/study/r…*
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